全文获取类型
收费全文 | 4217篇 |
免费 | 294篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 168篇 |
妇产科学 | 129篇 |
基础医学 | 458篇 |
口腔科学 | 101篇 |
临床医学 | 335篇 |
内科学 | 888篇 |
皮肤病学 | 60篇 |
神经病学 | 345篇 |
特种医学 | 163篇 |
外国民族医学 | 5篇 |
外科学 | 767篇 |
综合类 | 119篇 |
一般理论 | 1篇 |
预防医学 | 260篇 |
眼科学 | 99篇 |
药学 | 283篇 |
中国医学 | 31篇 |
肿瘤学 | 285篇 |
出版年
2023年 | 39篇 |
2022年 | 90篇 |
2021年 | 150篇 |
2020年 | 96篇 |
2019年 | 117篇 |
2018年 | 149篇 |
2017年 | 94篇 |
2016年 | 115篇 |
2015年 | 124篇 |
2014年 | 177篇 |
2013年 | 212篇 |
2012年 | 293篇 |
2011年 | 320篇 |
2010年 | 210篇 |
2009年 | 174篇 |
2008年 | 211篇 |
2007年 | 226篇 |
2006年 | 224篇 |
2005年 | 255篇 |
2004年 | 204篇 |
2003年 | 176篇 |
2002年 | 157篇 |
2001年 | 75篇 |
2000年 | 69篇 |
1999年 | 80篇 |
1998年 | 26篇 |
1997年 | 26篇 |
1996年 | 16篇 |
1995年 | 28篇 |
1994年 | 16篇 |
1993年 | 19篇 |
1992年 | 27篇 |
1991年 | 20篇 |
1990年 | 25篇 |
1989年 | 20篇 |
1988年 | 18篇 |
1987年 | 17篇 |
1986年 | 23篇 |
1985年 | 19篇 |
1984年 | 14篇 |
1983年 | 12篇 |
1982年 | 14篇 |
1981年 | 10篇 |
1979年 | 12篇 |
1978年 | 20篇 |
1976年 | 10篇 |
1973年 | 10篇 |
1972年 | 13篇 |
1969年 | 15篇 |
1966年 | 9篇 |
排序方式: 共有4535条查询结果,搜索用时 15 毫秒
41.
42.
43.
44.
Hatice Ar G Ertugrul Mirz Osman A Polat Sarper Karakucuk Ayse Oner Koray Gumus 《国际眼科》2015,8(1):77-80
AIM: To evaluate the effects of chronic smoking on color vision in young subjects.
METHODS: This study included 91 smokers and 88 non-smokers (a total of 179 volunteers) without any ophthalmologic and systemical disorders. The subjects were between 18-40 years of age with a best corrected visual acuity (BCVA) of 20/20, normal anterior and posterior segment examinations and normal intraocular pressure. The color vision of the subjects were evaluated with Farnsworth-Munsell 100 Hue test (FMHT). The total error scores and axis calculation were performed for each subject and the results correlated.
RESULTS: Mean age and the standard deviation was 28±5y in the smokers group, and 26.7±5.5y in the control group (P=0.101). Sex distribution was similar in the two groups (P=0.365). There was no significant correlation between age and FMHT total error scores (P=0.069). Median of FMHT total error scores of smokers and non-smokers were 65 and 50.50, respectively. FMHT total error scores was found significantly higher in smokers than non-smokers (P=0.004). There was no statisticaly significant difference between smoker and non-smoker groups with respect to axis ratio calculation (P=0.611). There was no significant correlation with FMHT total error scores with neither smoking duration nor number of cigarettes smoked per day (P=0.405, P=0.454, respectively).
CONCLUSION: This study suggested that chronic smoking affects the color vision of young smokers but this may not be sector selective. 相似文献
45.
AndrewJ. Stott Michel C. Maillard Vahri Beaumont David Allcock Omar Aziz Alexander H. Borchers Wesley Blackaby Perla Breccia Gillian Creighton-Gutteridge Alan F. Haughan Rebecca E. Jarvis Christopher A. Luckhurst Kim L. Matthews George McAllister Scott Pollack Elizabeth Saville-Stones Amanda J. Van de Poël Huw D. Vater Julie Vann Rachel Williams Dawn Yates Ignacio Muoz-Sanjun Celia Dominguez 《ACS medicinal chemistry letters》2021,12(3):380
Using an iterative structure–activity relationship driven approach, we identified a CNS-penetrant 5-(trifluoromethyl)-1,2,4-oxadiazole (TFMO, 12) with a pharmacokinetic profile suitable for probing class IIa histone deacetylase (HDAC) inhibition in vivo. Given the lack of understanding of endogenous class IIa HDAC substrates, we developed a surrogate readout to measure compound effects in vivo, by exploiting the >100-fold selectivity compound 12 exhibits over class I/IIb HDACs. We achieved adequate brain exposure with compound 12 in mice to estimate a class I/IIb deacetylation EC50, using class I substrate H4K12 acetylation and global acetylation levels as a pharmacodynamic readout. We observed excellent correlation between the compound 12 in vivo pharmacodynamic response and in vitro class I/IIb cellular activity. Applying the same relationship to class IIa HDAC inhibition, we estimated the compound 12 dose required to inhibit class IIa HDAC activity, for use in preclinical models of Huntington’s disease. 相似文献
46.
