全文获取类型
收费全文 | 262篇 |
免费 | 12篇 |
国内免费 | 46篇 |
专业分类
儿科学 | 8篇 |
妇产科学 | 9篇 |
基础医学 | 34篇 |
口腔科学 | 1篇 |
临床医学 | 47篇 |
内科学 | 56篇 |
皮肤病学 | 4篇 |
神经病学 | 2篇 |
特种医学 | 46篇 |
外科学 | 35篇 |
综合类 | 17篇 |
预防医学 | 5篇 |
眼科学 | 5篇 |
药学 | 29篇 |
肿瘤学 | 22篇 |
出版年
2022年 | 4篇 |
2021年 | 3篇 |
2020年 | 1篇 |
2019年 | 3篇 |
2018年 | 1篇 |
2017年 | 3篇 |
2016年 | 4篇 |
2015年 | 5篇 |
2014年 | 8篇 |
2013年 | 13篇 |
2012年 | 10篇 |
2011年 | 5篇 |
2010年 | 11篇 |
2009年 | 19篇 |
2008年 | 11篇 |
2007年 | 31篇 |
2006年 | 12篇 |
2005年 | 18篇 |
2004年 | 13篇 |
2003年 | 7篇 |
2002年 | 5篇 |
2001年 | 8篇 |
2000年 | 3篇 |
1999年 | 6篇 |
1998年 | 14篇 |
1997年 | 18篇 |
1996年 | 5篇 |
1995年 | 11篇 |
1994年 | 6篇 |
1993年 | 6篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 5篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 5篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1976年 | 6篇 |
1975年 | 3篇 |
排序方式: 共有320条查询结果,搜索用时 15 毫秒
101.
Campbell JK; Houser OW; Stevens JC; Wahner HW; Baker HL Jr; Folger WN 《Radiology》1978,126(3):695-702
One hundred forty-one patients with cerebral or cerebellar infarction were examined by computed tomography (CT) as soon after the ictus as possible. The examination was repeated in 7 days, and a radionuclide brain scan was performed. The overall detection rate for ischemic infarction was approximately equal for both techniques, ranging from 58% for radionuclide scanning to 66% for the delayed CT. Almost half of the supratentorial infarcts examined by CT on the day of the ictus were demonstrated. Mass effect was observed as early as the first day and as late as the 25th day. 相似文献
102.
103.
104.
105.
106.
Recent advances and future directions in targeting the secretory apparatus in multiple myeloma 下载免费PDF全文
Multiple myeloma is a genetically heterogeneous tumour of transformed plasma cells, terminally differentiated effectors of the B cell lineage specialized in producing large amounts of immunoglobulins. The uniquely well‐developed secretory apparatus that equips normal and transformed plasma cells with the capacity for high‐level protein secretion constitutes a distinctive therapeutic target. In this review we discuss how fundamental cellular processes, such as the unfolded protein response (UPR), endoplasmic reticulum (ER)‐associated degradation and autophagy, maintain intracellular protein homeostasis (proteostasis) and regulate plasma cell ontogeny and malignancy. We summarize our current understanding of the cellular effects of proteasome inhibitors and the molecular bases of resistance to them. Furthermore, we discuss how improvements in our understanding of the secretory apparatus and of the complex interactions between intracellular protein synthesis and degradation pathways can disclose novel drug targets for multiple myeloma, defining a paradigm of general interest for cancer biology and disorders of altered proteostasis. 相似文献
107.
活体生物萤光成像技术(in vivo biolumines- cence imaging)是近年来发展起来的一项崭新的分子、基因表达的分析检测系统.与传统的检测方法相比具有巨大的优越性,堪称是分子基因检测领域的革命性技术.随着萤光成像设备的进一步完善以及转基因动物的构建开发,在欧美等发达国家活体生物萤光成像技术已被广泛地应用于感染、肿瘤免疫及治疗、自身免疫性疾病、器官移植、基因治疗、药物开发等实验领域.本文就活体生物萤光成像技术的发展和应用作如下综述. 相似文献
108.
With sequential investigation of immunological and cytochemical markers on single cells, T lymphocyte subsets defined by monoclonal antibodies were examined in the peripheral blood of healthy adults. Leu-3a+ T cells (helper/inducer) were 80.0 +/- 6.6% dot positive with unspecific acid alpha-naphthyl acetate esterase (ANAE) and 52.2 +/- 15.8% dot positive with diaminopeptidase IV (DAP IV) staining, as compared to 52.6 +/- 7.6% ANAE and 29.1 +/- 10.9% DAP IV dot positivity in Leu-2a+ T cells (suppressor/cytotoxic). Although these differences were significant (P less than 0.001 and P = 0.002, respectively), the rather high % of dot positivity in Leu-2a+ cells precludes ANAE or DAP IV staining as a simple method for the determination of T lymphocyte subsets. In acid phosphatase staining, no significant difference in focal positivity between Leu3a+ and Leu-2a+ T cell subpopulations was detected (63.3 +/- 10.9% and 52.3 +/- 10.0%, respectively; P greater than 0.1). 相似文献
109.
Patrick?HW?Chu Yiu-fai?Ng Chi-ho?To Kwok-fai?So Brian?Brown Henry?HL?ChanEmail author 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2012,250(2):261-270
Purpose
To investigate the association of the luminance-modulation global flash multifocal electroretinogram (mfERG) and other clinical assessments of vision in subsets of subjects at high risk of developing glaucomatous damage. 相似文献110.