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651.
Marcy Pierre Yves Barbut Jonathan Bertrand Anne Sophie Lacout Alexis Morvan Jean Baptiste 《World journal of surgery》2020,44(4):1332-1333
World Journal of Surgery - 相似文献
652.
Peripheral nerve stimulation characteristics of an asymmetric head‐only gradient coil compatible with a high‐channel‐count receiver array 下载免费PDF全文
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Esther Ebstein Baptiste Coustet Vanina Masson-Behar Marine Forien Elisabeth Palazzo Philippe Dieudé Sébastien Ottaviani 《Joint, bone, spine : revue du rhumatisme》2018,85(5):577-581
Objective
We aimed to compare the prevalence of enthesopathy seen on ultrasonography (US) in spondyloarthritis (SpA) and rheumatoid arthritis (RA) and compared it to healthy controls.Methods
All included patients with RA (2010 ACR/EULAR criteria) and SpA (ASAS criteria) and healthy controls underwent clinical and US evaluation of enthesis at seven sites (quadriceps, proximal and distal patellar, Achilles and triceps tendons, plantar aponeurosis and lateral epicondyle enthesis). The Glasgow Ultrasound Enthesitis Scoring System (GUESS) and the Madrid Sonographic Enthesitis Index (MASEI) scores were determined by two sonographers blinded to clinical data.Results
We included 30 patients with RA (mean age: 55.7 ± 14.8 years, mean disease duration 10.5 ± 7.9 years); 41 with SpA (mean age: 45.3 ± 15.4 years, mean disease duration 9.2 ± 8.7 years) and 26 healthy controls (HC) (mean age: 50.4 ± 17.3 years). Patients with SpA and RA had similar prevalence of painful enthesis of examined sites (17% vs. 14%, non-significant [ns]), but more than among in healthy controls (3%, P < 0.05 for RA and SpA comparison). Comparison between SpA and RA patients revealed that at least one US enthesis abnormality was found with similar frequency (46% and 48% sites [ns]) but both rheumatic diseases had higher frequency of US enthesis abnormality than HC (31%, P < 0.05 for RA and SpA comparison). The mean MASEI score was 8.5 ± 7.3 for RA patients, 7.8 ± 6.5 for SpA patients (ns) and 3.4 ± 2.8 for healthy controls (P < 0.05 for RA and SpA comparison). Overall, 6 RA (20%) and 4 SpA (10%) patients had a MASEI score ≥ 18 (ns). None of the healthy controls had a MASEI score ≥ 18 (P < 0.05 for RA and SpA comparison). The mean GUESS score was 5.8 ± 3.1 and 6.3 ± 3.9 for RA and SpA patients (ns), and 4.0 ± 3.1 for healthy controls (P < 0.01 vs. SpA and < 0.05 vs. RA).Conclusions
RA and SpA patients did not differ in entheseal abnormalities seen on US. Such US features may have low specificity in inflammatory conditions affecting joints and enthesis such as SpA and RA. 相似文献654.
Impact on patient management of the implementation of a magnetic resonance imaging dedicated to neurological emergencies 下载免费PDF全文
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Bala Y Depalle B Farlay D Douillard T Meille S Follet H Chapurlat R Chevalier J Boivin G 《Journal of bone and mineral research》2012,27(4):825-834
In the treatment of postmenopausal osteoporosis (PMOP), the use of alendronate (ALN) leads to a decrease in the risk of vertebral and nonvertebral fractures. To explore the possible adverse effects of prolonged ALN therapy, we studied the effects of 8 ± 2 years (6–10 years) of ALN treatment on the iliac cortical bone mineral and collagen quality and micromechanical properties; by design, our study examined these parameters, independent of the degree of mineralization. From six ALN‐treated and five age‐matched untreated PMOP women, 153 bone structural units have been chosen according their degree of mineralization to obtain the same distribution in each group. In those bone structural units, Fourier transform infrared spectroscopy, quantitative microradiography, and nanoindentation were used to assess bone quality. Irrespective of the degree of mineralization, ALN treatment was associated with higher collagen maturity (+7%, p < 0.001, c.v. = 13% and 16% in treated and untreated women, respectively) and lower mineral crystallinity than that observed in the untreated PMOP group (?2%, p < 0.0001, c.v. = 3% in both groups). Bone matrix from ALN‐treated women also had lower elastic modulus (?12%, p < 0.0001, c.v. = 14% in both groups) and, contact hardness (?6%, p < 0.05, c.v. = 14% in both groups) than that of untreated women. Crystallinity (which reflects the size and perfection of crystals) was associated with both elastic modulus and contact hardness in treated women exclusively (r = 0.43 and r = 0.54, p < 0.0001, respectively), even after adjustment for the amount of mineral. We infer that long‐term ALN treatment compromises micromechanical properties of the bone matrix as assessed ex vivo. The strength deficits are in part related to difference in crystallinity, irrespective of the mineral amount and mineral maturity. These novel findings at local levels of bone structure will have to be taken into account in the study of the pathophysiology of bone fragilities associated with prolonged ALN treatment. © 2012 American Society for Bone and Mineral Research. 相似文献
658.
