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991.
Noritoshi Kobayashi Tetsu Niwa Hiroyuki Kirikoshi Koji Fujita Masato Yoneda Satoru Saito Atsushi Nakajima 《Hepatology research》2010,40(6):585-593
Aim: Congenital extrahepatic portosystemic shunt (CEPS) is a rare anomaly in which the enteric blood bypasses the liver and drains into the systemic veins through various venous shunts. Patients with CEPS often have liver tumors and complications such as cardiac or other anomalies, but portosystemic encephalopathy and gastrointestinal bleeding occur only occasionally. The clinical problems differ for each individual with CEPS, and establishing a prognosis can be very difficult. Methods: We reviewed the clinical features of 136 reported cases of CEPS and classified these cases according to their portosystemic shunts. Results: We classified portal blood flow directly into the inferior vena cava (IVC) as type A (88 cases), portal blood flow into the renal vein as type B (36 cases), and portal blood flow into the iliac vein via an inferior mesenteric vein as type C (12 cases). Type A patients were complicated with cardiac anomalies at a higher rate than other types. Type C patients had lower prevalences of cardiac anomalies and portosystemic encephalopathy than the other types, but the prevalence of gastrointestinal bleeding was significantly higher (P < 0.0001). The prognosis of CEPS has improved, and only six deaths have been previously reported, all of which occurred in type A patients. Conclusions: We reviewed the previously reported cases of CEPS. Classification according to the portosystemic shunt system might be useful for investigating the clinical features of CEPS. 相似文献
992.
Tomomitsu Tahara Tomoyuki Shibata Masakatsu Nakamura Hiromi Yamashita Daisuke Yoshioka Masaaki Okubo Naoko Maruyama Toshiaki Kamano Yoshio Kamiya Hiroshi Fujita Yoshihito Nakagawa Mitsuo Nagasaka Masami Iwata Kazuya Takahama Makoto Watanabe Hiroshi Nakano Ichiro Hirata Tomiyasu Arisawa 《Clinical and experimental medicine》2009,9(2):125-130
Tryptase acting at protease-activated receptor 2 (PAR2) contributes to the pathogenesis of Inflammatory bowel diseases (IBDs).
DNA methylation has been shown to be an important mechanism in gene silencing. We attempted to clarify the relationship between
the promoter methylation of PAR2 and ulcerative colitis (UC). 84 UC patients enrolled in the study. UC patients were classified
by disease behavior, severity and extent of disease. For rectal inflammatory mucosal specimens from all the patients, and
normal terminal ileum from 23 patients, promoter methylation of PAR2 gene was quantified by digital densitographic analysis
following to methylation-specific polymerase chain reaction (MSP). The mean methylation levels of the PAR2 gene in all 84
subjects was 38.4 ± 19.6%. Although mean methylation levels in rectal inflammatory mucosa, and paired normal terminal ileum
did not vary, methylation levels of PAR2 gene was significantly higher in total colitis than rectal colitis (total colitis
vs. rectal colitis; 42.9 ± 19.6% vs. 34.5 ± 18.9%, P = 0.046). The higher methylation levels were also associated with Steroid-dependent (P = 0.002) and refractory (P = 0.007) UC. Our data suggest that PAR2 methylation status in rectal mucosa correlates with more severe disease phenotypes
of UC. 相似文献
993.
Masakatsu Nakamura Tomoyuki Shibata Tomomitsu Tahara Daisuke Yoshioka Masaaki Okubo Joh Yonemura Tomiyasu Arisawa Ichiro Hirata 《Gastric cancer》2011,14(4):378-384
Background
Early gastric cancer located from the pyloric ring to inside the duodenal bulb (DB) is not easily treated by endoscopic submucosal dissection (ESD). The endoscope needs to be reversed inside the DB to set the resection line at a safe distance from the anal side. Because of the space limitations and limited flexibility of conventional endoscopy (CE), there have been increasing possibilities of complications. Here we report a new ESD technique using a transnasal endoscope (TN-E) that is reversed inside the DB. 相似文献994.
