全文获取类型
收费全文 | 210936篇 |
免费 | 2960篇 |
国内免费 | 288篇 |
专业分类
耳鼻咽喉 | 1386篇 |
儿科学 | 7443篇 |
妇产科学 | 3488篇 |
基础医学 | 20804篇 |
口腔科学 | 2392篇 |
临床医学 | 14625篇 |
内科学 | 40894篇 |
皮肤病学 | 1435篇 |
神经病学 | 19304篇 |
特种医学 | 10078篇 |
外科学 | 34478篇 |
综合类 | 2497篇 |
一般理论 | 4篇 |
预防医学 | 18892篇 |
眼科学 | 3449篇 |
药学 | 11819篇 |
中国医学 | 683篇 |
肿瘤学 | 20513篇 |
出版年
2023年 | 267篇 |
2022年 | 528篇 |
2021年 | 887篇 |
2020年 | 509篇 |
2019年 | 689篇 |
2018年 | 22596篇 |
2017年 | 17864篇 |
2016年 | 20117篇 |
2015年 | 1710篇 |
2014年 | 1824篇 |
2013年 | 2009篇 |
2012年 | 8891篇 |
2011年 | 23053篇 |
2010年 | 19992篇 |
2009年 | 12419篇 |
2008年 | 21112篇 |
2007年 | 23586篇 |
2006年 | 2445篇 |
2005年 | 4090篇 |
2004年 | 5124篇 |
2003年 | 5975篇 |
2002年 | 4204篇 |
2001年 | 1324篇 |
2000年 | 1411篇 |
1999年 | 1125篇 |
1998年 | 660篇 |
1997年 | 587篇 |
1996年 | 495篇 |
1995年 | 366篇 |
1994年 | 343篇 |
1993年 | 288篇 |
1992年 | 627篇 |
1991年 | 616篇 |
1990年 | 674篇 |
1989年 | 575篇 |
1988年 | 503篇 |
1987年 | 494篇 |
1986年 | 413篇 |
1985年 | 437篇 |
1984年 | 319篇 |
1983年 | 223篇 |
1982年 | 151篇 |
1979年 | 223篇 |
1978年 | 153篇 |
1977年 | 150篇 |
1974年 | 153篇 |
1970年 | 151篇 |
1969年 | 151篇 |
1968年 | 159篇 |
1967年 | 141篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
22.
23.
Takao Itoi Atsushi Sofuni Fumihide Itokawa Yasushi Shinohara Kazuya Takeda Kazuto Nakamura Toshio Kurihara Takayoshi Tsuchiya Fuminori Moriyasu 《Digestive endoscopy》2006,18(3):232-238
We describe our methods and outcomes of multidisciplinary treatments in patients with unresectable hilar cholangiocarcinoma. Fifty‐seven patients with a known outcome were enrolled. Thirty‐four of 57 patients were treated and evaluated by salvage therapy. For salvage therapy, we used internal and external radiotherapy, photodynamic therapy, YAG laser therapy and microwave coagulation therapy. The median survival time was 548 days for the group receiving salvage therapy and 198 days for the group not receiving this treatment. In conclusion, although no randomization of the patients was performed in this retrospective study, our present data provide convincing evidence that salvage therapy is a useful therapeutic approach for unresectable hilar cholangiocarcinomas. 相似文献
24.
S. Nishida J. J. Gaynor N. Nakamura F. Butt H. G. Illanes J. Kadono G. W. Neff D. M. Levi J. I. Moon G. Selvaggi T. Kato P. Ruiz A. G. Tzakis J. R. Madariaga 《American journal of transplantation》2006,6(1):140-149
A retrospective study of 1058 liver transplant recipients was performed to determine: (i) the incidence, etiology, timing, clinical features and treatment of refractory ascites (RA), (ii) risk factors for RA development, (iii) predictors of RA disappearance, (iv) predictors of survival following RA and (v) the impact of RA on patient survival. Sixty-two patients (5.9%) developed RA and its disappearance occurred in 27/62 cases. Patients having hepatitis C virus (HCV) had a significantly higher hazard rate of developing RA (p < 0.00001). No other baseline characteristic was associated with RA. Cox stepwise regression analysis of the hazard rate of RA disappearance found two significant factors: HCV recurrence as the reason for developing RA implied a poorer outcome (p = 0.006), whereas an unknown reason implied a favorable outcome (p = 0.02). In addition, survival following RA was significantly poorer among patients having bacterial peritonitis or HCV recurrence. Finally, the mortality rate was significantly (nearly 8.6 times) higher in patients following RA development while it was ongoing (p < 0.00001); however, if the RA disappeared, then the additional risk of death also disappeared. This study illustrates the importance of developing an optimal treatment strategy to (i) effectively treat RA if it develops and (ii) prevent hepatitis C recurrence. 相似文献
25.
Masahiro Yamauchi Hiroko Kusano Etsuko Saito Takeshi Iwata Masashi Nakakura Yasuki Kato Takaaki Uochi Shiro Akinaga Noboru Aoki 《Journal of controlled release》2006,114(2):268-275
Previously, we demonstrated that wrapping dextran fluorescein anionic/cationic lipid complexes with neutral lipids produced a stable formulation that markedly increased the duration of the compound in plasma after intravenous administration to rats. The improved drug-delivery properties of the wrapped liposomes (WL) relative to other formulations suggested that this technology could offer important advantages for the administration of other polyanionic drugs, including antisense oligodeoxynucleotides (ODN). In the present study, we investigated the value of WL for formulating fluorescence-labeled phosphorothioated ODN (F-ODN). WL encapsulating F-ODN/cationic lipid complexes were prepared efficiently using similar methodology to that used in our earlier study. Studies confirmed that these WL were stable in vitro. Following intravenous administration to mice, free F-ODN and naked F-ODN/cationic lipid complexes were rapidly eliminated whereas administration of the WL resulted in high blood concentrations of drug that were maintained for several hours. Additional studies were conducted in mice that were inoculated with tumor cells (Caki-1 xenograft model, human kidney); in these experiments, intravenous administration of WL delivered 13 times more F-ODN to the tumor site than achieved after injection of free F-ODN. 相似文献
26.
27.
28.
29.
30.