全文获取类型
收费全文 | 9200篇 |
免费 | 373篇 |
国内免费 | 68篇 |
专业分类
耳鼻咽喉 | 94篇 |
儿科学 | 80篇 |
妇产科学 | 66篇 |
基础医学 | 1055篇 |
口腔科学 | 294篇 |
临床医学 | 730篇 |
内科学 | 1967篇 |
皮肤病学 | 276篇 |
神经病学 | 586篇 |
特种医学 | 513篇 |
外科学 | 1806篇 |
综合类 | 53篇 |
一般理论 | 1篇 |
预防医学 | 396篇 |
眼科学 | 106篇 |
药学 | 729篇 |
中国医学 | 29篇 |
肿瘤学 | 860篇 |
出版年
2023年 | 49篇 |
2022年 | 98篇 |
2021年 | 164篇 |
2020年 | 98篇 |
2019年 | 132篇 |
2018年 | 177篇 |
2017年 | 114篇 |
2016年 | 160篇 |
2015年 | 149篇 |
2014年 | 216篇 |
2013年 | 256篇 |
2012年 | 434篇 |
2011年 | 478篇 |
2010年 | 271篇 |
2009年 | 201篇 |
2008年 | 392篇 |
2007年 | 418篇 |
2006年 | 400篇 |
2005年 | 397篇 |
2004年 | 415篇 |
2003年 | 394篇 |
2002年 | 362篇 |
2001年 | 303篇 |
2000年 | 315篇 |
1999年 | 306篇 |
1998年 | 140篇 |
1997年 | 74篇 |
1996年 | 69篇 |
1995年 | 81篇 |
1994年 | 69篇 |
1993年 | 52篇 |
1992年 | 219篇 |
1991年 | 198篇 |
1990年 | 219篇 |
1989年 | 220篇 |
1988年 | 174篇 |
1987年 | 192篇 |
1986年 | 160篇 |
1985年 | 154篇 |
1984年 | 102篇 |
1983年 | 82篇 |
1981年 | 50篇 |
1979年 | 95篇 |
1978年 | 41篇 |
1977年 | 52篇 |
1974年 | 47篇 |
1972年 | 39篇 |
1971年 | 40篇 |
1969年 | 45篇 |
1968年 | 40篇 |
排序方式: 共有9641条查询结果,搜索用时 0 毫秒
21.
22.
Predicting recurrence time of esophageal carcinoma through assessment of histologic factors and DNA ploidy 总被引:3,自引:0,他引:3
Cytophotometric analysis of nuclear DNA content was done in 128 patients with squamous cell carcinoma of the esophagus. The relationship among histopathologic features, DNA distribution pattern, and survival time was investigated from the standpoint of recurrence. Of 128 patients, 77 (60.1%) died of recurrence within 2 years after surgery: 16 (12.5%) from 2 to 5 years and two (1.6%) over 5 years. The rate of death of recurrence within 2 years was higher in patients with T4 or N1 than T1, T2, and T3 or N0 (P less than 0.01). Survivors over 5 years more frequently possessed type II DNA pattern than types III and IV (P less than 0.05). The rate of death of recurrence within 2 years was 34.4% in type II, which was lower than the 59.6% rate in type III (P less than 0.05) and the 76.6% rate in type IV (P less than 0.01). Survivors from 2 to 5 years were higher in type III than in type IV (P less than 0.05), and recurrence over 5 years was found only in type II. This inclination was more apparent in those with curative resection. In the patients with type II, careful follow-up may be needed over 5 years for late recurrence. However, in those with type IV, no recurrence over 2 years could be regarded as healed because most of their recurrences occur within 2 years. These findings suggest that the growth rate of esophageal carcinoma should reflect DNA aneuploidy, and the DNA analysis of esophageal carcinoma should be a valuable parameter for postoperative follow-up planning. 相似文献
23.
