全文获取类型
收费全文 | 17964篇 |
免费 | 895篇 |
国内免费 | 188篇 |
专业分类
耳鼻咽喉 | 133篇 |
儿科学 | 329篇 |
妇产科学 | 157篇 |
基础医学 | 2039篇 |
口腔科学 | 363篇 |
临床医学 | 1072篇 |
内科学 | 5605篇 |
皮肤病学 | 387篇 |
神经病学 | 1082篇 |
特种医学 | 819篇 |
外科学 | 2962篇 |
综合类 | 76篇 |
一般理论 | 3篇 |
预防医学 | 402篇 |
眼科学 | 433篇 |
药学 | 1044篇 |
中国医学 | 37篇 |
肿瘤学 | 2104篇 |
出版年
2024年 | 23篇 |
2023年 | 170篇 |
2022年 | 314篇 |
2021年 | 557篇 |
2020年 | 321篇 |
2019年 | 425篇 |
2018年 | 448篇 |
2017年 | 357篇 |
2016年 | 436篇 |
2015年 | 465篇 |
2014年 | 622篇 |
2013年 | 741篇 |
2012年 | 1237篇 |
2011年 | 1394篇 |
2010年 | 815篇 |
2009年 | 611篇 |
2008年 | 1056篇 |
2007年 | 1224篇 |
2006年 | 1145篇 |
2005年 | 1122篇 |
2004年 | 1040篇 |
2003年 | 964篇 |
2002年 | 999篇 |
2001年 | 225篇 |
2000年 | 188篇 |
1999年 | 203篇 |
1998年 | 205篇 |
1997年 | 195篇 |
1996年 | 162篇 |
1995年 | 130篇 |
1994年 | 111篇 |
1993年 | 98篇 |
1992年 | 110篇 |
1991年 | 92篇 |
1990年 | 94篇 |
1989年 | 100篇 |
1988年 | 71篇 |
1987年 | 73篇 |
1986年 | 63篇 |
1985年 | 58篇 |
1984年 | 55篇 |
1983年 | 31篇 |
1982年 | 28篇 |
1981年 | 24篇 |
1980年 | 21篇 |
1979年 | 33篇 |
1978年 | 17篇 |
1977年 | 28篇 |
1974年 | 16篇 |
1972年 | 16篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Hirotomo Dochi Satoru Kondo Takayuki Murata Masaki Fukuyo Asuka Nanbo Kousho Wakae WenPing Jiang Toshihide HamabeHoriike Mariko Tanaka Takumi Nishiuchi Harue Mizokami Makiko MoriyamaKita Eiji Kobayashi Nobuyuki Hirai Takeshi Komori Takayoshi Ueno Yosuke Nakanishi Miyako Hatano Kazuhira Endo Hisashi Sugimoto Naohiro Wakisaka ShinHun Juang Masamichi Muramatsu Atsushi Kaneda Tomokazu Yoshizaki 《Cancer science》2022,113(8):2862
92.
Atsushi Sato Ken Shimada Masatoshi Nakamachi Jun Ushio Wataru Yamamoto Minoru Kurihara Masaaki Matsukawa 《Gastric cancer》2002,5(4):0233-0236
A 58-year-old man was diagnosed as having type 3 gastric cancer (poorly differentiated adenocarcinoma). He underwent total
gastrectomy with splenectomy, as well as D3 dissection, and received postoperative chemotherapy combining oral uracil and
futrafur (UFT) with cisplatin (CDDP), but results showed recurrence of multiple abdominal lymph node metastases around the
aorta. He therefore received various anticancer drug regimens (irinotecan [CPT-11]/CDDP; 1 M tegafur-0.4 M gimeracil-1 M oteracil
potassium [TS-1], methotrexate (MTX)/5-fluorouracil); however, final results showed growth of lymph node metastasis and simultaneous
worsening of his general condition. The patient then received combined administration of doxifluridine (5′-DFUR)/docetaxel
(5′-DFUR, 1000 mg/body [666.7 mg/m
2
], given by consecutive daily administration, orally, for days 1–14; and docetaxel, 80 mg/body [60 mg/m
2
], on day 8, by venous drip, every 3 weeks). Three courses of this regimen resulted in approximately 90% reduction of the
abdominal lymph node size, disappearance of the right cervical lymph node metastasis, reductions of the levels of two tumor
markers (carcinoembryonic antigen [CEA] and carbohydrate antigen [CA]19-9), and improvement of his general condition. In total,
seven courses of the regimen were carried out. The patient died on day 298 after starting this combined regimen and showed
a response period of 126 days. The primary toxicity identified was neutropenia (grade 4), as well as other low-grade (grade
1, 2) hematological and nonhematological toxicities. In the field of gastric cancer treatment, especially for patients showing
multiple resistance to anticancer drugs, an effective therapy is critically needed.
Received: January 15, 2002 / Accepted: July 8, 2002
Offprint requests to: A. Sato 相似文献
93.
