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21.
Yalniz M Demirel U Orhan C Bahcecioglu IH Ozercan IH Aygun C Tuzcu M Sahin K 《Inflammation》2012,35(3):1213-1221
Effects of nadroparin sodium, a low molecular weight heparin, in colitis was investigated by analyzing proteins implicated
in nuclear factor E2-related factor-2/heme oxygenase-1 (Nrf2/HO-1) and nuclear factor kappa B (NF-κB) pathways. Twenty-eight
rats were used. Colitis was induced by acetic acid (AA). Nadroparin sodium was given to prevention and treatment groups in
addition to AA. Colitis was assessed histologically and levels of proteins were analyzed with Western blot. Nadroparin not
only prevented and ameliorated the AA-induced colitis histopathologically but also decreased expression of colon NF-κB, activator
protein-1, cyclooxygenase-2, tumor necrosis factor-alpha, and IL-6, which were significantly increased in group AA compared
to control. The accumulation of Nrf2 in nuclear fraction and HO-1 found low in group AA was increased with nadroparin (p < 0.05). The mean malondialdehyde level increased with AA and was decreased significantly with nadroparin prevention and
treatment (p < 0.001). Nadroparin sodium has both protective and therapeutic effects against colonic inflammation via exerting anti-oxidative
and anti-inflammatory effects by modulating Nrf2/HO-1 and NF-κB pathways. 相似文献
22.
23.
Poyrazoglu OK Bahcecioglu IH Dagli AF Ataseven H Celebi S Yalniz M 《International journal of clinical practice》2009,63(2):287-291
Objective: Heterotopic gastric mucosa (HGM) is found in the cervical oesophagus, just below the upper oesophageal sphincter, and has generally been overlooked by endoscopists. The objective of the present study is to determine endoscopic prevalence and histopathological and clinical characteristics of HGM and to classify patients according to their clinicopathological features. Method: A total of 911 consecutive patients (436 M and 475 F) who were admitted to our Endoscopy Unit were examined. HGM type and the presence of Helicobacter pylori (Hp) either in the stomach or in the HGM were histopathologically evaluated. Results: Of the 911 patients, 33 (25 M and 8 F) were found to have HGM. HGM prevalence was determined to be 3.6%. On the basis of HGM patients’ symptoms, only dysphagia was significantly correlated with the size of HGM (p < 0.05). Hp was positive in 29.2% of HGM. Clinicopathological classification of the patients showed that 20 patients were HGM type 1 and 13 were HGM type 2. None of the patients had HGM type 3, 4 or 5. Conclusion: Prevalence of HGM was 3.6%. Dysphagia was found related with the size of HGM. This may be associated with larger HGMs’ causing more acid secretion. 相似文献
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25.
Intracranial meningiomas: high-field MR imaging 总被引:6,自引:0,他引:6
Spagnoli MV; Goldberg HI; Grossman RI; Bilaniuk LT; Gomori JM; Hackney DB; Zimmerman RA 《Radiology》1986,161(2):369
26.
Ocular and orbital lesions: surface coil MR imaging 总被引:1,自引:0,他引:1
Bilaniuk LT; Schenck JF; Zimmerman RA; Hart HR Jr; Foster TH; Edelstein WA; Goldberg HI; Grossman RI 《Radiology》1985,156(3):669-674
Nine lesions, four ocular (three melanomas, one hemangioma) and five orbital (two perioptic meningiomas, one hemangioma, one pseudotumor, one mucocele), were evaluated by magnetic resonance surface coil imaging at 1.5 T. Small ocular lesions with 3.9-4.5-mm-elevation were demonstrated. The use of two different pulse sequences resulted in separation of melanoma from adjacent retinal detachment. Contrast obtained between orbital lesions and the adjacent normal structures was better than that demonstrated with high-resolution computed tomography. 相似文献
27.
28.
Cerebral vasculitis: MR imaging and angiographic correlation 总被引:20,自引:0,他引:20
29.
Evaluation of abdominal trauma by computed tomography 总被引:9,自引:2,他引:9
Computed tomography (CT) was used in the evaluation of 100 patients suffering abdominal trauma. The type of trauma was blunt in 78 patients, penetrating in eight, and iatrogenic in 14. Forty per cent of cases had normal CT scans, while 60% showed substantial abdominal or retroperitoneal injuries. Surgery, clinical follow-up, and repeated radiologic examinations confirmed the accuracy of CT, and there were no cases in which medical or surgical management was inappropriately guided by CT. A wide variety of injuries was detected, including 19 splenic, eight hepatic, six pancreatic, 13 renal, 13 retroperitoneal or abdominal wall, and one intraperitoneal. CT has major advantages over plain radiography, radionuclide imaging, and angiography in assessment of trauma-induced injuries. 相似文献
30.