全文获取类型
收费全文 | 780篇 |
免费 | 104篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 15篇 |
妇产科学 | 7篇 |
基础医学 | 100篇 |
口腔科学 | 4篇 |
临床医学 | 101篇 |
内科学 | 207篇 |
皮肤病学 | 9篇 |
神经病学 | 72篇 |
特种医学 | 17篇 |
外科学 | 99篇 |
综合类 | 3篇 |
一般理论 | 1篇 |
预防医学 | 84篇 |
眼科学 | 7篇 |
药学 | 17篇 |
中国医学 | 3篇 |
肿瘤学 | 131篇 |
出版年
2024年 | 1篇 |
2023年 | 4篇 |
2022年 | 19篇 |
2021年 | 40篇 |
2020年 | 26篇 |
2019年 | 40篇 |
2018年 | 52篇 |
2017年 | 28篇 |
2016年 | 37篇 |
2015年 | 42篇 |
2014年 | 37篇 |
2013年 | 38篇 |
2012年 | 62篇 |
2011年 | 51篇 |
2010年 | 36篇 |
2009年 | 28篇 |
2008年 | 25篇 |
2007年 | 31篇 |
2006年 | 29篇 |
2005年 | 40篇 |
2004年 | 27篇 |
2003年 | 23篇 |
2002年 | 23篇 |
2001年 | 12篇 |
2000年 | 17篇 |
1999年 | 7篇 |
1998年 | 9篇 |
1997年 | 8篇 |
1996年 | 7篇 |
1995年 | 4篇 |
1994年 | 8篇 |
1993年 | 6篇 |
1992年 | 14篇 |
1991年 | 10篇 |
1990年 | 12篇 |
1989年 | 5篇 |
1988年 | 6篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1983年 | 1篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有885条查询结果,搜索用时 640 毫秒
21.
Baptiste Sandoz Alina Badina Sébastien Laporte Karene Lambot David Mitton Wafa Skalli 《Medical & biological engineering & computing》2013,51(9):971-979
Better understanding of the effects of growth on children’s bones and cartilage is necessary for clinical and biomechanical purposes. The aim of this study is to define the 3D geometry of children’s rib cages: including sternum, ribs and costal cartilage. Three-dimensional reconstructions of 960 ribs, 518 costal cartilages and 113 sternebrae were performed on thoracic CT scans of 48 children, aged 4 months to 15 years. The geometry of the sternum was detailed and nine parameters were used to describe the ribs and rib cages. A “costal index” was defined as the ratio between cartilage length and whole rib length to evaluate the cartilage ratio for each rib level. For all children, the costal index decreased from rib level 1 to 3 and increased from level 3 to 7. For all levels, the cartilage accounted for 45–60 % of the rib length, and was longer for the first years of life. The mean costal index decreased by 21 % for subjects over 3-year old compared to those under three (p < 10?4). The volume of the sternebrae was found to be highly age dependent. Such data could be useful to define the standard geometry of the pediatric thorax and help to detect clinical abnormalities. 相似文献
22.
Maxence Serru Bénédicte Marechal Tobias Kober Leo Ribier Catherine Sembely Taveau Dominique Sirinelli Jean-Philippe Cottier Baptiste Morel 《Journal of neuroradiology. Journal de neuroradiologie》2021,48(4):259-265
Background and purposeIt can be challenging to depict brain volume abnormalities in the pediatric population on magnetic resonance imaging (MRI). The aim of the study was to evaluate the inter-radiologist reliability in brain MRI interpretation, including brain volume assessment and the efficiency of an automated brain segmentation.Materials and methodsWe performed a single-center prospective study including 44 patients aged six months to five years recruited from the University Hospital, having a 1.5 T brain MRI using a MP2RAGE sequence. All MRI were randomly and blindly reviewed by one junior and two senior pediatric radiologists. Inter-observer agreements were assessed using Fleiss’ kappa coefficient. Brain volumetry (total intracranial volume (TIV), brain parenchyma, and cerebrospinal fluid volumes) was estimated using the MorphoBox prototype. Clinical head circumference (HC) and z scores were reported. A Pearson correlation coefficient was calculated between brain volumes with HC.ResultsTwenty-four brain MRI examinations were normal and twenty were pathological. Brain volume abnormalities were poorly detected by junior and senior radiologists: sensitivities 16.67% [confidence interval 4.7–44.8], 33.33% [13–60] and 30.7% [12–58] and specificities 93.75% [79–98], 84.38% [68–93] and 77% [60–88], respectively. Brain volume apart, interobserver kappa coefficients were 0.93 between junior and seniors as well as between seniors. Brain volumes were significantly correlated with HC (P < 0.0001). In patients with normal MRI, brain parenchyma volumes increased regularly with age. Low brain volume was easier to identify with automated quantification.ConclusionBrain volume was poorly appreciated by radiologists. The fully automated brain segmentation used can provide quantitative data to better diagnose, describe, and follow-up brain volume abnormalities. 相似文献
23.
24.
25.
