全文获取类型
收费全文 | 777篇 |
免费 | 57篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 42篇 |
妇产科学 | 29篇 |
基础医学 | 58篇 |
口腔科学 | 35篇 |
临床医学 | 67篇 |
内科学 | 163篇 |
皮肤病学 | 16篇 |
神经病学 | 76篇 |
特种医学 | 39篇 |
外科学 | 178篇 |
综合类 | 17篇 |
预防医学 | 16篇 |
眼科学 | 18篇 |
药学 | 38篇 |
中国医学 | 1篇 |
肿瘤学 | 22篇 |
出版年
2024年 | 4篇 |
2023年 | 7篇 |
2022年 | 24篇 |
2021年 | 26篇 |
2020年 | 19篇 |
2019年 | 27篇 |
2018年 | 34篇 |
2017年 | 28篇 |
2016年 | 54篇 |
2015年 | 54篇 |
2014年 | 64篇 |
2013年 | 62篇 |
2012年 | 111篇 |
2011年 | 80篇 |
2010年 | 44篇 |
2009年 | 27篇 |
2008年 | 15篇 |
2007年 | 19篇 |
2006年 | 17篇 |
2005年 | 20篇 |
2004年 | 11篇 |
2003年 | 9篇 |
2002年 | 7篇 |
2001年 | 10篇 |
2000年 | 5篇 |
1999年 | 5篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1995年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 4篇 |
1982年 | 1篇 |
1979年 | 2篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1974年 | 5篇 |
1973年 | 3篇 |
1972年 | 5篇 |
1971年 | 1篇 |
1969年 | 4篇 |
1968年 | 2篇 |
1965年 | 3篇 |
1963年 | 2篇 |
排序方式: 共有836条查询结果,搜索用时 15 毫秒
31.
Hilmi Umut Ünal Fatih Tok Emre Adıgüzel Mustafa Gezer İbrahim Aydın Bilge Yılmaz 《Renal failure》2016,38(4):600-604
Objective To investigate the effects of chronic renal failure (CRF) on the distal femoral cartilage thickness by using ultrasonography and to determine the relationship between cartilage thickness and certain disease-related parameters. Design Fifty-seven CRF patients (41 male and 16 female) (mean [SD] age, 44.7 [12.1] years) and 60 healthy controls (41 male and 19 female) (mean [SD] age, 43.5 [13.3] years) were enrolled in this study. Demographic and clinical characteristics were recorded. Cartilage thickness measurements were taken from the medial and lateral condyles, and intercondylar areas of both knees. Results Groups were similar in terms of age, weight, height, body mass index and gender (all p>0.05). The mean cartilage thickness was found to be less in CRF patients than in controls (statistically significant for medial condyles and intercondylar areas both in right and the left knees [all p<0.05]). Cartilage thickness showed no correlation with eGFR, and with the levels of serum urea, creatinine, calcium, magnesium, phosphor, hemoglobin, uric acid and as well as steroid use (all p>0.05) in CRF patients. Conclusion In the light of our findings, we imply that patients with CRF have thinner femoral cartilage than healthy controls. This result may support the view that patients with CRF are at increased risk for developing early knee osteoarthritis. Last but not least, clinicians should be aware of the importance of rehabilitation strategies aimed at decreasing onset and progression of knee osteoarthritis in patients with CRF. 相似文献
32.
33.
34.
Üstüner Mehmet Akif Aksoy Erol Aydın Osman Öter Volkan Bostancı Erdal Birol Akoǧlu Musa 《Hellēnikē cheirourgikē. Acta chirurgica Hellenica》2020,92(2):59-63
Hellenic Journal of Surgery - Hepatolithiasis is the presence of stones within the intrahepatic bile ducts, regardless of common bile duct and gallbladder stones. It is rarely seen in our country... 相似文献
35.
36.
A. Fatih Aydın Jale Çoban Işın Doğan-Ekici Esra Betül-Kalaz Semra Doğru-Abbasoğlu Müjdat Uysal 《Metabolic brain disease》2016,31(2):337-345
D-galactose (GAL) has been used as an animal model for brain aging and antiaging studies. GAL stimulates oxidative stress in several tissues including brain. Carnosine (CAR; β-alanil-L-histidine) and taurine (TAU; 2-aminoethanesulfonic acid) exhibit antioxidant properties. CAR and TAU have anti-aging and neuroprotective effects. We investigated the effect of CAR and TAU supplementations on oxidative stress and brain damage in GAL-treated rats. Rats received GAL (300 mg/kg; s.c.; 5 days per week) alone or together with CAR (250 mg/kg/daily; i.p.; 5 days per week) or TAU (2.5 % w/w; in rat chow) for 2 months. Brain malondialdehyde (MDA), protein carbonyl (PC) and glutathione (GSH) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione transferase (GST) and acetylcholinesterase (AChE) activities were determined. Expressions of B cell lymphoma-2 (Bcl-2), Bax and caspase-3 were also evaluated in the brains by immunohistochemistry. GAL treatment increased brain MDA and PC levels and AChE activities. It decreased significantly brain GSH levels, SOD and GSH-Px but not GST activities. GAL treatment caused histopathological changes and increased apoptosis. CAR and TAU significantly reduced brain AChE activities, MDA and PC levels and elevated GSH levels in GAL-treated rats. CAR, but not TAU, significantly increased low activities of SOD and GSH-Px. Both CAR and TAU diminished apoptosis and ameliorated histopathological findings in the brain of GAL-treated rats. Our results indicate that CAR and TAU may be effective to prevent the development of oxidative stress, apoptosis and histopathological deterioration in the brain of GAL-treated rats. 相似文献
37.