Neural control of urinary sodium excretion during hypertonic NaCl load in conscious rabbits: role of renal and hepatic nerves and baroreceptors 总被引:5,自引:0,他引:5
We examined responses of renal nerve activity, urine flow, and urinary Na+ excretion to a hypertonic NaCl infusion in chronically instrumented conscious rabbits with unilateral renal denervation. The intravenous infusion of 20% NaCl, at 0.2 ml/min for 30 min, increased plasma osmolality by 27 +/- 5 mOsm/kg, and plasma Na+ by 16 +/- 3 mEq/l, and decreased hematocrit by 5 +/- 1%. These changes were accompanied by a marked decrease in renal nerve activity by 82 + 7%. Urine flow and urinary Na+ excretion increased gradually and peaked at the end of infusion. The innervated kidney excreted 23.3 +/- 3.3 ml urine and 5.5 +/- 0.7 mEq Na+ for the subsequent 60 min. However, the contralateral denervated kidney excreted only 9.5 +/- 2.0 ml urine and 2.2 +/- 0.6 mEq Na+; these values were significantly less than those of the innervated kidney. To examine the role of the sinoaortic and cardiopulmonary baroreceptors and the hepatic nerves in the response of renal nerve activity to the hypertonic NaCl infusion, renal nerve activity was examined in conscious rabbits with sinoaortic baroreceptor denervation (SAD) plus vagotomy and/or section of the anterior and posterior hepatic nerves (SAPH). In rabbits with SAD plus vagotomy or SAPH, the NaCl infusion also decreased renal nerve activity. After combining SAPH and SAD plus vagotomy, the decrease in renal nerve activity was completely blocked. These results indicate that hypertonic NaCl infusion elicits a marked decrease in renal nerve activity which is mediated predominantly by sinoaortic and cardiopulmonary baroreflexes and the hepatic nerves, and that the decrease in renal nerve activity plays an important role in the augmentation of renal function. 相似文献
24.
The reflex effects of hepatic osmoreceptors on the renal sympathetic nerve activity (RNA) were studied in 30 pentobarbital anesthetized, vagotomized and sino-aortic baroreceptor denervated (SAD + VD) rabbits. The changes in mean arterial pressure (MAP), heart rate (HR), and RNA were examined when 9% NaCl, 6.5% LiCl or 50% glucose solution was infused into the hepatic portal vein at a rate of 0.15 ml/kg/min for 10 min. Infusion of 9% NaCl solution into the hepatic portal vein increased the plasma osmolality by 10.8 +/- 1.0 mOsmol/kg from the control level in the blood of the hepatic portal vein and by 2.8 +/- 2.0 mOsmol/kg from the control level in the systemic blood. MAP was significantly elevated by 10.2 +/- 5.0 mmHg but HR did not change with hepatic portal infusion of 9% NaCl solution. Intraportal infusion of 9% NaCl solution significantly decreased the RNA by 28.6-34.2% from the control level, 6.5% LiCl solution by 28.6 +/- 4.7%, and 50% glucose solution by 26.2 +/- 3.0%. Femoral arterial infusion of hypertonic NaCl solution, however, did not evoke any significant change in RNA in SAD + VD rabbits. These findings suggest that increases in osmolality and NaCl concentration in the systemic circulation do not result in a decrease of RNA. Furthermore, after section of the anterior and posterior plexus of the hepatic nerve, hepatic portal infusion of hypertonic NaCl solution elicited no change in RNA. The present data indicate that an increase in osmolality in the hepatic portal venous blood results in a reflex decrease of RNA. This reflex may be important for restoration of a postprandial increase in osmolality. 相似文献
25.
Genetic alteration in carcinoid tumors of the lung. 总被引:1,自引:0,他引:1
Kenji Sugio Toshihiro Osaki Tsunehiro Oyama Mitsuhiro Takenoyama Takeshi Hanagiri Masaru Morita Koji Yamazaki Akira Nagashima Hisashi Nakahashi Yoshihiko Maehara Kosei Yasumoto 《Annals of thoracic and cardiovascular surgery》2003,9(3):149-154
Surgically resected specimens of 13 carcinoid tumors of the lung including nine typical carcinoids and four atypical carcinoids, and eight salivary gland type carcinomas (six mucoepidermoid carcinomas and two adenoid cystic carcinomas) were analyzed regarding p53 expression, loss of heterozygosity (LOH) in chromosome 3p, 9p, and K-ras mutation. The overexpression of p53 was identified in four atypical carcinoid tumors, one mucoepidermoid carcinoma, and one adenoid cystic carcinoma, however, none of typical carcinoids showed p53 immunoreactivity. LOH in 3p14 was demonstrated in three of seven informative cases in all tumors. LOH in 9p was demonstrated in two of five informative cases in all tumors. Two of three cases with LOH at 3p14 had a poor prognosis, one of which also had LOH at 9p. No mutation of the K-ras gene was observed in any of these tumors. These data thus indicate that p53 overexpression might distinguish atypical carcinoid tumors from typical tumors and might therefore be useful as an adjunct modality in the differential diagnosis of pulmonary carcinoid tumors. The presence of LOH at 3p14 or 9p may thus help to identify lung cancer patients with a poor prognosis. 相似文献
26.