Jorian Prudhomme Céline Toty Ozge Erisoz Kasap Nil Rahola Baptiste Vergnes Carla Maia Lenea Campino Maria Antoniou Maribel Jimenez Ricardo Molina Arnaud Cannet Bulent Alten Denis Sereno Anne-Laure Bañuls 《Acta tropica》2015
The population structure of Phlebotomus ariasi, a proven vector of Leishmania infantum in the Mediterranean area, is still poorly understood. Previously, only two microsatellite loci had been developed to study the population genetics of this species. Herein we use these loci and determined fourteen novel microsatellite loci, useful for the characterization of P. ariasi populations. These loci were tested on three populations of P. ariasi, two from France and one from Portugal. In addition, the usefulness of these markers was also evaluated on seven other sandfly species. 相似文献
26.
27.
28.
Nagalo BM Bisseye C Sanou M Kienou K Nebié YK Kiba A Dahourou H Ouattara S Nikiema JB Moret R Zongo JD Simpore J 《Tropical medicine & international health : TM & IH》2012,17(2):247-253
Background and objective The high prevalence of numerous transfusion‐transmitted infectious diseases such as HIV, HBV, HCV and syphilis in sub‐Saharan Africa affects blood safety for transfusion recipients. The aim of this study was to evaluate the prevalence and incidence of transfusion‐transmissible infectious diseases among blood donors in Burkina Faso. Methods A retrospective study of blood donors’ records from January to December 2009 was conducted. Prevalence and incidence of viral infections were calculated among repeat and first‐time blood donors. Results Of the total of 31 405 first‐time volunteer blood donors in 2009, 24.0% were infected with at least one pathogen and 1.8% had serological evidence of multiple infections. The seroprevalence of HIV, HBV, HCV and syphilis in first‐time volunteer donors was 1.8%, 13.4%, 6.3% and 2.1%, respectively. In 3981 repeat donors, the incidence rate was 3270.2, 5874.1 and 6784.6 per 100 000 donations for anti‐HIV‐1, HBsAg and anti‐HCV, respectively. These numbers varied significantly according to populations where blood is collected and blood centres in Burkina Faso. Conclusion The relatively high prevalence of viral markers in first‐time volunteers and remarkably high incidence of infections in repeat donors raise concerns regarding the safety of these donors and suggest that implementation of NAT might significantly improve the situation. 相似文献
29.
Andrew J Burghardt Jean‐Baptiste Pialat Galateia J Kazakia Stephanie Boutroy Klaus Engelke Janina M Patsch Alexander Valentinitsch Danmei Liu Eva Szabo Cesar E Bogado Maria Belen Zanchetta Heather A McKay Elizabeth Shane Steven K Boyd Mary L Bouxsein Roland Chapurlat Sundeep Khosla Sharmila Majumdar 《Journal of bone and mineral research》2013,28(3):524-536
High‐resolution peripheral quantitative computed tomography (HR‐pQCT) has recently been introduced as a clinical research tool for in vivo assessment of bone quality. The utility of this technology to address important skeletal health questions requires translation to standardized multicenter data pools. Our goal was to evaluate the feasibility of pooling data in multicenter HR‐pQCT imaging trials. Reproducibility imaging experiments were performed using structure and composition‐realistic phantoms constructed from cadaveric radii. Single‐center precision was determined by repeat scanning over short‐term (<72 hours), intermediate‐term (3–5 months), and long‐term intervals (28 months). Multicenter precision was determined by imaging the phantoms at nine different HR‐pQCT centers. Least significant change (LSC) and root mean squared coefficient of variation (RMSCV) for each interval and across centers was calculated for bone density, geometry, microstructure, and biomechanical parameters. Single‐center short‐term RMSCVs were <1% for all parameters except cortical thickness (Ct.Th) (1.1%), spatial variability in cortical thickness (Ct.Th.SD) (2.6%), standard deviation of trabecular separation (Tb.Sp.SD) (1.8%), and porosity measures (6% to 8%). Intermediate‐term RMSCVs were generally not statistically different from short‐term values. Long‐term variability was significantly greater for all density measures (0.7% to 2.0%; p < 0.05 versus short‐term) and several structure measures: cortical thickness (Ct.Th) (3.4%; p < 0.01 versus short‐term), cortical porosity (Ct.Po) (15.4%; p < 0.01 versus short‐term), and trabecular thickness (Tb.Th) (2.2%; p < 0.01 versus short‐term). Multicenter RMSCVs were also significantly higher than short‐term values: 2% to 4% for density and micro–finite element analysis (µFE) measures (p < 0.0001), 2.6% to 5.3% for morphometric measures (p < 0.001), whereas Ct.Po was 16.2% (p < 0.001). In the absence of subject motion, multicenter precision errors for HR‐pQCT parameters were generally less than 5%. Phantom‐based multicenter precision was comparable to previously reported in in vivo single‐center precision errors, although this was approximately two to five times worse than ex vivo short‐term precision. The data generated from this study will contribute to the future design and validation of standardized procedures that are broadly translatable to multicenter study designs. © 2013 American Society for Bone and Mineral Research. 相似文献
30.
Adrian S. Fairey Wassim Kassouf Eric Estey Simon Tanguay Ricardo Rendon David Bell Jonathan Izawa Joseph Chin Anil Kapoor Edward Matsumoto Peter Black Alan So Jean‐Baptiste Lattouf Fred Saad Darrel Drachenberg Ilias Cagiannos Louis Lacombe Yves Fradet Niels‐Erik B. Jacobsen 《BJU international》2013,112(6):791-797