Fast FFT-based bioheat transfer equation computation

This paper describes a modeling method of the tissue temperature evolution over time in hyper or hypothermia. The tissue temperature evolution over time is classically described by Pennes’ bioheat transfer equation which is generally solved by a finite difference method. In this paper we will present a method where the bioheat transfer equation can be algebraically solved after a Fourier transformation over the space coordinates. As an example, we implemented this method for the simulation of a percutaneous high intensity ultrasound hepatocellular carcinoma curative treatment and compared it with the finite difference method and experimental data.     

绝经后阴道出血400例分析

目的明确引起绝经后阴道出血的病因及诊断方法.方法对400例绝经后阴道出血患者进行临床及病理分析.结果400例中恶性肿瘤78例,占19.5%,其中宫颈癌34例,占恶性肿瘤的43.59%;子宫内膜癌28例,占35.90%;卵巢癌16例,占20.51%;检出良性病变322例,占80.5%;患者年龄越大(＞58岁),绝经时间越长(＞10 a),恶性肿瘤的发生率越高.结论对绝经后阴道出血患者的诊断应注重常规的妇科检查和必要的辅助检查以明确病因,做到早诊早治,可预防和减少恶性肿瘤的发生.     

黔岭淫羊藿化学成分的研究Ⅰ

 目的:对黔岭淫羊藿(Epimedium leptorrhizumStearm.)的化学成分进行分离,并鉴定其化学结构?方法:采用柱层析方法进行分离,用UV,IR,MS,¹H-NMR和¹³C-NMR等光谱技术鉴定化合物的结构?结果:从醋酸乙酯部分分离到4个化合物,经鉴定为:thalictoside(Ⅰ),2″-鼠李糖基淫-羊藿次苷Ⅱ[2″-O-rhamnosyl-icarisidⅡ(Ⅱ)],箭藿苷A[sagitatosideA(Ⅲ)],大花淫羊藿苷B[ikarisosideB(Ⅳ)]?结论:化合物Ⅰ为苯酚苷类化合物,化合物Ⅱ,Ⅲ,Ⅳ为8-异戊烯基黄酮苷类化合物,4个化合物均为首次从该植物中分离得到?     

高效液相色谱法测定血浆中泮托拉唑浓度

 目的:建立用高效液相色谱法测定血浆中泮托拉唑浓度的方法,为进行泮托拉唑的体内药物代谢、生物利用度研究提供基础?方法:血浆用0.01mol·L^-1磷酸氢二钠做pH调节剂,二氯甲烷做提取溶剂,硝西泮作内标?采用Platinum C₁₈(5u,250mm×4.6mm)柱,流动相:甲醇-水-醋酸盐缓冲液(40∶60∶5),流速1.0ml·min^-1,检测波长286nm?结果:该法回收率平均在98.36%～104.27%,重现性高,RSD在4.693%～9.12%范围内(n=5),线性范围:20～4000μg·L^-1,最低检测浓度15μg·L^-1?结论:HPLC测定血浆中泮托拉唑的方法简便、准确、灵敏、专一,能满足血药浓度测定及药代动力学研究的需要?     

注射用氟罗沙星的合成工艺改进

 目的:对氟罗沙星的合成工艺进行了改进以提高其收率?方法:主要对反应物配比、反应时间、催化剂用量等因素进行了优化?结果:氟乙基化单步收率提高了14%,总收率提高了6%?结论:本反应路线克服了国内外已有路线原料供应不足,价格昂贵,收率偏低的缺点,降低了生产成本?经测定符合注射用氟罗沙星的质量标准,产品收率提高明显?     

New developmental stages for common marmosets (Callithrix jacchus) using mass and age variables obtained by K-means algorithm and self-organizing maps (SOM)

This study proposes new developmental stages for Callithrix jacchus, using K-Means algorithm and an artificial neural network-self-organising maps (SOM) as computational tools, based on weight and age. Eight developmental stages are proposed: Infant I, II and III, Juvenile I and II, Sub adult, Young adult and Older adult. This classification is consistent with the first appearance of several behavioural and physiological characteristics and thus may have generality in defining critical developmental periods. It also reveals differences in male and female development and establishes a stage for the onset of the final adult life cycle. This classification is also important to understanding the biology of the ontogenetic development of common marmosets, providing new insights for the management and care of captive animals and improving age estimate indicators when specimens are captured in long term monitoring of free ranging groups.