Hiroki Endo Kunihiro Hosono Takuma Higurashi Eiji Sakai Hiroshi Iida Yasunari Sakamoto Koji Fujita Hirokazu Takahashi Tomoko Koide Masato Yoneda Chikako Tokoro Masahiko Inamori Yasunobu Abe Nobuyuki Matsuhashi Atsushi Nakajima 《Digestive endoscopy》2011,23(1):56-61
Aim: The major limitation of capsule endoscopy (CE) has been the lack of a standardized and validated severity scale for mucosal injury. The aim of the present study was to verify the usefulness of quantifying small bowel mucosal changes associated with giving low‐dose aspirin (LDA) using a CE scoring index. Methods: The CE score for small bowel mucosal injury was investigated to evaluate the severity of mucosal injury. Healthy volunteers and patients suspected of having small bowel disease were recruited for this study. The short‐term LDA group (V + S‐LDA group) consisted of volunteers who took low‐dose aspirin for 14 days; this group was then compared with healthy volunteers who did not receive LDA treatment (V‐Control group). The long‐term LDA group (L‐LDA group) consisted of patients with at least a 3‐month history of daily LDA use; this group was compared with non‐users of LDA (P‐Control group). Results: The CE score was significantly higher in the V + S‐LDA group than in the V‐Control group. In the V‐Control group, almost all the subjects were categorized as exhibiting a ‘normal’ change. ‘Mild’ changes were observed significantly more frequently in the V + S‐LDA group than in the V‐Control group. The CE score was significantly higher in the L‐LDA group than in the P‐Control group. ‘Mild’ or ‘moderate or severe’ changes were observed significantly more frequently in the L‐LDA group than in the P‐Control group. Conclusion: The CE scoring system was useful for evaluating LDA‐associated small bowel mucosal disease activity and for objectively scoring the small bowel inflammatory disease state. 相似文献
995.
Takeru Wakatsuki Katsutoshi Obara Atsushi Irisawa Hiroaki Sakamoto Toshimitu Kuwana Fujio Takiguchi Ayako Saito Hideo Shishido Takuto Hikichi Hitoshi Oyama Goro Shibukawa Tadayuki Takagi Go Yamamoto Hidemichi Imamura Yuta Takahashi Ai Sato Masaki Sato Reiji Kasukawa Hiromasa Ohira 《Digestive endoscopy》2009,21(4):232-238
Background: The prognostic factors, including gastric variceal bleeding itself, in patients with gastric varices (GV) after endoscopic treatment remain unclear. The aim of this study was to analyze prognostic factors in patients with GV after endoscopic treatment as well as to evaluate safety and efficacy of our endoscopic treatment. Patients and Methods: This study enrolled 115 patients who underwent endoscopic treatment for GV between October 1988 and December 2003 using cyanoacrylate and 5% ethanolamine oleate. Successful hemostasis, recurrence rates, rebleeding rates, survival rates, complications and prognostic factors after the treatment were retrospectively reviewed. Results: Treatment sessions for GV were performed 3.4 ± 2.5 times. All cases, including 14 emergency cases, were treated successfully. The cumulative recurrence rates at 1, 3 and 5 years after the treatment were 7.0%, 15.6% and 20.0%, respectively, and the cumulative rebleeding rates at 1, 3 and 5 years were 3.5%, 8.7% and 14.8%, respectively. The overall survival rates were 78.3%, 63.7% and 51.5% at 1, 3 and 5 years, respectively. Grade B or C in Child–Pugh classification, emergency or elective cases, and association with hepatocellular carcinoma were identified as significant negative prognostic factors after endoscopic treatment by multivariate analysis. Although several complications were observed, there was no mortality. Conclusions: Grade B or C in Child–Pugh classification, emergency or elective situation, and association with hepatocellular carcinoma are negative prognostic factors after endoscopic treatment. 相似文献
996.
Misaki Fujii Daisuke Suzuki Eiichi Uchiyama Takayuki Muraki Atsushi Teramoto Mitsuhiro Aoki Shigenori Miyamoto 《Manual therapy》2010,15(1):117-121
Limitation of ankle motion is in many cases treated by joint mobilization (JM), a kind of manual physical therapy technique. Until now, the JM approach has mainly focused on the talocrural joint, with less attention to the distal tibiofibular joint. We applied cyclic loading to the lateral malleolus as in JM in order to clarify the relationship between the dorsiflexion angle and the excursion of the lateral malleolus. Seven normal, fresh-frozen cadaver legs were used. To each specimen, cyclic loading with a 30 N force was applied 1000 times to the lateral malleolus at a speed of 15 N/s. The displacement of the lateral malleolus was measured with a magnetic tracking system. The maximum dorsiflexion angle was measured before and after cyclic loading. After the first 100 and 1000 times of cyclic loading, the tibia was displaced 0.44 ± 0.30 mm and 0.75 ± 0.36 mm, respectively, and the fibula was displaced 0.44 ± 0.28 mm and 0.92 ± 0.39 mm, respectively. The average dorsiflexion angle increased from 14.36 ± 7.51° to 16.74 ± 7.21° after cyclic loading (P < 0.05). Movement of the distal tibiofibular joint led to a significant increase in the range of ankle dorsiflexion. These results suggest that tibiofibular JM would be effective for limitation of ankle dorsiflexion. 相似文献
997.
