首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   96篇
  免费   12篇
儿科学   2篇
妇产科学   5篇
基础医学   12篇
口腔科学   6篇
临床医学   10篇
内科学   32篇
皮肤病学   2篇
神经病学   10篇
特种医学   1篇
外科学   11篇
综合类   1篇
一般理论   1篇
预防医学   1篇
眼科学   1篇
药学   2篇
肿瘤学   11篇
  2023年   1篇
  2022年   2篇
  2021年   6篇
  2020年   5篇
  2019年   6篇
  2018年   4篇
  2017年   5篇
  2016年   5篇
  2015年   3篇
  2014年   2篇
  2013年   9篇
  2012年   7篇
  2011年   7篇
  2010年   5篇
  2009年   2篇
  2008年   10篇
  2007年   5篇
  2006年   6篇
  2005年   4篇
  2004年   4篇
  2003年   1篇
  1997年   1篇
  1992年   1篇
  1989年   1篇
  1988年   4篇
  1985年   1篇
  1966年   1篇
排序方式: 共有108条查询结果,搜索用时 15 毫秒
31.
The authors describe a 46-year-old man with isolated splenic vein thrombosis (SVT) that developed after concrete drilling, which caused significant compression and vibration of the abdominal wall. Methyltetrahydrofolate reductase (MTHFR) deficiency-related hyperhomocysteinemia, which was subsequently diagnosed, predisposed him to this event. To the best of the knowledge of authors, this is the first report of isolated splenic vein thrombosis caused by compression and vibration of the abdomen. Relevant aspects of isolated post-traumatic splenic vein thrombosis in this context are discussed.  相似文献   
32.
33.
BackgroundLow heart rate variability (HRV) was found in various medical conditions including heart failure and acute myocardial infarction. Decreased HRV in these conditions predicted poor prognosis.MethodsHRV was estimated in 133 unselected inpatients with relevant clinical bedside conditions by non-linear analysis derived from chaos theory, which calculates the correlation dimension (CD) of the cardiac electrophysiologic system (HRV-CD).ResultsMean HRV-CD in the entire group was 3.75 ± 0.45. Heart failure, coronary artery disease, cardiac arrhythmia, low serum potassium, renal dysfunction, and diabetes mellitus were significantly associated with reduced HRV-CD compared to their counterparts [3.6 vs. 3.9 (P < .001), 3.65 vs. 3.87 (P = .005), 3.58 vs. 3.8 (P = .01), 3.38 vs. 3.81 (P = .02), 3.59 vs. 3.8 (P = .04), and 3.66 vs. 3.82 (P = .04), respectively]. Stepwise logistic regression showed heart failure to be the condition most significantly associated with low HRV-CD (odds ratio 4.2, 95% confidence interval 1.90–9.28, P < .001). In the entire group, decreased HRV-CD (≤ 3.75 vs. > 3.75) was associated with lower survival (P = .01). Mortality of diabetic patients with HRV-CD ≤ 3.75 exceeded the mortality in patients with HRV-CD > 3.75 (P = .02). Heart failure, renal dysfunction or age over 70 combined with HRV-CD ≤ 3.75 also appeared to be associated with augmented mortality.ConclusionsDiminished HRV-CD is associated with heart failure, coronary artery disease, cardiac arrhythmia, renal dysfunction, diabetes mellitus and low serum potassium. Among the latter, heart failure is most significantly associated with decreased HRV-CD. Decreased HRV-CD values, especially in diabetics, are also associated with lower survival.  相似文献   
34.
35.
36.
37.
38.
The biological role of the mitochondrial DNA (mtDNA) control region in mtDNA replication remains unclear. In a worldwide survey of mtDNA variation in the general population, we have identified a novel large control region deletion spanning positions 16154 to 16307 (m.16154_16307del154). The population prevalence of this deletion is low, since it was only observed in 1 out of over 120,000 mtDNA genomes studied. The deletion is present in a nonheteroplasmic state, and was transmitted by a mother to her two sons with no apparent past or present disease conditions. The identification of this large deletion in healthy individuals challenges the current view of the control region as playing a crucial role in the regulation of mtDNA replication, and supports the existence of a more complex system of multiple or epigenetically-determined replication origins.  相似文献   
39.

The risk of coronavirus disease (COVID-19) infection and its complications among patients with atopic dermatitis (AD) treated by dupilumab is yet to be determined. We aimed to assess the risk of SARS-CoV-2 infection, COVID-19-associated hospitalization, and mortality among patients with AD treated by dupilumab. A population-based cohort study was conducted to compare AD patients treated by dupilumab (n?=?238) with those treated by prolonged systemic corticosteroids (≥?3 months; n?=?1,023), phototherapy (n?=?461), and azathioprine or mycophenolate mofetil (MMF; n?=?194) regarding the incidence of COVID-19 and its complications. The incidence rate of COVID-19, COVID-19-associated hospitalization, and mortality among patients treated by dupilumab was 70.1 (95% CI, 40.5–116.4), 5.0 (95% CI, 0.3–24.7), and 0.0 per 1,000 person-year, respectively. The use of dupilumab was not associated with an increased risk of SARS-CoV-2 infection [adjusted HR for dupilumab vs. prolonged systemic corticosteroids: 1.13 (95% CI, 0.61–2.09); dupilumab vs. phototherapy: 0.80 (95% CI, 0.42–1.53); dupilumab vs. azathioprine/MMF: 1.10 (95% CI, 0.45–2.65)]. Dupilumab was associated with a comparable risk of COVID-19-associated hospitalization [adjusted HR for dupilumab vs. prolonged systemic corticosteroids: 0.35 (95% CI, 0.05–2.71); dupilumab vs. phototherapy: 0.43 (95% CI, 0.05–3.98); dupilumab vs. azathioprine/MMF: 0.25 (95% CI, 0.02–2.74)]. When applicable, the risk of mortality was not elevated in patients with AD treated by dupilumab [HR for dupilumab vs. prolonged systemic corticosteroids: 0.04 (95% CI, 0.00–225.20)]. To conclude, dupilumab does not impose an increased risk of SARS-CoV-2 infection or COVID-19 complications in patients with AD. Dupilumab should be continued and considered as a safe drug for moderate-to-severe AD during the pandemic.

  相似文献   
40.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号