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Maria Fiorella Contarino MD Elles Berger‐Plantinga MD Elisabeth M.J. Foncke MD Katja Ritz MSc Jonke Mellema MD Frank Baas PhD Johannes D. Speelman MD PhD Marina A.J. Tijssen MD PhD 《Movement disorders》2008,23(14):1998-2003
We describe a large family with a primary focal dystonia from a small Dutch village on a former island. Twenty‐four individuals spanning three generations were examined by two movement‐disorder neurologists. Two other movement‐disorder neurologists evaluated the videos independently. Subjects were classified as “affected,” “possibly affected,” or “not affected.” A diagnosis was defined if all the neurologists agreed on the definition. Eight definitely affected and four possibly affected subjects were detected. Clinical presentation consisted of mild cranio‐cervical‐brachial dystonia. Mean age at onset was 45.5 years (range, 39–56). Mean BFMDRS motor score was 4.4 (range, 1–8). Mean TWSTRS score (part I) was 11.3 (range, 8–23). Mutations in DYT1 gene and in the ε‐sarcoglycan (SGCE) genes were not detected. We could not find linkage to the dominant DYT6, DYT7, DYT13, or the recessive DYT16 loci. The identification and accurate clinical evaluation of large dystonia families not linked to known genes is crucial for further advancement in molecular genetic characterization of focal dystonia. © 2008 Movement Disorder Society 相似文献
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Di Chiro G; Girton ME; Frank JA; Dietz MJ; Gansow OA; Wright DC; Dwyer AJ 《Radiology》1986,160(1):221-222
Canine cerebrospinal fluid rhinorrhea, which occurs frequently in purebred beagles, was demonstrated in two dogs on magnetic resonance images after cisternal introduction of gadolinium-DTPA dimeglumine. 相似文献
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Judith Aston is a somatic pioneer. She began as a dancer and physical education teacher. Severe accidents prompted her to seek out Ida Rolf who not only worked on her but also entrusted her with developing the Rolf movement curriculum. She next followed her instincts and refined her concepts for helping people problem solve. For the past 28 years she has continued to improve the Aston Paradigm® combining bodywork, ergonomic supports, exercises and movement therapy. 相似文献
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Rasmus Cleemann Joan E. Bechtold Mette Sorensen Kjeld Soballe Jorgen Baas 《The Journal of arthroplasty》2018,33(4):1215-1221.e1
Background
Impacted bone allograft is used to restore lost bone in total joint arthroplasties. Bone morphogenetic proteins (BMPs) can induce new bone formation to improve allograft incorporation, but they simultaneously invoke a seemingly dose-dependent allograft resorption mediated by osteoclasts. Bisphosphonates effectively inhibit osteoclast activity. Predicting allograft resorption when augmented with bone morphogenetic protein 2 (BMP-2), we intended to investigate whether a balanced bone metabolism was achievable within a range of BMP-2 doses with systemic zoledronate treatment.Methods
Implants were coated with 1 of 3 BMP-2 doses (15 μg, 60 μg, and 240 μg) or left untreated. Implants were surrounded by a 2.5-mm gap filled with impacted morselized allograft. Each of the 12 dogs included received 1 of each implant (15 μg, 60 μg, 240 μg, and untreated), 2 in each proximal humerus. During the 4-week observation period, zoledronate intravenous (0.1 mg/kg) was administered to all animals 10 days after surgery as anticatabolic treatment. Implant osseointegration was evaluated by histomorphometry and mechanical push-out tests.Results
Untreated implants had the best mechanical fixation and superior retention of allograft as compared to any of the BMP-2 implants. Both mechanical implant fixation and retention of allograft decreased significantly with BMP-2 dose increments. Surprisingly, there was no difference among the treatment groups in the amount of new bone.Conclusion
The use of BMP-2 to augment impaction-grafted implants cannot be recommended even when combined with systemic zoledronate. 相似文献89.
Martijn Baas Pieter R. Zwanenburg Steven E.R. Hovius Christianne A. van Nieuwenhoven 《The Journal of hand surgery》2018,43(9):869.e1-869.e11
90.
Timely diagnosis of osseous tumors is essential in providing proper management. Appropriate imaging studies are essential
to this process, however, if inconclusive, they can be superceded by information obtained through the patient history and
physical examination.
Disclaimer: Dr. Bhandari's salary was provided, in part, by a scholarship from the R.K Frasier Research Foundation 相似文献