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排序方式: 共有1306条查询结果,搜索用时 15 毫秒
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S. Hossein Fatemi Amelia Merz George R. Realmuto 《Journal of developmental and physical disabilities》2003,15(1):1-22
This review describes involvement of serotonin, Reelin, and Bcl2 in cerebellar pathology in autism. The literature regarding neurochemical, neuropathologic, and imaging aspects of autistic pathology as related to cerebellum is discussed. Where appropriate, relevant animal data are also presented to explain the impact of environmental and genetic influences on development of autism. 相似文献
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Gerald F. Williams RN RM Crit Care Cert BAppSc Grad Cert PSM MHA CN FRCNA Director of Nursing Services Fay J. Hatch RN RM RMHN Crit Care Cert BN Clinical Nurse Consultant Michael C. Bradley RN RMDN Crit Care Cert BN Registered Nurse 《Australian critical care》1997,10(4):113-118
Methanol intoxication, a rare and potentially lethal form of poisoning, usually results from ingestion and occasionally inhalation of methanol. Initial symptoms of blurred vision, elongated anion gap and metabolic acidosis are typically delayed and may not at first be recognised as methanol-related complaints. Once diagnosed, treatment must be prompt and definitive. As well as general supportive care, ethanol infusion, dialysis and alkalinization form the mainstays of treatment.
The cases described in this paper are compared to previous reports from other countries worldwide and contrast the variance in outcome often seen in methanol poisoning. The paper describes two tragic deaths and two lucky survivors, all of whom had consumed a cocktail of methanol and other alcoholic beverages at the same party.
The ICU nurse's role in managing the methanol-intoxicated patient relies on that person's sound knowledge of the unusual biochemical reactions occurring in the body and the need to institute definitive and supportive measures to help both patient and family recover. 相似文献
107.
Trichinella infection and clinical disease 总被引:1,自引:0,他引:1
Clausen MR; Meyer CN; Krantz T; Moser C; Gomme G; Kayser L; Albrectsen J; Kapel CM; Bygbjerg IC 《QJM : monthly journal of the Association of Physicians》1996,89(8):631-636
Trichinellosis is caused by ingestion of insufficiently cooked meat
contaminated with infective larvae of <it>Trichinella</it>
species. The clinical course is highly variable, ranging from no apparent
infection to severe and even fatal disease. We report two illustrative
cases of trichinellosis. Returning to Denmark a few days after having eaten
roasted pork in the Republic of Serbia, a female patient suffered from
severe vomiting, epigastric pain, diarrhoea, and later myalgia, generalized
oedema, and prostration. A biopsy showed heavy infestation with
<it>Trichinella spiralis</it>, 2000 larvae/g of muscle.
Life-threatening cardiopulmonary, renal and central nervous system
complications developed. The patient recovered after several months. Her
husband, who also ate the pork, did not have clinical symptoms, but an
increased eosinophil count and a single larva in a muscle biopsy confirmed
infection. The epidemiology, clinical manifestations, diagnosis, treatment
and prevention of trichinellosis are reviewed.
相似文献
108.
Warren DK Guth RM Coopersmith CM Merz LR Zack JE Fraser VJ 《Critical care medicine》2007,35(2):430-434
OBJECTIVE: To determine the impact of an active surveillance for methicillin-resistant Staphylococcus aureus (MRSA) on contact precaution utilization, as measured by additional number of contact precaution days attributable to the active surveillance program. DESIGN: Prospective cohort study. SETTING: Twenty-four-bed surgical intensive care unit (ICU). PATIENTS: All patients admitted to the surgical ICU. INTERVENTIONS: Nasal cultures for MRSA were performed at admission to a surgical ICU for 19 months. Patients admitted>48 hrs also received weekly and discharge nasal cultures. MEASUREMENTS AND MAIN RESULTS: Clinical data, including start date and initial indication for contact precautions, were prospectively collected. Of 1,893 admissions, 253 (13%) were found to be MRSA-positive during their ICU stay. One hundred forty-six (58%) were identified by nasal culture alone. Compared with the first 10 months of study, the prevalence of MRSA on admission to the ICU during the last 9 months of the study period significantly increased (7.2% vs. 11.4%, p<.001). Acquisition of MRSA by noncolonized patients remained constant between the first 10 months and last 9 months of study (7.0 vs. 5.5 cases per 1000 patient days, p=.29). Two hundred fourteen (6%) of 3461 total contact precaution days in the ICU were attributable to MRSA active surveillance. In sensitivity analyses, the implementation of rapid, same-day results for MRSA active surveillance would increase contact precaution days by 15% compared with no surveillance. If the total number of vancomycin-resistant enterococci patients in the ICU were reduced by 50%, the contact precaution days attributable to active surveillance would increase to 9%. CONCLUSIONS: MRSA active surveillance increased total contact precaution days in this ICU by 6% yet detected 58% of MRSA cases that would have been otherwise missed. Despite an increasing prevalence of MRSA on admission to the ICU, the acquisition rate has remained constant. 相似文献
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110.
Frey N Franz WM Gloeckner K Degenhardt M Müller M Müller O Merz H Katus HA 《Cardiovascular research》2000,47(2):254-264
OBJECTIVE: Familial hypertrophic cardiomyopathy (FHC) due to mutations of cardiac troponin T (cTnT) is associated with a high frequency of sudden death even in the absence of cardiac hypertrophy. To investigate the causal relationship of cTnT mutations and this particular phenotype, we sought to establish a transgenic rat model for the disease. METHODS: Transgenic rats were generated expressing human wild-type cTnT or two truncated cTnT molecules (del ex16, del ex15/16), resulting from an intron 15 splice donor site mutation previously observed in FHC patients. Transgenic rat hearts were characterized by histology, immunohistochemistry and in the 'working heart'. RESULTS: Human wild-type and del ex16 cTnT were stably expressed and incorporated into the sarcomere of transgenic cardiomyocytes. Del ex16 transgenic rats revealed a lower level of expression (4-5%) than human wt cTnT animals (25-40%). In the 'working heart' model del ex16 hearts exhibited significant systolic and diastolic dysfunction without cardiac hypertrophy. In contrast, human wt cTnT hearts showed improved contractile performance and moderate myocardial hypertrophy. After 6 months of daily physical exercise one del ex16 rat died suddenly and three out of five del ex16 hearts revealed ventricular tachycardia/fibrillation. No arrhythmia was observed in human wt cTnT expressors. Myofibrillar disarray was present in del ex16 hearts after training but not in human wild-type cTnT rats or non-transgenic controls. CONCLUSION: A human cTnT deletion overexpressed in transgenic rats exerts a dominant-negative effect and mimics the phenotype of FHC with diastolic dysfunction and arrhythmias. By contrast, human cTnT wild-type animals reveal a gain of function and cardiac hypertrophy without arrhythmias. 相似文献