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排序方式: 共有879条查询结果,搜索用时 15 毫秒
871.
872.
SK Selvanathan A Shenton R Ferner AJ Wallace SM Huson RT Ramsden DG Evans 《Clinical genetics》2010,77(2):163-170
Selvanathan SK, Shenton A, Ferner R, Wallace AJ, Huson SM, Ramsden RT, Evans DG. Further genotype–phenotype correlations in neurofibromatosis 2. Neurofibromatosis 2 (NF2) is caused by mutations in the NF2 gene predisposing carriers to develop nervous system tumours. Different NF2 mutations result in either loss/reduced protein function or gain of protein function (abnormally behaving mutant allele i.e. truncated protein potentially causing dominant negative effect). We present a comparison between the clinical presentations of patients with mutations that are predicted to produce truncated protein (nonsense/frameshift mutations) to those that results in loss of protein expression (large deletions) to elucidate further genotype–phenotype correlations in NF2. Patients with nonsense/frameshift mutations have a younger age of diagnosis and a higher prevalence/proportion of meningiomas (p = 0.002, p = 0.014), spinal tumours (p = 0.004, p = 0.004) and non‐VIII cranial nerve tumours (p = 0.006, p = 0.003). We also found younger age of diagnosis of vestibular schwannomas (p = 0.007), higher mean numbers of cutaneous lesions (p = 0.003) and spinal tumours (p = 0.006) in these patients. With respect to NF2 symptoms, we found younger age of onset of hearing loss (p = 0.010), tinnitus (p = 0.002), paraesthesiae (p = 0.073), wasting and weakness (p = 0.001) and headaches (p = 0.049) in patients with nonsense/frameshift mutations. Our comparison shows, additional, new correlations between mutations in the NF2 gene and the NF2 disease phenotype, and this further confirms that nonsense/frameshift mutations are associated with more severe NF2 symptoms. Therefore patients with this class of NF2 mutation should be followed up closely. 相似文献
873.
Background and Aim:
Recent studies on various populations indicate that lack of sleep is one of the potential risk factors predisposing the youth to obesity. Since there is a significant rise in obesity among Indian youth and because research indicating the role of sleep in development of obesity among Indian population is scant, the current study was undertaken to assess the effect of sleep duration on adiposity among Gujarati Indian adolescents.Materials and Methods:
A randomized cross-sectional study was done on 489 voluntarily participating Indian adolescents in the age group of 16-19 years. Participants were grouped into two categories 1). Adequate Sleep Duration at Night (more than seven hours, ASDN) and 2) Inadequate Sleep Duration at Night (less than seven hours, IASDN) as reported by the participants. The participants were later assessed for adiposity in terms of BMI, BF %, FM, FMI and waist circumference, meal frequency per day and physical activity status.Results:
In both boys as well as girls, the BMI, BF%, FM and FMI were significantly lower in the ASDN group than the IASDN group. However, there was an insignificant difference in the meal frequency and physical activity status between the ASDN and IASDN group.Conclusion:
Inadequate sleep duration increases adiposity among Gujarati Indian adolescents but further studies are required to find out the mechanisms through which sleep affects adiposity in this population. 相似文献874.
875.