Identification of a novel tobacco DnaJ-like protein that interacts with the movement protein of tobacco mosaic virus 总被引:2,自引:0,他引:2
Takumi Shimizu Atsushi Yoshii Keitaro Sakurai Koji Hamada Yasuyuki Yamaji Masashi Suzuki Shigetou Namba Tadaaki Hibi 《Archives of virology》2009,154(6):959-967
The movement protein (MP) of tobacco mosaic virus (TMV) mediates the transport of viral RNA from infected cells to neighboring
uninfected cells via plasmodesmata by interacting with putative host factors. To find such host factors, we screened tobacco
proteins using the yeast two-hybrid system. NtMPIP1, a novel subset of DnaJ-like proteins, was identified from a tobacco cDNA
library, and its specific interaction with TMV MP was confirmed with an in vitro filter-binding assay. In a deletion analysis,
using a series of truncated TMV MPs and NtMPIP1s, at least two regions of TMV MP, amino acid residues 65–86 and 120–185, conferred
the ability to interact with the C-terminal domain of NtMPIP1, which is thought to be involved in substrate binding. Virus-induced
gene silencing of NtMPIP1 significantly inhibited the spread of TMV. Therefore, it is reasonable to consider that endogenous NtMPIP1 is a host factor
involved in virus cell-to-cell spread by interacting with TMV MP.
Nucleotide sequence data reported are available in the DDBJ/EMBL/GenBank databases under accession number AB092334. 相似文献
998.
Takashi Tanimoto MD Toshio Imanishi MD PhD Atsushi Tanaka MD PhD Takashi Yamano MD Hironori Kitabata MD Shigeho Takarada MD PhD Takashi Kubo MD PhD Kazushi Takemoto MT Nobuo Nakamura MD Kumiko Hirata MD PhD Masato Mizukoshi MD PhD Takashi Akasaka MD PhD 《Journal of the American Society of Echocardiography》2009,22(9):1015-1021
999.
1000.
Tatsuki Yoshimatsu Daisuke Yoshida Hiroyuki Shimada Taiki Komatsu Atsushi Harada Takao Suzuki 《Geriatrics & Gerontology International》2013,13(2):351-357
Aim: Near‐infrared spectroscopy (NIRS) allows estimation of the percentage of body fat (%BF) regardless of the patient's posture; thus, it is useful for assessment of elderly patients with severe decline of basic activity who cannot hold a standing position. However, the accuracy by which the near‐infrared light emitted from NIRS reflects subcutaneous tissue is unknown. The aim of this study was to assess how correctly NIRS reflects the subcutaneous fat and muscle thickness derived from ultrasonography in community‐dwelling elderly. Methods: A total of 93 community‐dwelling older adults aged 65 years and older were enrolled in this study (mean 75.8 years, 6.7 SD). Participants were assessed according to optical density (OD) measurements by NIRS, subcutaneous fat and muscle thickness by ultrasonography, and muscle strength. Pearson's correlation coefficients were calculated for each sex. Stepwise multiple regression analysis was used to identify factors that contributed to OD for each sex. Results: OD measured at the forearm and thigh were significantly correlated with subcutaneous fat thickness. In stepwise multiple regression analyses, subcutaneous fat thickness was found to be a significant determinant of OD in men (forearm β = −0.37, P = 0.01; thigh β = −0.63, P < 0.001) and women (forearm β = −0.50, P < 0.001; thigh: β = −0.52, P < 0.001). Conclusions: These results suggest that NIRS can appropriately estimate fat‐free mass. By adding other variables to OD as the predictive variable, skeletal muscle mass might be estimated in the elderly population. Geriatr Gerontol Int 2013; 13: 351–357 . 相似文献