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Sheena G Sullivan Sandra Carlson Allen C Cheng Monique BN Chilver Dominic E Dwyer Melissa Irwin Jen Kok Kristine Macartney Jennifer MacLachlan Cara Minney-Smith David Smith Nigel Stocks Janette Taylor Ian G Barr 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2020,25(47)
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Health professional students' rural placement satisfaction and rural practice intentions: A national cross‐sectional survey 下载免费PDF全文
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Wei Hong WANG Fu Lian HU Benjamin CY WONG Douglas E BERG Shiu‐Kum LAM 《Journal of digestive diseases》2002,3(4):172-177
OBJECTIVE: The interactions between non‐steroidal anti‐inflammatory drugs and Helicobacter pylori have not been sufficiently documented to date. The aim of this study was to investigate the possible effects of aspirin and indometacin on the growth of H. pylori and to determine the effects of aspirin on the susceptibility of H. pylori to some antimicrobials. METHODS: Kinetic studies were performed by inoculating strains of H. pylori in brucella broth with different concentrations of aspirin and indometacin. Growth of bacteria in the broth was assessed spectrophotometrically and by viable colony counts after incubation for 24 and 48 h. Bacterial morphology was determined by Gram stain under light microscopy. The minimal inhibitory concentration (MIC) of aspirin and indometacin was determined by the standard agar dilution method. The MIC of amoxicillin, clarithromycin and metronidazole was measured in the presence and absence of aspirin by the E‐test method. RESULTS: Kinetic studies revealed that aspirin and indometacin inhibited the growth of H. pylori in a dose‐dependent manner. The bactericidal activity of these agents was expressed by cell lysis. Aspirin at 400 µg/mL produced an almost 2‐log decrease in the number of CFU/mL at 48 h. Similar inhibitory effects were obtained when 100 µg/mL indometacin was tested. The MIC at which 90% of H. pylori was inhibited was 512 µg/mL and 128 µg/mL for aspirin and indometacin, respectively. Increased susceptibility of H. pylori to amoxicillin, clarithromycin and metronidazole was found in the presence of aspirin. CONCLUSIONS: Aspirin and indometacin could significantly inhibit the growth of H. pylori when incubated in brucella broth in vitro. A subinhibitory concentration of aspirin enhanced the susceptibility of H. pylori to some antimicrobial agents. 相似文献
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Cristina Thompson MBA BA RN RM Elizabeth Halcomb PhD Grad Cert ICNurs Grad Cert HE BN RN FACN Malcolm Masso PhD MPH MNA BSc RN 《Scandinavian journal of caring sciences》2023,37(3):611-627
Background
Social connection is a fundamental human need. Its absence can lead to loneliness and social isolation, adversely impacting health and well-being. Given their regular contact and trusted relationships with older people, practitioners delivering community-based primary care are well-positioned to address this issue. However, their contribution to addressing loneliness and social isolation is unclear.Aim
This integrative review explores the contribution of the primary care workforce to interventions aimed at reducing loneliness and social isolation in community-dwelling older people.Method
Using an integrative review method, Scopus, Web of Science, CINAHL and PubMed were searched for original research published between 2000 and 2022. Fourteen papers reporting 13 primary studies were appraised for methodological quality and included in the review. Data were extracted into a summary table and analysed using thematic analysis.Results
Included studies came from over six countries. Internationally, primary care services have diverse structures, funding and workforces influencing their response to loneliness and social isolation. All but one intervention was multi-component, with ten studies including a group-based activity and three providing primarily individual-level activities. Only six studies reported reductions in loneliness following the intervention. Three themes were identified: characteristics of interventions; implementation context, barriers and facilitators; and differing contributions of primary care practitioners in addressing loneliness and social isolation of older people.Conclusion
There is increasing demand and scope for primary care practitioners to assist lonely and socially isolated older people. It is important to understand how to equip and incentivise these practitioners to routinely identify, assess and respond to lonely and socially isolated older people despite varying implementation contexts. There is a need for further research that explores how the primary care team can be better utilised to deliver effective interventions that reduce the health impacts of loneliness and social isolation. 相似文献40.
E. Rosser RN DPhil MN RM Dip N Ed Dip RM PFHEA E. Buckner RN PhD CNE AE-C FNAP T. Avedissian RN MSN D.S.K. Cheung BN MSc PhD K. Eviza RN MSN T. B. Hafsteinsdóttir RN PhD M.Y. Hsu RN PhD MSc M. N. Kirshbaum RN BSc MSc PhD GDip Health Ed Dip Onc Dip Counselling Dip CBT FHEA C. Lai RN PhD Y.C. Ng PhD J. Ramsbotham RN PhD MN S. Waweru RN MSN FNP-BC 《International nursing review》2020,67(4):484-494