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101.
Bahareh Sadat Yousefsani 《Toxicology mechanisms and methods》2018,28(2):105-114
In this study, we want to understand whether crocin could prevent mitochondrial damage caused by As III. For this purpose, we determined different mitochondrial toxicity endpoints caused by As III. We evaluated mitochondrial ROS formation, lipid peroxidation, mitochondrial membrane potential (MMP) collapse, mitochondrial outer membrane integrity and cytochrome c release. Our results showed that pretreatment with crocin at a concentration of 25?µg/ml significantly (p?0.001) reduced As III-induced mitochondrial ROS formation, lipid peroxidation, MMP collapse and mitochondrial swelling. Crocin also protected the mitochondria by decreasing the mitochondrial outer membrane damage that leads to reduce the amount of cytochrome c release. These results demonstrated that crocin is a promising antidotal candidate by ameliorating As III-induced oxidative stress through mitochondrial targeting. 相似文献
102.
The potential role of unregulated autonomous bladder micromotions in urinary storage and voiding dysfunction; overactive bladder and detrusor underactivity 下载免费PDF全文
Marcus J. Drake Anthony Kanai Dominika A. Bijos Youko Ikeda Irina Zabbarova Bahareh Vahabi Christopher H. Fry 《BJU international》2017,119(1):22-29
The isolated bladder shows autonomous micromotions, which increase with bladder distension, generate sensory nerve activity, and are altered in models of urinary dysfunction. Intravesical pressure resulting from autonomous activity putatively reflects three key variables; the extent of micromotion initiation, distances over which micromotions propagate, and overall bladder tone. In vivo, these variables are subordinate to the efferent drive of the central nervous system. In the micturition cycle storage phase, efferent inhibition keeps autonomous activity generally at a low level, where it may signal ‘state of fullness’, whilst maintaining compliance. In the voiding phase, mass efferent excitation elicits generalised contraction (global motility initiation). In lower urinary tract dysfunction, efferent control of the bladder can be impaired, for example due to peripheral ‘patchy’ denervation. In this case, loss of efferent inhibition may enable unregulated micromotility, and afferent stimulation, predisposing to urinary urgency. If denervation is relatively slight, the detrimental impact on voiding may be low, as the adjacent innervated areas may be able to initiate micromotility synchronous with the efferent nerve drive, so that even denervated areas can contribute to the voiding contraction. This would become increasingly inefficient the more severe the denervation, such that ability of triggered micromotility to propagate sufficiently to engage the denervated areas in voiding declines, so the voiding contraction increasingly develops the characteristics of underactivity. In summary, reduced peripheral coverage by the dual efferent innervation (inhibitory and excitatory) impairs regulation of micromotility initiation and propagation, potentially allowing emergence of overactive bladder and, with progression, detrusor underactivity. 相似文献
103.
Azar Khunda Roopali Karmarkar Bahareh Abtahi Gwen Gonzales Sohier Elneil 《International urogynecology journal》2013,24(7):1201-1204
Introduction and hypothesis
Our aim was to determine the impact of pregnancy on sacral neuromodulation (SNM) and vice versa in patients with Fowler’s syndrome (FS), which is typified by chronic urinary retention (CUR).Methods
We performed a retrospective study of pregnancy in patients with FS who underwent a two-stage SNM implantation. Data were obtained using a standard questionnaire and clinical interview.Results
There were a total of ten patients with 13 pregnancies. The SNM was switched off in ten of the 13 pregnancies, with CUR recurring in nine of the ten pregnancies and recurrent urinary tract infections (UTI) occurring in four of these pregnancies (more than three UTI in the pregnancy). Those in whom the device was left on continued to void normally. One woman had a first trimester miscarriage, eight pregnancies went to term, and four deliveries were premature. Caesarean section was performed in eight pregnancies for obstetric reasons. Four pregnancies resulted in a vaginal delivery. There were no congenital anomalies reported. Following delivery, four of nine women experienced dysfunction of their SNM device when it was switched back on.Conclusion
Turing off the SNM during pregnancy results in recurrence of CUR, with an increased risk of recurrent UTI associated with preterm delivery. This did not impact foetal well-being. The option of keeping the SNM on during pregnancy should therefore be considered, and as caesarean section affects the SNM device, we advise that caesarean section should only be performed for obstetric reasons. 相似文献104.
105.
AbstractThe main aim of the present research, as the first study, was coupling of hydrogen peroxide (H2O2), ferrous ions (Fe2+) and UV irradiation in a photo-Fenton system to degradation two antibiotics (e.g. meropenem and ceftriaxone) from aqueous solution. The tests were carried out at different experimental conditions namely solution pH, iron dosages, H2O2 concentrations, UV light intensities, temperatures, and initial antibiotic concentrations. The degradation rates of 99 and 96.2% were observed for respectively meropenem and ceftriaxone during 60?min treatment. Biodegradability tests illustrated that photo-Fenton system has a high performance in removing organic compounds and biodegradability enhanced remarkably after treatment. 相似文献
106.
