全文获取类型
收费全文 | 1649篇 |
免费 | 99篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 37篇 |
妇产科学 | 74篇 |
基础医学 | 179篇 |
口腔科学 | 31篇 |
临床医学 | 141篇 |
内科学 | 472篇 |
皮肤病学 | 26篇 |
神经病学 | 169篇 |
特种医学 | 45篇 |
外科学 | 133篇 |
综合类 | 4篇 |
预防医学 | 88篇 |
眼科学 | 16篇 |
药学 | 196篇 |
中国医学 | 7篇 |
肿瘤学 | 138篇 |
出版年
2024年 | 1篇 |
2023年 | 15篇 |
2022年 | 32篇 |
2021年 | 56篇 |
2020年 | 32篇 |
2019年 | 48篇 |
2018年 | 53篇 |
2017年 | 43篇 |
2016年 | 49篇 |
2015年 | 68篇 |
2014年 | 71篇 |
2013年 | 87篇 |
2012年 | 140篇 |
2011年 | 135篇 |
2010年 | 69篇 |
2009年 | 53篇 |
2008年 | 95篇 |
2007年 | 108篇 |
2006年 | 99篇 |
2005年 | 109篇 |
2004年 | 72篇 |
2003年 | 97篇 |
2002年 | 74篇 |
2001年 | 19篇 |
2000年 | 20篇 |
1999年 | 18篇 |
1998年 | 17篇 |
1997年 | 5篇 |
1996年 | 10篇 |
1995年 | 9篇 |
1994年 | 4篇 |
1993年 | 4篇 |
1992年 | 11篇 |
1991年 | 8篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1988年 | 6篇 |
1987年 | 6篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 1篇 |
1983年 | 4篇 |
1964年 | 1篇 |
排序方式: 共有1764条查询结果,搜索用时 62 毫秒
21.
Letizia Mazzini Daniela Testa Carla Balzarini Gabriele Mora 《Journal of neurology》1994,241(4):223-227
Based on the hypothesis that free radicals play a general role in the neurodegenerative process in motor neuron disease, we tested selegiline in a group of patients affected by amyotrophic lateral sclerosis (ALS) to examine whether it might modify the progression of the disease. Patients were admitted if they were 25–80 years old and had a confirmed diagnosis of ALS with symptoms lasting no longer than 24 months. Patients with familial ALS, pure progressive bulbar palsy, primary lateral sclerosis or progressive muscle atrophy were excluded; a total of 111 patients were recruited. Fifty-three patients were randomly assigned to receive the drug (selegiline 10 mg/day orally for 6 months) and the remaining 58 were considered ALS controls. Mortality was similar in the two groups (4 and 5 patients respectively), though the difference was not statistically significant. Among the survivors, mean MRC and Norris disability scores and forced vital capacity were fairly similar in the two groups at all times and no statistically significant difference between treated and untreated patients was found. The results did not change when the data were related to age, duration and characteristics of onset of the disease. The rate of progression was significantly more rapid in patients with bulbar symptoms in both groups. Our data do not show any significant effect of selegiline in modifying the progression of ALS. 相似文献
22.
23.
Letizia Polito Massimo Bortolotti Daniele Mercatelli Maria Giulia Battelli Andrea Bolognesi 《Toxins》2013,5(10):1698-1722
Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and mechanisms of action of saporin-S6 have been well characterized, and it has been widely employed in the construction of conjugates and immunotoxins for different purposes. These immunotoxins have shown many interesting results when used in cancer therapy, particularly in hematological tumors. The high enzymatic activity, stability and resistance to conjugation procedures and blood proteases make saporin-S6 a very useful tool in cancer therapy. High efficacy has been reported in clinical trials with saporin-S6-containing immunotoxins, at dosages that induced only mild and transient side effects, which were mainly fever, myalgias, hepatotoxicity, thrombocytopenia and vascular leak syndrome. Moreover, saporin-S6 triggers multiple cell death pathways, rendering impossible the selection of RIP-resistant mutants. In this review, some aspects of saporin-S6, such as the chemico-physical characteristics, the structural properties, its endocytosis, its intracellular routing and the pathogenetic mechanisms of the cell damage, are reported. In addition, the recent progress and developments of saporin-S6-containing immunotoxins in cancer immunotherapy are summarized, including in vitro and in vivo pre-clinical studies and clinical trials. 相似文献
24.
25.
