全文获取类型
收费全文 | 3826篇 |
免费 | 254篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 135篇 |
妇产科学 | 51篇 |
基础医学 | 561篇 |
口腔科学 | 107篇 |
临床医学 | 237篇 |
内科学 | 941篇 |
皮肤病学 | 101篇 |
神经病学 | 347篇 |
特种医学 | 173篇 |
外科学 | 467篇 |
综合类 | 10篇 |
预防医学 | 139篇 |
眼科学 | 73篇 |
药学 | 291篇 |
中国医学 | 8篇 |
肿瘤学 | 421篇 |
出版年
2023年 | 29篇 |
2022年 | 33篇 |
2021年 | 109篇 |
2020年 | 79篇 |
2019年 | 102篇 |
2018年 | 120篇 |
2017年 | 99篇 |
2016年 | 105篇 |
2015年 | 99篇 |
2014年 | 147篇 |
2013年 | 152篇 |
2012年 | 300篇 |
2011年 | 280篇 |
2010年 | 159篇 |
2009年 | 117篇 |
2008年 | 221篇 |
2007年 | 219篇 |
2006年 | 175篇 |
2005年 | 203篇 |
2004年 | 175篇 |
2003年 | 183篇 |
2002年 | 165篇 |
2001年 | 56篇 |
2000年 | 48篇 |
1999年 | 71篇 |
1998年 | 30篇 |
1997年 | 32篇 |
1996年 | 20篇 |
1995年 | 21篇 |
1994年 | 20篇 |
1993年 | 19篇 |
1992年 | 50篇 |
1991年 | 41篇 |
1990年 | 28篇 |
1989年 | 55篇 |
1988年 | 37篇 |
1987年 | 44篇 |
1986年 | 43篇 |
1985年 | 39篇 |
1984年 | 42篇 |
1983年 | 24篇 |
1982年 | 10篇 |
1981年 | 7篇 |
1980年 | 9篇 |
1979年 | 17篇 |
1978年 | 7篇 |
1977年 | 11篇 |
1976年 | 11篇 |
1972年 | 5篇 |
1966年 | 6篇 |
排序方式: 共有4098条查询结果,搜索用时 31 毫秒
31.
Clinical heterogeneity of neonatal intrahepatic cholestasis caused by citrin deficiency: case reports from 16 patients 总被引:5,自引:0,他引:5
Tazawa Y Kobayashi K Abukawa D Nagata I Maisawa S Sumazaki R Iizuka T Hosoda Y Okamoto M Murakami J Kaji S Tabata A Lu YB Sakamoto O Matsui A Kanzaki S Takada G Saheki T Iinuma K Ohura T 《Molecular genetics and metabolism》2004,83(3):213-219
A deficiency of citrin, which is encoded by the SLC25A13 gene, causes both adult-onset type II citrullinemia (CTLN2) and neonatal intrahepatic cholestasis (NICCD). We analyzed 16 patients with NICCD to clarify the clinical features of the disease. Severe intrahepatic cholestasis with fatty liver was the most common symptom, but the accompanying clinical features were variable, namely; suspected cases of neonatal hepatitis or biliary atresia, positive results from newborn screening, tyrosinemia, failure to thrive, hemolytic anemia, bleeding tendencies and ketotic hypoglycemia. Laboratory data showed elevated serum bile acid levels, hypoproteinemia, low levels of vitamin K-dependent coagulation factors, and hypergalactosemia. Hypercitrullinemia was detected in 11 out of 15 patients examined. Most of the patients were given a lactose-free and/or medium chain triglycerides-enriched formula and lipid-soluble vitamins. The prognosis of the 16 patients is going fairy well at present, but we should observe these patients carefully to see if they manifest any symptom of CTLN2 in the future. 相似文献
32.
K. Joh S. Aizawa K. Ohkawa T. Morioka T. Oite F. Shimizu S. Batsford A. Vogt 《Virchows Archiv : an international journal of pathology》1994,424(6):587-591
We developed an experimental protocol for planting exogenous antigens with different molecular weights and charges on the constituents of the renal tubulointerstitium. The cationized antigens were injected selectively into the left renal arteries of Wistar rats. Antigen localization was documented by immunohistochemistry on frozen sections. Cationized bovine serum albumin (BSA; 68 kDa, isoelectric point =9.5) localized almost exclusively along the glomerular capillary wall. After application of highly cationic polyethyleneimine, cationized BSA given subsequently was found in a linear distribution along the glomerular capillary wall and along the peritubular capillaries. The fate of highly cationized ovalbumin conjugated with trinitrophenol (TNP-OA), subjected to gel filtration to obtain monomers (42 kDa, isoelectric point >10) differed; it was deposited in a linear pattern on the tubular basement membrane (TBM) and Bowman's capsule, and remained up to 36 h after injection. Noncationized, monomeric TNP-OA (42 kDa, isolectnic point =4.6) showed fine granular deposition in the tubular epithelium exclusively. These findings indicate that the barrier of the glomerular BM acts selectively on antigens with different molecular weights. They either settle on the peritubular capillaries, after passing the glomerular, or reach the urinary space, after which they are reabsorbed by the tubular epithelial cells to reach the TBM. 相似文献
33.
34.
Amagai T Mouri T Kirii K Hori T Kaneko M Ohkawa H 《Clinical and experimental pharmacology & physiology. Supplement》2002,(29):S19-S22
1. Biliary atresia (BA), as a common disease in Japan, and cystic fibrosis (CF), as an extremely uncommon disease in Japan, were selected to assess the clinical significance of measurement of energy expenditure (EE). 2. Energy expenditure was significantly higher in children with BA than in normal children. 3. Measurement of EE in BA lead to clues to resolving its mechanism by novel assessment of interleukin-6 and leptin. 4. Energy expenditure in children with CF is also higher, but this has been addressed by nutritional intervention with additional calories. 5. Individualization of EE measurement is necessary in the analysis of pathological mechanisms and nutritional management of patients with both common and uncommon diseases. 相似文献
35.
36.
37.
38.
39.
Saheki T Kobayashi K Iijima M Horiuchi M Begum L Jalil MA Li MX Lu YB Ushikai M Tabata A Moriyama M Hsiao KJ Yang Y 《Molecular genetics and metabolism》2004,81(Z1):S20-S26
Citrin is a mitochondrial aspartate glutamate carrier primarily expressed in the liver, heart, and kidney. We found that adult-onset type II citrullinemia is caused by mutations in the SLC25A13 gene that encodes for citrin. In this report, we describe the frequency of SLC25A13 mutations, the roles of citrin as a member of the urea cycle and as a member of the malate-aspartate shuttle, the relationship between its functions and symptoms of citrin deficiency, and therapeutic issues. 相似文献
40.
Functions of neurons in enteric plexuses of cat intestine 总被引:4,自引:0,他引:4