Rheumatoid factors (RF) were associated with alterations of antibody reactions to melanoma cells in vitro by two serologic assays. Removal of RF from melanoma patients' sera by absorption with Cohn's Fraction II coated latex particles enhanced seroreactivity in the Immune Adherence (IA) assay and diminished IgM detection by the Indirect Membrane Immunofluorescence (IMI) assay. The addition of serum with high titers of RF to these assay systems led to diminution of IA reactivity and enhancement of IgM detection by IMI. Since these factors are found in cancer patients' sera and can alter humoral immune reactions directed against antigens on the membranes of tumor cells, their presence should be recognized when performing assays with tumor target cells. RF may be of significance in the host-tumor relationship in vivo. 相似文献
94.
95.
96.
Runa Emoto Shoichiro Yatsu Takuma Yoshihara Eiryu Sai Tadashi Miyazaki Taira Yamamoto Atsushi Amano Hiroyuki Daida Katsumi Miyauchi 《Internal medicine (Tokyo, Japan)》2022,61(10):1549
Mid-aortic syndrome (MAS) is a rare vascular disorder that causes refractory hypertension. A 76-year-old woman was hospitalized for acute heart failure (HF) with drug-resistant hypertension; other comorbidities included epigastric artery rupture, old myocardial infarction, an intraventricular thrombus, and a cerebral artery aneurysm. Angiography revealed severe narrowing of the descending aorta, which led to the diagnosis of MAS. Although intensive medical treatment improved her HF, optimal blood pressure (BP) could not be achieved. Percutaneous coronary intervention and surgical bypass for diseased aorta was then performed in two stages, resulting in the achievement of optimal BP and alleviation of HF. 相似文献
97.
98.
Utano Nakamura Taichi Nohmi Riho Sagane Jun Hai Kento Ohbayashi Maiko Miyazaki Atsushi Yamatsu Mujo Kim Yusaku Iwasaki 《Nutrients》2022,14(12)
Gamma-aminobutyric acid (GABA) is present in the mammalian brain as the main inhibitory neurotransmitter and in foods. It is widely used as a supplement that regulates brain function through stress-reducing and sleep-enhancing effects. However, its underlying mechanisms remain poorly understood, as it is reportedly unable to cross the blood–brain barrier. Here, we explored whether a single peroral administration of GABA affects feeding behavior as an evaluation of brain function and the involvement of vagal afferent nerves. Peroral GABA at 20 and 200 mg/kg immediately before refeeding suppressed short-term food intake without aversive behaviors in mice. However, GABA administration 30 min before refeeding demonstrated no effects. A rise in circulating GABA concentrations by the peroral administration of 200 mg/kg GABA was similar to that by the intraperitoneal injection of 20 mg/kg GABA, which did not alter feeding. The feeding suppression by peroral GABA was blunted by the denervation of vagal afferents. Unexpectedly, peroral GABA alone did not alter vagal afferent activities histologically. The coadministration of a liquid diet and GABA potentiated the postprandial activation of vagal afferents, thereby enhancing postprandial satiation. In conclusion, dietary GABA activates vagal afferents in collaboration with meals or meal-evoked factors and regulates brain function including feeding behavior. 相似文献
99.
The optical Freedericksz transition (OFT) can reversibly control the molecular orientation of liquid crystals (LCs) only by light irradiation, leading to the development of all-optical devices, such as smart windows. In particular, oligothiophene-doped LCs show the highly sensitive OFT due to the interaction between dyes and an optical-electric field. However, the sensitivity is still low for the application to optical devices. It is necessary to understand the factors in LCs affecting the OFT behavior to reduce the sensitivity. In this study, we investigated the effect of the host LC structure on the OFT in oligothiophene-doped LCs. The threshold light intensity for the OFT in trifluorinated LCs was 42% lower than that in LCs without fluorine substituents. This result contributes to the material design for the low-threshold optical devices utilizing the OFT of dye-doped LCs. 相似文献
100.
Tomoki Kuge Kiyoharu Fukushima Yuki Matsumoto Haruko Saito Yuko Abe Eri Akiba Kako Haduki Tadayoshi Nitta Akira Kawano Michio Tanaka Yumi Hattori Takahiro Kawasaki Takanori Matsuki Takayuki Shiroyama Daisuke Motooka Kazuyuki Tsujino Keisuke Miki Masahide Mori Seigo Kitada Shota Nakamura Tetsuya Iida Atsushi Kumanogoh Hiroshi Kida 《Emerging infectious diseases》2022,28(7):1437
Unidentified Mycobacterium species are sometimes detected in respiratory specimens. We identified a novel Tsukamurella species (Tsukamurella sp. TY48, RIMD 2001001, CIP 111916T), Tsukamurella toyonakaense, from a patient given a misdiagnosis of nontuberculous mycobacterial pulmonary disease caused by unidentified mycobacteria. Genomic identification of this Tsukamurella species helped clarify its clinical characteristics and epidemiology. 相似文献