Francesco Venturelli Giuliano Carrozzi Letizia Sampaolo Lara Bolognesi Sandro Baldissera Nicoletta Bertozzi Stefano Campostrini Benedetta Contoli Gianluigi Ferrante Maria Masocco Valentina Minardi Angelo D'Argenzio Pirous F Moghadam Luana Penna Alberto Perra Elisa Quarchioni Mauro Ramigni Massimo O Trinito Stefania Salmaso 《Lancet》2014
BackgroundInfluenza is an important public health problem, with potential severe consequences among people with chronic diseases. The aim of this study was to obtain reliable measures of seasonal influenza vaccine uptake in this population, otherwise not available in Italy.MethodsProgressi delle Aziende Sanitarie per la Salute in Italia (PASSI) is a nationwide surveillance system of health-related behaviours and acceptance of preventive interventions (including influenza immunisation) offered by the Italian National Health Service. Data are collected with telephone interviews at local health unit level for supporting local activities. The survey sample is randomly selected from local health unit lists of adult residents. The trend of annual vaccine coverage since 2008 was estimated for people aged 18–64 years who reported having at least one chronic disease. To obtain a sufficient sample size in subgroups, we analysed the characteristics of vaccinated people in the 2010–13 cumulative dataset. Univariate, multivariate, and logistic regression analyses were undertaken.FindingsIn 2008–13, 13 659 individuals with at least one chronic disease were interviewed. Vaccination coverage fell significantly from 29·7% (95% CI 27·2–32·4) in 2007–08 to 19·9% (18·0–22·1) in 2012–13. During 2010–13, the overall proportion of vaccinated people with a chronic disease was 25·6% (24·5–26·7). Vaccine coverage of people with diabetes (34·3%, 31·7–36·9) or cardiovascular diseases (31·8%, 29·6–34·2) was greater than that of people affected by renal failure, respiratory diseases, tumours, or chronic liver diseases (26·5% [22·5–30·7], 24·9% [23·2–26·7], 22·2% [20·0–24·6], and 20·6% [17·5–24·6], respectively). Vaccination coverage increased with age (from 13·1% [11·0–15·5] in the 18–34 year age group to 33·4% [31·9–35·1] in people aged 50–64 years); it was higher among people with a low educational level than among those with a high educational level, higher in those having economic difficulties than in those with no economic difficulties, and higher among Italian citizens than among non-citizens.InterpretationIn the past few years, prevalence of influenza vaccination in Italian adults with at least one chronic disease was well below the Ministry of Health's goal (75% minimum) and showed a downward trend. A major reason of this evolution is probably the changing public perception of the benefits and risks of vaccines. PASSI is a source of useful data not otherwise available for public health intervention.FundingItalian Ministry of Health. 相似文献
26.
Alberto Berardi Cecilia Rossi Maria Letizia Bacchi Reggiani Annalisa Bastelli Maria Grazia Capretti Claudio Chiossi 《The journal of maternal-fetal & neonatal medicine》2017,30(14):1739-1744
Introduction: The prevalence of maternal group-B-streptococcus (GBS) colonization and risk factors (RFs) for neonatal early-onset disease (EOD) in Europe are poorly defined. Large-scale information concerning adherence to recommendations for preventing GBS-EOD are lacking.Materials and methods: This was a 3-month retrospective area-based study including all regional deliveries ≥35 weeks' gestation (in 2012). The sensitivity, specificity, positive and negative predictive values, odds ratio and receiver operating characteristic (ROC) curve for intrapartum antibiotic prophylaxis (IAP) among full-term and preterm deliveries and prolonged membrane rupture (PROM) were calculated.Results: Among 7133 women, 259 (3.6%) were preterm (35–36 weeks' gestation). Full-term women were 6874, and 876 (12.7%) had at least 1?RF. Most women (6495) had prenatal screening and 21.4% (1390) were GBS positive.IAP was given to 2369 (33.2%) women (preterm, n?=?166; full term, n?=?2203). Compared to full-term, preterm women were less likely to receive IAP when indicated (73.2% versus 90.3%, p?0.01). Full-term women represented the largest area under the curve (AUC, 0.87). PROM showed the highest sensitivity (98.6%), but the lowest specificity (6.9%) and AUC (0.53).Conclusions: Large-scale prenatal screening and IAP are feasible. Women delivering preterm are less likely to receive IAP when indicated. Most unnecessary antibiotics are given in cases of PROM. 相似文献
27.
28.
29.
30.