全文获取类型
收费全文 | 399997篇 |
免费 | 12433篇 |
国内免费 | 400篇 |
专业分类
耳鼻咽喉 | 4111篇 |
儿科学 | 13735篇 |
妇产科学 | 7609篇 |
基础医学 | 48996篇 |
口腔科学 | 6760篇 |
临床医学 | 30071篇 |
内科学 | 81066篇 |
皮肤病学 | 6824篇 |
神经病学 | 36471篇 |
特种医学 | 15494篇 |
外国民族医学 | 101篇 |
外科学 | 56576篇 |
综合类 | 3282篇 |
一般理论 | 62篇 |
预防医学 | 38309篇 |
眼科学 | 7209篇 |
药学 | 25367篇 |
中国医学 | 1329篇 |
肿瘤学 | 29458篇 |
出版年
2023年 | 1240篇 |
2022年 | 896篇 |
2021年 | 3504篇 |
2020年 | 2079篇 |
2019年 | 3915篇 |
2018年 | 28319篇 |
2017年 | 21307篇 |
2016年 | 23424篇 |
2015年 | 6274篇 |
2014年 | 6425篇 |
2013年 | 9878篇 |
2012年 | 22571篇 |
2011年 | 35941篇 |
2010年 | 25895篇 |
2009年 | 16947篇 |
2008年 | 32252篇 |
2007年 | 35336篇 |
2006年 | 13949篇 |
2005年 | 15410篇 |
2004年 | 15775篇 |
2003年 | 15606篇 |
2002年 | 13143篇 |
2001年 | 6378篇 |
2000年 | 6605篇 |
1999年 | 5666篇 |
1998年 | 1072篇 |
1997年 | 925篇 |
1996年 | 780篇 |
1995年 | 726篇 |
1992年 | 3229篇 |
1991年 | 2954篇 |
1990年 | 2852篇 |
1989年 | 2571篇 |
1988年 | 2420篇 |
1987年 | 2232篇 |
1986年 | 2109篇 |
1985年 | 1909篇 |
1984年 | 1416篇 |
1983年 | 1208篇 |
1979年 | 1215篇 |
1978年 | 858篇 |
1977年 | 801篇 |
1975年 | 805篇 |
1974年 | 1005篇 |
1973年 | 997篇 |
1972年 | 941篇 |
1971年 | 927篇 |
1970年 | 880篇 |
1969年 | 927篇 |
1968年 | 804篇 |
排序方式: 共有10000条查询结果,搜索用时 62 毫秒
141.
142.
143.
Victor Aboyans Louis Labrousse Philippe Lacroix Jér?me Guilloux Seifeddine Sekkal Alexandre Le Guyader Elisabeth Cornu Marc Laskar 《European journal of cardio-thoracic surgery》2006,30(2):300-304
BACKGROUND: Despite major improvement in surgical techniques and intensive care management, stroke remains one of the most devastating complications of coronary artery bypass grafting (CABG). We aimed to determine factors predicting the occurrence of stroke during CABG. A special interest was focused on preoperative therapies. METHODS: We prospectively enrolled 810 consecutive candidates for CABG alone in a specific database, including all pre- and perioperative data (history, clinical, therapeutic, cardiac catheterization, surgical and intensive care data). Univariate tests and then multiple logistic regression analysis were used to determine independent predictive factors. RESULTS: During the first postoperative month, stroke occurred in 11 cases and transient ischemic attack (TIA) in 4 additive cases (cumulative rate: 1.85%). After the multivariate analysis, the following factors remained significant (p<0.05) in the predictive model, with corresponding odds ratios between brackets: redo cardiac surgery (7.45), unstable cardiac status (4.74), past history of cerebrovascular disease (4.14), past history of peripheral arterial disease (3.55), whereas the presence of preoperative statins was protective (0.24, 95% IC: 0.07-0.78). The addition of perioperative data (aortic calcification, postoperative arrhythmia, on/off-pump surgery) did not change the final predictive model. CONCLUSION: To our knowledge, this is the first real-world observational report highlighting the interest of statins for the prevention of stroke in the very special situation of CABG. Even though according to randomized trials coronary patients have a benefit from these drugs, a special level of interest should be directed towards those presenting the above-mentioned risk factors. 相似文献
144.
145.
146.
Nephronophthisis related to homozygous NPHP1 gene deletion as a cause of chronic renal failure in adults. 总被引:1,自引:0,他引:1
147.
