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排序方式: 共有1576条查询结果,搜索用时 218 毫秒
91.
Ramadoss Sivakumar Puliyangudi Balakrishnan Sivaraman Narayanasami Mohan-Babu Ibrahim Mohamed Jainul-Abideen Perumal Kalliyappan Karundevi Balasubramanian 《Toxicological sciences》2006,91(2):550-556
Therapeutic, accidental, and experimental radiation exposures decreased serum testosterone in males, leading to various sexual problems. Since testicular Leydig cells are the predominant source of circulating testosterone, findings on the direct effects of radiation on Leydig cell steroidogenesis and the mechanism behind such effects would be of greater importance to the use of safer radiation doses in cancer therapy and to adopt preventive or therapeutic measures to alleviate postirradiation lesions, respectively. Therefore, this study was undertaken to explore the same using cultured human Leydig cells. Testicles removed from advanced prostatic carcinoma patients were used for isolation and purification of Leydig cells. Purified Leydig cells were cultured and then exposed to different doses (2, 4, 6, 8, and 10 Gy) of fractioned gamma radiation. Normal and irradiated cells were used for luteinizing hormone (LH) receptor quantification or total RNA isolation to study LH receptor mRNA expression or LH/cyclic AMP (cAMP) stimulation test. While LH-stimulated cells were used for cAMP assay, LH- and cAMP-stimulated cells were used for the estimation of steroidogenic enzymes, testosterone and estradiol production. Radiation exposure caused adverse effects on Leydig cell steroidogenesis in a dose-dependent manner. While lower doses (2 and 4 Gy) were ineffective, higher doses (6 Gy and above) drastically decreased LH receptor, basal and LH-stimulated cAMP generation, and basal, LH-, and cAMP-stimulated steroidogenesis. While 2 Gy of radiation exposure increased the LH receptor mRNA level, other doses did not induce any significant change. Therefore, it is concluded that higher doses of radiation impair Leydig cell steroidogenesis by affecting LH signal transduction at the level of both pre- and post-cAMP generation. Decreased level of LH receptors following higher doses of radiation exposure is not coupled with impaired expression of its mRNA. 相似文献
92.
D. R. Nayak R. Balakrishnan Gopal Ashish Laxmi Rao 《Indian journal of otolaryngology and head and neck surgery》2002,54(3):232-233
A case of Primary extraraniul meningioma of the parapharyngcal space arising simulitueouly as two distinct tumour masses from
two sepurae cranial nerves is reported. The paucity of reported eases is the evidence for its rarily. 相似文献
93.
Sule A Gohar S Mittal G Balakrishnan C Mangat G Joshi VR 《The Journal of the Association of Physicians of India》2000,48(4):437-438
The case of a 40 year old female patient of SLE who developed fatal neuroleptic malignant syndrome following administration of serenase (haloperidol) is reported. Relevant literature has been reviewed. 相似文献
94.
Richard David Jones Robin Reid G. Balakrishnan Ann Barrett 《Pediatric blood & cancer》1993,21(2):111-116
We report 3 cases of multifocal synchronous osteosarcoma constituting 1% of osteosarcoma cases in the Scottish Bone Tumour Registry over 30 years. All were children and had a median age of 10 years. They all presented with multiple bony lesions in the absence of demonstrable pulmonary metastases. Treatment was with palliative radiotherapy in two and combination chemotherapy and radiotherapy in the most recent case. Survival was poor in all cases, with a median of 7 months. A proposal is made for genetic studies in future cases to help elucidate the origin of these tumours. The multicentric and metastatic hypotheses are discussed. © 1993 Wiley-Liss, Inc. 相似文献
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Suryanarayana KV Balakrishnan R Rao L Rahim TA 《International journal of pediatric otorhinolaryngology》1999,50(1):69-72
A case of extra osseous mesenchymal chondrosarcoma occuring in the parapharyngeal space in a 7-year-old girl, is being presented for its rarity. It is a slow growing, locally aggressive tumour with a high incidence of local recurrence as well as distant metastasis. It is rare in the pediatric age group and rarer in the parapharyngeal space. It has a poor prognosis, the 5-year survival rate varies between 30 and 50%. Radical surgery is the treatment of choice. Radiotherapy and chemotherapy have an adjuvant role. More experience with this tumour is required to evaluate the most effective treatment. Current literature on this subject has been reviewed. 相似文献
100.