Saeed Hosseini Bahareh Amirkalali Neda Nayebi Ramin Heshmat Bagher Larijani 《Nutrition in clinical practice》2006,21(5):518-521
BACKGROUND: We assessed the nutrition status of patients on admission and monitored changes during hospitalization at Shariatri Educational Hospital, Tehran, Iran. METHODS: One hundred fifty-six randomly selected patients from 9 different wards were assessed. Body mass index (BMI) and body composition (based on bioelectrical impedance) were measured on admission and discharge. A questionnaire was also completed to evaluate general physical, psychological, and living status of the patients. Medical records were audited to identify when nutrition consultation, nutrition support, and nutrition-related laboratory factors (serum levels of total lymphocyte count [TLC] and albumin) were ordered. Frequency and paired t-test were used to analyze data. RESULTS: Undernutrition (BMI <18.5 kg/m(2)) was present in 5.7% of the patients on admission, and severe undernutrition (BMI <16 kg/m(2)) existed in 0.6%. When discharged, 11% of patients were undernourished, and the prevalence of severe undernutrition increased to 1.3%. Average body weight and BMI decreased significantly during hospitalization (p < .001). Body composition analysis showed a significant reduction in body protein mass (p < .001). During hospitalization, body water percentile decreased and body fat percentile increased but not significantly. Only 1 patient was supported with parenteral nutrition (PN) and 1 with enteral nutrition. Orders for nutrition consultation were present in 1.9%, TLC levels in 10.8%, and serum albumin levels in 7% of the patient medical records surveyed. CONCLUSIONS: Undernutrition increased in patients during hospitalization. According to the low rate of nutrition-related orders, one potential cause of worsening nutrition status may be inadequate medical staff awareness about the importance of nutrition in hospitalized patients. 相似文献
107.
John E. Speich PhD Tufan Tarcan MD PhD Hikaru Hashitani MD PhD Bahareh Vahabi PhD Karen D. McCloskey PhD Karl-Erik Andersson MD PhD Alan J. Wein MD PhD Lori A. Birder PhD 《Neurourology and urodynamics》2020,39(Z3):S16-S22
Several studies indicate that pelvic ischemia and oxidative stress may play a significant role in lower urinary tract dysfunction (LUTD), including detrusor overactivity (DO)/overactive bladder (OAB) and detrusor underactivity (DU)/underactive bladder (UAB). The present article addresses proposal 1: “Are oxidative stress and ischemia significant causes of bladder damage leading to LUTD?” from the 2019 International Consultation on Incontinence—Research Society (ICI-RS) meeting. Bladder ischemia in animals and humans is briefly described, along with the proposed progression from ischemia to LUTD. Bladder ischemia is compared with ischemia of other organs, and the ongoing development of pelvic ischemia animal models is discussed. In addition, the distribution of blood within the bladder during filling and voiding and the challenges of quantification of blood flow in vivo are described. Furthermore, oxidative stress, including potential biomarkers and treatments, and challenges regarding antioxidant therapy for the treatment of LUTD are discussed. Finally, seven critical research questions and proposed studies to answer those questions were identified as priorities that would lead to major advances in the understanding and treatment of lower urinary tract symptoms (LUTS)/LUTD associated with pelvic ischemia and oxidative stress. 相似文献
108.
109.
Mohammad Taghi Mansouri Bahareh Naghizadeh Behnam Ghorbanzadeh 《Indian journal of pharmacology》2014,46(4):404-408
Objective:
Ellagic acid (EA), a major polyphenolic compound of pomegranate juice, produces antinociceptive effects, which are mediated through opioidergic and nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathways. The present study was conducted to elucidate the peripheral antinociceptive effect of EA alone and in combination with sildenafil in the rat formalin test.Materials and Methods:
Pain was produced by intraplantar injection of formalin (2.5%) in rats and nociceptive behavior was measured as the number of flinches every 5 min in 60 min after injection.Results:
Local administration of EA and sildenafil dose-dependently increased the nociception threshold in both phases of the test. Moreover, sub-effective doses of sildenafil (25 or 50 mcg/paw, i.p.) significantly and dose-dependently enhanced the antinociception induced by a sub-effective dose of EA (60 mcg/paw, i.pl.) in both phases of the test. The antinociception produced by these drugs alone, or in combination, was due to a peripheral site of action, since the administration in the contralateral paw was ineffective.Conclusion:
Our results suggest that EA has local peripheral antinociceptive activity, and enhancement of this effect with sildenafil probably occurs through the inhibition of cGMP metabolism.KEY WORDS: Ellagic acid, formalin, peripheral antinociception, sildenafil 相似文献110.
Bahareh Attaran Tahereh Falsafi Ali N. Moghaddam 《Saudi Journal Of Gastroenterology》2016,22(2):161-168