McLaren J; Dealtry G; Prentice A; Charnock-Jones DS; Smith SK 《Human reproduction (Oxford, England)》1997,12(6):1307-1310
Endometriosis is characterized by an increase in the number, activation and
secretory activity of peritoneal fluid macrophages. Factors regulating the
activation of these cells may be important in the pathophysiology of this
disease. In this study we measured by enzyme- linked immunosorbent assay
the concentrations of the macrophage inhibitory factor interleukin (IL)-13
in the peritoneal fluid of women with and without endometriosis. It was
found that women with endometriosis had significantly lower amounts of
IL-13 (95 +/- 9.8 pg/ml) in peritoneal fluid, compared with women without
endometriosis (115 +/- 30 pg/ml) (P < 0.01). No cycle-specific variation
was evident for either group. Another macrophage inhibitory interleukin
(IL-10) was also measured, but no differences between women with (16.1 +/-
13.2 pg/ml) or without (10.3 +/- 5.6 pg/ml) endometriosis were seen. The
immunolocalization of IL-13 was assessed in eutopic and ectopic endometrium
and in isolated peritoneal fluid cells. Glandular epithelial cells and
stromal cells in both eutopic and ectopic endometrium were immunopositive
for IL-13. No cycle-specific differences in the immunolocalization of IL-13
were seen. In conclusion, the reduced amounts of IL-13 in the peritoneal
fluid of women with endometriosis may lead to a lack of suppression of
macrophage activation, thereby contributing to the overall pathogenesis of
this disease.
相似文献
876.
KC Saikia SK Bhuyan TD Bhattacharya M Borgohain P Jitesh F Ahmed 《Indian Journal of Orthopaedics》2011,45(5):417-421
Background:
The locking compression plate (LCP) with combination holes is a newer device in fracture fixation. We undertook a study comparing the LCP with limited contact dynamic compression plate (LC-DCP) in the treatment of diaphyseal fractures of both bones of the forearm.Materials and Methods:
This is a prospective comparative study, 36 patients (18 in each group) with fractures of both the forearm bones (72 fractures) were treated with one of the two devices. The average age of the patients was 30.5 years (range 16–60 years) with mean followup of 2.1 years (range 1.5–2.8 years). The patients were assessed for fracture union and function and complications and by Disabilities of the Arm, Shoulder and Hand (DASH) score for patient related outcome at the latest followup.Results:
There was no significant difference in two groups with respect to the range of movements or grip strength. One case had delayed union (LC-DCP group) and another had synostosis (LCP group). Plate removal was done in four cases within the study period with no refracture till the presentation of this report.Conclusion:
LC plating is an effective treatment option for fractures of both bones of forearm. The present study could not prove its superiority over LC-DCP. 相似文献877.
878.
D Routh RP Singh BM Sekhar SK Sharma D Kumar 《Hellēnikē cheirourgikē. Acta chirurgica Hellenica》2018,90(5):254-260
Aim
To study postoperative complications in patients undergoing binding pancreaticogastrostomy (PG) following pancreaticoduodenectomy (PD) in a tertiary hospital in India.Methods
A prospective study was conducted of patients undergoing binding PG following PD over a 2-year period. The demographic and preoperative laboratory data of the patients, the type of procedure, complications, hospital mortality, duration of hospital stay, and postoperative interventional procedures or reoperations were recorded and examined for associations. Statistical analysis was performed using Stata 9.0 (College Station, Texas, USA).Results
Over 2 years, 47 patients, 29 men and 18 women, mean age 55.4 ± 11.6 years, who underwent binding PG following PD were included in the study. Postoperative complications were recorded in 23 patients and there were 2 deaths in the first 30 days following surgery. The most frequent complication was delayed gastric emptying (DGE), observed in 11 patients (23%), with a mean duration of 13.5 ± 2.6 days. Post-operative pancreatic leak, which was detected in 3 patients (6%), did not appear to be influenced by the pancreatic duct diameter or the softness of the pancreas, which are known independent factors responsible for pancreatic leak.Conclusion
The technique of binding PG is simple, safe, easy to perform, and less traumatic to the pancreatic stump, with fewer complications, and it can be performed without significant adverse outcome, irrespective of pancreatic stump texture or pancreatic duct diameter.879.
SK Hung 《Focus on Alternative and Complementary Therapies》2012,17(1):59-60
Gupta AK, Acharya K, Sancheti PS, Joshi RS. A double‐blind, randomized, multicentric, placebo‐controlled clinical trial of Antarth, a phytomedicine, in the treatment of osteoarthritis. Indian J Pharmacol 2011; 43: 69–72. 相似文献