Aydın Ece Erdal Çakmak Ünal Uluca Selvi Kelekçi İlyas Yolbaş Ali Güneş Servet Yel İlhan Tan Velat Şen 《Rheumatology international》2014,34(2):207-212
The aim of this study was to determine the Mediterranean fever (MEFV) gene mutations and their clinical correlations in children with familial Mediterranean fever (FMF) in southeast Turkey. Clinical and laboratory characteristics of 147 (65 males, 82 females) consecutive children with FMF having a positive MEFV gene mutation were prospectively investigated. Patients with negative MEFV gene mutations or atypical FMF presentations and those from other regions of the country were excluded. Clinical manifestations and disease severity scores were recorded. The six most frequent MEFV mutations including M694V, V726A, R726H, P369S, E148Q and P369S were investigated by a reverse hybridization test method. The median age of study group was 9.0 years, median age at diagnosis was 7.8 years, median age at disease onset was 5.0 years, and median follow-up duration was 4.0 years. A positive family history of FMF and parent-to-offspring transmission was found in 58.5 and 42.2 % of families, respectively. The frequencies of independent alleles, with decreasing order, were E148Q (30.7 %), M694V (26.0 %), R761H (13.5 %), V726A (13.0 %), P369S (10.5 %) and M680I (6.3 %) in FMF patients. The M694V subgroup had higher mean disease severity score and longer attack duration compared with E148Q and other mutations subgroups (p < 0.05). Two patients with amyloidosis had the M694V homozygote genotype. In conclusion contrast to other regions and many other ethnicities of the world, the most frequent MEFV gene mutation was E148Q in southeast Turkey. The M694V mutation frequency was lower, and disease severity was relatively mild in FMF children of this region. 相似文献
38.
Aydın Zeliha Uğur Özyürek Taha Keskin Büşra Baran Talat 《Odontology / the Society of the Nippon Dental University》2019,107(1):64-71
Odontology - The aim of the present study was to compare the effect of chitosan nanoparticle, QMix, and 17% EDTA on the penetrability of a calcium silicate-based sealer into dentinal tubules using... 相似文献
39.
Barış Güngör Kazım Serhan Özcan İzzet Erdinler Ahmet Ekmekçi Ahmet Taha Alper Damirbek Osmonov Nazmi Çalık Sukru Akyuz Ercan Toprak Hale Yılmaz Aydın Yıldırım Osman Bolca 《Journal of thrombosis and thrombolysis》2014,37(4):404-410
Red cell distribution width (RDW) and neutrophil/lymphocyte ratio (NLR) have been found to be associated with cardiovascular diseases. Only a few trials have investigated the correlation of these parameters with postoperative atrial fibrillation (AF). However, the correlation of these parameters in non-valvular AF is still unclear. We retrospectively analyzed consecutive AF patients from medical records and included 117 non-valvular AF patients (103 paroxysmal and 14 chronic AF). All subjects underwent physical examination and echocardiographic imaging. Complete blood counts (CBCs) were analyzed for hemoglobin, RDW, neutrophil and lymphocyte counts as well as mean corpuscular volume. Results of CBC tests within the previous year were also included and the averages were used. The demographic and echocardiographic properties of non-valvular AF group were comparable to the control group except for left atrial volumes which were increased in AF (median 33.1, IQR 26.3–41.1 cm3 vs. median 26.4, IQR 24.2–28.9 cm3; p = 0.01). RDW levels were significantly higher in the AF group (median 13.4 %, IQR 12.9–14.1 %) compared to the control (median 12.6 %, IQR 12.0–13.1 %; p = 0.01). NLR was not statistically different in the AF group and the controls (2.04 ± 0.94 vs. 1.93 ± 0.64, respectively; p = 0.32). Hs-CRP levels were higher in the AF group compared to the controls (median 0.84, IQR 0.30–1.43 mg/L vs. median 0.29, IQR 0.18–0.50 mg/L, respectively; p = 0.01). Multivariate logistic regression analysis revealed RDW (OR 4.18, 95 % CI 2.15–8.15; p = 0.01), hs-CRP (OR 3.76, 95 % CI 1.43–9.89; p = 0.01) and left atrial volume (OR 1.31, 95 % CI 1.06–1.21; p = 0.01) as the independent markers of non-valvular AF. Multivariate linear regression analysis revealed that hemoglobin levels (standardized β coefficient = ?0.252; p = 0.01) and the presence of AF (standardized β coefficient = 0.336; p = 0.01) were the independent correlates of RDW levels. Elevated RDW levels, not NLR, may be an independent risk marker for non-valvular AF. 相似文献
40.
Deniz H?zl? Fatih H?zl? Ayd?n K??ü? Saynur Y?lmaz Nermin K??ü? Hacer Halta? Hülya Dede Hasan Kafal? 《Archives of Medical Science》2014,10(2):396-400