A 78-year-old woman is described who presented with a diaphragmatic hernia through the foramen of Morgagni. A definitive
diagnosis was confirmed by a sagittal view on magnetic resonance imaging prior to surgery. The hernia was repaired laparoscopically
under an abdominal wall lifting technique without pneumoperitoneum, and her symptoms completely resolved postoperatively with
no evidence of recurrence. The laparoscopic repair was considered a suitable and safe procedure for the treatment of a Morgagni
hernia.
Received: 3 April 1996/Accepted: 3 May 1996 相似文献
27.
Mitsuhiro Morita Harumoto Yamada Osamu Hemmi Kyosuke Fujikawa 《Journal of orthopaedic science》2004,9(1):99-102
In acetabular dysplasia of the hip joint accompanied by a giant acetabular bone cyst, rotational acetabular osteotomy may cause serious complications, such as bone necrosis after surgery or fracture of the fragile acetabulum during the operation. In a patient with this condition, we performed a two-stage operation: first, autogenous bone grafting supplemented with hydroxyapatite filling, then rotational acetabular osteotomy (after new bone formation had been assured). Radiographs and CT scans showed favorable fusion of the grafted bone. Some 18 months after the second operation, arthrograms showed no inflow of contrast medium from the articular cavity into the bone cyst region, although this had been observed before treatment. Thus, an effective remodeling of bony congruency was indicated in the mobile acetabulum 5 years after the second operation. This two-stage operation appears to be useful for correcting acetabular dysplasia accompanied by a giant bone cyst and to carry a reduced risk of serious complications, such as deterioration of the articular surface of the acetabulum or necrosis of the translocated acetabulum. 相似文献
28.
Hideki Aragane Hideki Fujii Takaharu You Atuhiro Morita Morimichi Miyazaki Kiyoshi Morita Tohru Ohkawara Shinji Fukumitu Yoshihiko Sawa Yasuo Ohkawara 《Nihon Shokakibyo Gakkai zasshi》2006,103(5):537-542
This report describes our experience with a 60 year old male who suffered from a recrudescence of groove pancreatitis. He had been treated by conservative medication therapy by proton pump inhibitor used for therapy of duodenal ulcer, and was in remission. During a follow-up one year later, endoscopy revealed gastric cancer, for which a proximal gastrectomy and vagotomy were performed. The patient continues to remain in remission for the groove pancreatitis. Our experience with the clinical course of this disease, in which treatment for duodenal ulcer was used effectively, offers new insights into the progression and therapy of groove pancreatitis. 相似文献
29.
S Minohara S Sasaki K Asada H Muraki T Kodama S Hasegawa M Morita E Tsujii A Takeuchi 《Kyobu geka. The Japanese journal of thoracic surgery》1992,45(12):1106-1108
The patient was a one-year-old boy, who underwent surgery with a diagnosis of atrial septal defect (ASD). During operation, aorto-pulmonary window (A-P window) which had not been detected by the preoperative examinations, was found. Therefore, the A-P window was divided prior to closing ASD. The patient is in good condition six months after the operation. The causes of the inaccurate preoperative diagnosis were discussed. 相似文献
30.
Yoshihiro Sei Taizo Hamaguchi Junya Ninomiya Atsuhiro Nakabayashi Iwao Takiuchi 《The Journal of dermatology》1994,21(5):334-340
In order to elucidate the effectiveness of anti-mycotics in treating seborrhoeic dermatitis, an attempt was made to isolate Malassezia from seborrhoeic lesions of patients of seborrhoeic dermatitis. The results revealed that, in male patients, 46/49 cases were positive for Malassezia furfur on the face and 30/48 cases were positive for M. furfur on the scalp. In female patients, 7/13 cases were positive for M. furfur on the face, and 6/17 cases were positive for M. furfur on the scalp. Anti-mycotic agents were excellent in 50% and good in 31% of the spore-positive cases, yielding an overall efficacy rate of 81%. In contrast, the treatment of the face with vehicle alone showed only one excellent result out of 8 cases. Although clinical improvement was rapid on the side treated with a topical corticosteroid in the half-side-test, numerous fungal elements remained. While the improvement with anti-mycotic agents was slower than that with the corticosteroid, clinical improvement became evident by the third week of administration and fungal elements disappeared. 相似文献