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Risks of red blood cell alloimmunization in transfusion‐dependent β‐thalassemia in Oman: a 25‐year experience of a university tertiary care reference center and a literature review 下载免费PDF全文
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Abdelrazeq AS Wilson TR Leitch DL Lund JN Leveson SH 《Diseases of the colon and rectum》2005,48(11):2038-2046
PURPOSE This study aims to determine the incidence, demography, pathologic nature, and clinical significance of ileitis in ulcerative
colitis patients who underwent restorative proctocolectomy.
METHODS A prospectively collected pouch database and the case notes of 100 consecutive patients who underwent restorative proctocolectomy
for ulcerative colitis, under the care of a single surgeon, between 1988 and 2003 were reviewed. The original proctocolectomy
specimens and pouch biopsies were reexamined and regraded blind, using the current diagnostic criteria. Patients were divided
into two groups, those who had ileitis and those who had not. The demographic, clinical, and pathologic characteristics and
the incidence of pouchitis of both groups were compared.
RESULTS Twenty-two patients had ileitis (22 percent). Compared with those with noninflamed ileum, patients with ileitis had a significantly
shorter disease duration (P < 0.005), many of them presented or progressed to a fulminant state requiring acute surgical intervention (P < 0.01), had strong association with pancolitis and primary sclerosing cholangitis (P < 0.001), and had a higher incidence of subsequent development of pouchitis (P < 0.001). There was no correlation between the presence of ileitis and colitis severity.
CONCLUSIONS Ileitis in ulcerative colitis is not rare and does influence the prognosis, and the term “backwash” is a misnomer. Ulcerative
colitis with ileitis represents a distinct disease-specific subset of patients. Its true incidence and clinical significance
can be determined only if detailed microscopic characterization of the terminal ileum is performed routinely in every patient
with ulcerative colitis and the clinical outcome of these patients is audited prospectively.
Presented in part at the meetings of the British Society of Academic and Research Surgery (SARS), Newcastle, United Kingdom,
January 12 to 14, 2005, the American Gastroenterological Association (DDW), New Orleans, Louisiana, May 15 to 20, 2004, and
the Association of Surgeons of Great Britain and Ireland, Harrogate, United Kingdom, April 28 to 30, 2004.
Reprints are not available. 相似文献
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Risk factors for hospital admission among COVID-19 patients with diabetes: A study from Saudi Arabia
Ayman A. Al Hayek Asirvatham A. Robert Abdullah Bin Matar Ali Algarni Haneen Alkubedan Turki Alharbi Afrah Al Amro Seham A. Alrashidi Mohamed Al Dawish 《Saudi medical journal》2020,41(10):1090
Objectives:To elucidate the risk factors for hospital admission among COVID-19 patients with type 2 diabetes mellitus (T2DM).Methods:This retrospective study was conducted at the Prince Sultan Military Medical City, Riyadh, Saudi Arabia between May 2020 and July 2020. Out of 7,260 COVID-19 patients, 920 were identified as T2DM. After the exclusion process, 806 patients with T2DM were included in this analysis. Patients’ data were extracted from electronic medical records. A logistic regression model was performed to estimate the risk factors of hospital admission.Results:Of the total of 806 COVID-19 patients with T2DM, 48% were admitted in the hospital, 52% were placed under home isolation. Older age between 70-79 years (OR [odd ratio] 2.56; p=0.017), ≥80 years (OR 6.48; p=0.001) were significantly more likely to be hospitalized compared to <40 years. Similarly, patients with higher HbA1c level of ≥9% compared to <7%; (OR 1.58; p=0.047); patients with comorbidities such as, hypertension (OR 1.43; p=0.048), cardiovascular disease (OR 1.56; p=0.033), cerebrovascular disease (OR 2.38; p=0.016), chronic pulmonary disease (OR 1.51; p=0.018), malignancy (OR 2.45; p=0.025), chronic kidney disease (CKD) IIIa, IIIb, IV (OR 2.37; p=0.008), CKD V (OR 5.07; p=0.007) were significantly more likely to be hospitalized. Likewise, insulin-treated (OR 1.46; p=0.03) were more likely to require hospital admission compared to non-insulin treated patients.Conclusion:Among COVID-19 patients with diabetes, higher age, high HbA1c level, and presence of other comorbidities were found to be significant risk factors for the hospital admission. 相似文献
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Divyang Patel Kevin M. Trulock Laurie Ann Moennich Erich L. Kiehl Anirudh Kumar Saleem Toro Eoin Donnellan Adam Grimaldi Bryan Baranowski Ayman A. Hussein Khaldoun G. Tarakji Daniel J. Cantillon Mark Niebauer Oussama M. Wazni Niraj Varma Bruce L. Wilkoff John W. Rickard 《Journal of cardiovascular electrophysiology》2020,31(5):1182-1186
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