Rigid spine syndrome associated with sensory‐motor axonal neuropathy resembling Charcot–Marie‐Tooth disease is characteristic of Bcl‐2‐associated athanogene‐3 gene mutations even without cardiac involvement 下载免费PDF全文
Jean‐Baptiste Noury MD Thierry Maisonobe MD Pascale Richard MD Valérie Delague MD Edoardo Malfatti MD PhD Tanya Stojkovic MD 《Muscle & nerve》2018,57(2):330-334
Introduction: Bcl‐2‐associated athanogene‐3 (BAG3) mutations have been described in rare cases of rapidly progressive myofibrillar myopathies. Symptoms begin in the first decade with axial involvement and contractures and are associated with cardiac and respiratory impairment in the second decade. Axonal neuropathy has been documented but usually not as a key clinical feature. Methods: We report a 24‐year‐old woman with severe rigid spine syndrome and sensory‐motor neuropathy resembling Charcot–Marie–Tooth disease (CMT). Results: Muscle MRI showed severe fat infiltration without any specific pattern. Deltoid muscle biopsy showed neurogenic changes and discrete myofibrillar abnormalities. Electrocardiogram and transthoracic echocardiography results were normal. Genetic analysis of a panel of 45 CMT genes showed no mutation. BAG3 gene screening identified the previously reported c.626C>T, pPro209Leu, mutation. Discussion: This case indicates that rigid spine syndrome and sensory‐motor axonal neuropathy are key clinical features of BAG3 mutations that should be considered even without cardiac involvement. Muscle Nerve, 57 : 330–334, 2018 相似文献
659.
Baptiste Demey Vronique Descamps Claire Presne Francois Helle Catherine Francois Gilles Duverlie Sandrine Castelain Etienne Brochot 《Viruses》2021,13(2)
Background: Kidney transplant recipients (KTRs) are exposed to a high risk of BK polyomavirus (BKPyV) replication, which in turn may lead to graft loss. Although the microRNAs (miRNAs) bkv-miR-B1-3p and bkv-miR-B1-5p are produced during the viral cycle, their putative value as markers of viral replication has yet to be established. In KTRs, the clinical relevance of the changes over time in BKPyV miRNA levels has not been determined. Methods: In a retrospective study, we analyzed 186 urine samples and 120 plasma samples collected from 67 KTRs during the first year post-transplantation. Using a reproducible, standardized, quantitative RT-PCR assay, we measured the levels of bkv-miR-B1-3p and bkv-miR-B1-5p (relative to the BKPyV DNA load). Results: Detection of the two miRNAs had low diagnostic value for identifying patients with DNAemia or for predicting DNAuria during follow-up. Seven of the 14 KTRs with a sustained BKPyV infection within the first year post-transplantation showed a progressive reduction in the DNA load and then a rapid disappearance of the miRNAs. DNA and miRNA loads were stable in the other seven KTRs. Conclusions: After the DNA-based diagnosis of BKPyV infection in KTRs, bkv-miR-B1-3p and bkv-miR-B1-5p levels in the urine might be valuable markers for viral replication monitoring and thus might help physicians to avoid an excessive reduction in the immunosuppressive regimen. 相似文献
660.
Jean‐Baptiste Bossard Jean‐Baptiste Beuscart Marie Robin Mohamad Mohty Fiorenza Barraco Patrice Chevallier Tony Marchand Marie‐Thrse Rubio Amandine Charbonnier Didier Blaise Jacques‐Olivier Bay Carmen Botella‐Garcia Gandhi Damaj Florence Beckerich Patrice Ceballos Thomas Cluzeau Jrme Cornillon Mathieu Meunier Corentin Orvain Alain Duhamel Federico Garnier Jean‐Jacques Kiladjian Ibrahim Yakoub‐Agha 《American journal of hematology》2021,96(1):80-88
The value of pretransplant splenectomy in patients with myelofibrosis (MF) is subject to debate, since the procedure may preclude subsequent allogeneic hematopoietic cell transplantation (allo‐HCT). To determine the impact of pretransplant splenectomy on the incidence of allo‐HCT, we conducted a comprehensive retrospective study of all patients with MF for whom an unrelated donor search had been initiated via the French bone marrow transplantation registry (RFGM) between 1 January 2008 and 1 January 2017. Additional data were collected from the patients' medical files and a database held by the French‐Language Society for Bone Marrow Transplantation and Cell Therapy (SFGM‐TC). We used a multistate model with four states (“RFGM registration”; “splenectomy”; “death before allo‐HCT”, and “allo‐HCT”) to evaluate the association between splenectomy and the incidence of allo‐HCT. The study included 530 patients from 57 centers. With a median follow‐up time of 6 years, we observed 81 splenectomies, 99 deaths before allo‐HCT (90 without splenectomy and nine after), and 333 allo‐HCTs (268 without splenectomy and 65 after). In a bivariable analysis, the hazard ratio [95% confidence interval (CI)] for the association of splenectomy with allo‐HCT was 7.2 [5.1‐10.3] in the first 4 months and 1.18 [0.69‐2.03] thereafter. The hazard ratio [95% CI] for death associated with splenectomy was 1.58 [0.79‐3.14]. These reassuring results suggest that splenectomy does not preclude allo‐HCT in patients with MF. 相似文献