47.
Local production of anti-vibrio cholerae mucosal antibody in reproductive tract tissues after cholera 总被引:4,自引:0,他引:4
Ryan ET Bridges EA Crean TI Gausia K Hamadani JD Aziz A Hawkes S Begum M Bogaerts J Faruque SM Salam MA Fuchs GJ Calderwood SB 《The Journal of infectious diseases》2001,184(5):643-647
To investigate whether intestinal presentation of an antigen by Vibrio cholerae, a noninvasive organism, could induce an anatomically distant mucosal immune response in reproductive tract tissues, the endocervical immune responses of women in Bangladesh were evaluated after cholera. Endocervical secretions were analyzed for secretory IgA (sIgA) antibody against the B subunit of cholera toxin (CtxB) in 9 women with cholera and 8 women with diarrhea caused by neither V. cholerae nor heat labile enterotoxin-producing Escherichia coli. Women infected with V. cholerae developed significant sIgA anti-CtxB responses in endocervical samples (P< or =.02). Antibody subtype analysis of endocervical IgA was consistent with local mucosal production (P< or =.001). Women with cholera did not develop sIgA anti-CtxB responses in serum. The ability to generate specific mucosal immune responses in reproductive tract tissues after intestinal presentation of antigen could facilitate development of vaccines effective against reproductive tract pathogens. 相似文献
48.
Inayat Ur Rehman Raheel Ahmed Aziz Ur Rahman David Bin Chia Wu Syed Munib Yasar Shah Nisar Ahmad Khan Ateeq Ur Rehman Learn Han Lee Kok Gan Chan Tahir Mehmood Khan 《Medicine》2021,100(21)
Background:Chronic kidney disease (CKD)-associated pruritus (CKD-aP) contributes to poor quality of life, including reduced sleep quality and poor sleep quality is a source of patient stress and is linked to lower health-related quality of life. This study aimed to investigate the effectiveness of zolpidem 10 mg and acupressure therapy on foot acupoints to improve the sleep quality and overall quality of life among hemodialysis patients suffering from CKD-aP.Method:A multicenter, prospective, randomized, parallel-design, open label interventional study to estimate the effectiveness of zolpidem (10 mg) oral tablets versus acupressure on sleep quality and quality of life in patients with CKD-aP on hemodialysis. A total of 58 hemodialysis patients having sleep disturbance due to CKD-aP completed the entire 8-week follow-up. The patients were divided into a control (acupressure) group of 28 patients and an intervention (zolpidem) group of 30 patients.Results:A total of 58 patients having CKD-aP and sleep disturbance were recruited. In the control group there was a reduction in the PSQI score with a mean ± SD from 12.28 ± 3.59 to 9.25 ± 3.99, while in the intervention group the reduction in PSQI score with a mean ± SD was from 14.73 ± 4.14 to 10.03 ± 4.04 from baseline to endpoint. However, the EQ5D index score and EQ-visual analogue scale (VAS) at baseline for the control group with a mean ± SD was 0.49 ± 0.30 and 50.17 ± 8.65, respectively, while for the intervention group the values were 0.62 ± 0.26 and 47.17 ± 5.82, respectively. The mean EQ5D index score in the control group improved from 0.49 ± 0.30 to 0.53 ± 0.30, but in the intervention group there was no statistical improvement in mean EQ5D index score from 0.62 ± 0.26 to 0.62 ± 0.27 from baseline to week 8. The EQ 5D improved in both groups and the EQ-VAS score was 2.67 points higher at week 8 as compared to baseline in the control group, while in the intervention group the score was 3.33 points higher at week 8 as compared to baseline. Comparing with baseline, the PSQI scores were significantly reduced after week 4 and week 8 (P = < .001). Furthermore, at the end of the study, the PSQI scores were significantly higher in the control as compared to the intervention group (P = .012).Conclusion:An improvement in sleep quality and quality of life among CKD-aP patients on hemodialysis has been observed in both the control and intervention groups. Zolpidem and acupressure safety profiling showed no severe adverse effect other that drowsiness, nausea and daytime sleeping already reported in literature of zolpidem. 相似文献
49.