148.
Luis Gajate Ascensión Martín Elena Elías Maria T Tenorio Angélica de Pablo Cristina Carrasco Adolfo Martínez Angel Candela Javier Zamora Fernando Lia?o 《Liver transplantation》2006,12(9):1371-1380
Although renal dysfunction is common after liver transplantation, postoperative renal function after split liver transplantation (SLT) has not been well studied. Renal function immediately after surgery was analyzed retrospectively in 16 patients that received a SLT (SLT group). The results were compared with corresponding data from 31 matched patients that received a full-size liver transplant (FSLT group) during the same period. Serum creatinine (SCr) was measured before surgery, and, after transplantation, daily during the first week and at days 14, 21, and 28. Renal dysfunction (RD) was defined as the requirement for renal replacement therapy (RRT) or a 100% increase in SCr if the basal value had been <1.0 mg/dL or a 50% increase in SCr if the basal value had been >1.0 mg/dL. SCr had to be at least 1.5 mg/dL for a diagnosis of RD to be considered. The classification of RD was: mild, SCr 1.5-2.4 mg/dL; moderate, SCr 2.5-4.0 mg/dL; or severe, SCr >4.0 mg/dL (the requirement for RRT). Both donor and recipient age and cold ischemia time were lower in the SLT group than in the FSLT group (P < 0.05). Length of surgery was longer in the SLT group (P < 0.05). There were no significant differences between groups with respect to Model for End-Stage Liver Disease scores, the need for transfusions, the length of admission to the intensive care unit (ICU), survival rate, individual severity index, or sepsis-related organ failure assessment scores at the time of diagnosing RD. Immunosuppression regimens were similar in both groups. RD developed in 82% of SLT patients, but in only 58% of FSLT patients (P = not significant [NS]). Among SLT patients, RD (23.0% mild, 15.5% moderate, and 61.5% severe) was more severe (P = 0.007) than in FSLT patients (63.1% mild, 15.8% moderate, and 24.1% severe). The requirement for RRT in the SLT group (43.7%) was significantly greater (P < 0.05) than that in the FSLT group (12.9%). This finding may be due to the different incidence of sepsis in the 2 groups (SLT 37.5% vs. FSLT 9.7%; P < 0.05). In conclusion, although the number of patients studied was small, our data suggest a higher incidence of RD and a greater requirement for RRT in patients that receive a split liver graft than in those that receive a full size liver graft. 相似文献
149.
Jean-Sébastien Fallu Jürgen Rehm Emmanuel N. Kuntsche Esther Grichting Neerav Monga Edward M. Adlaf Susan J Bondy Gerhard Gmel 《Sozial- und Pr?ventivmedizin》2006,8(1):363-372
Volume and profile of alcohol consumption among students and classmates as predictors of aggression and victimization: a multilevel
analysis among Swiss adolescents
Objective:
To test the effects of the volume of alcohol consumption and drinking patterns on alcohol-related aggression and victimization, both at the individual and class levels. 相似文献150.
Jér?me Dumortier Marie-Claude Gagnieu Janine Salandre Olivier Guillaud Philipe Guillem Mustapha Adham Olivier Boillot 《Liver transplantation》2006,12(9):1342-1346
Gastrointestinal (GI) disorders are one of the main adverse events in patients treated by mycophenolic acid (MPA). The aim of this prospective study was to evaluate the effect of conversion from mycophenolate mofetil (MMF) to enteric-coated mycophenolate sodium (EC-MPS) in liver transplant patients presenting GI side-effects Since January 2003, stable liver transplant patients receiving MMF and presenting GI disorders, without evidence of other origin than MMF were enrolled. Conversion was performed without a washout period at an equimolar daily dosage. Thirty-six patients were included after a median delay of 45 months after liver transplantation (LT) (16 women and 20 men, median age of 47 years). Diarrhoea was the main clinical symptom (n = 28, 77.7%). At the time of inclusion, patients were treated with MMF since 18 months (range 3-28) and GI disorders were known for 9 months (range 3-12). After a median follow-up of 12 months after conversion, GI disorders were resolved in 20 patients (55%), improved in 6 patients (17%) and not modified or worsened in 10 patients (28%). Our results strongly suggest that conversion from MMF to EC-MPS in liver transplant patients can improve gastrointestinal disorders in a majority of the patients, and therefore might be considered as the best therapeutic option. 相似文献