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121.
胸腔镜下前路松解结合后路矫形治疗Scheuermann病后凸畸形 总被引:2,自引:0,他引:2
目的探讨胸腔镜下前路松解结合后路矫形治疗Scheuermann病后凸畸形的效果。方法对16例Scheuermann病后凸畸形患者在胸腔镜下行前路松解、椎间盘摘除、植骨融合,结合后路矫形内固定。手术前后及随访期间测量后凸畸形Cobb角,了解后凸畸形矫正情况。评定术前及术后Oswestry功能障碍指数,了解背部疼痛缓解情况。结果16例后凸畸形患者均获得满意矫形,术前Cobb角平均788°(70°~92°),术后平均405°(36°~47°),最后一次随访平均417°(36°~50°)。患者背部疼痛症状明显改善,Oswestry功能障碍指数术前平均373(0~72),术后平均64(0~30)。结论胸腔镜下前路松解结合后路矫形是一种较好的治疗Scheuermann病后凸畸形的手术方法。 相似文献
122.
Salehi F Scheithauer BW Kros JM Lau Q Fealey M Erickson D Kovacs K Horvath E Lloyd RV 《Journal of neuro-oncology》2011,104(3):647-657
MGMT promoter hypermethylation of aggressive pituitary adenomas and pituitary carcinomas and low protein expression are implicated
in improved response to treatment with temozolomide (TMZ). The aim of the present study was to investigate MGMT promoter methylation
and immunoexpression in an aggressive subset of pituitary adenomas and carcinomas. Our material consisted of 12 silent subtype
3 (SS3) adenomas, 10 primary carcinomas, and 4 disseminated metastases. Two different tissue samples of 7 of the 12 SS3 adenomas
and all carcinomas were analyzed for MGMT promoter methylation and immunohistochemical expression of MGMT. Immunoexpression
was assessed semi-quantitatively as a percentage of immunoreactive nuclei. Overall 33% of carcinomas exhibited homogenous
MGMT methylation in tumor and metastatic specimens. Low immunohistochemical MGMT expression was noted in 50% of carcinomas.
Overall, 42% of the SS3 adenomas exhibited MGMT promoter methylation. MGMT immunostaining was predominantly negative (92%),
with homogenous immunostaining results across different samples. Whereas all the methylated SS3 adenomas had low MGMT immunoreactivity,
five unmethylated adenomas exhibited absent/low MGMT expression. There was no relationship between methylation status and
MGMT immunoexpression was not apparent. MGMT methylation and low immunohistochemical expression seen in a subset of carcinomas
and SS3 adenomas, suggesting that a subset of tumors may respond to treatment with TMZ. Heterogeneous MGMT methylation status
in SS3 adenomas and the lack of concordance between methylation and immunohistochemical expression of MGMT suggest complex
regulatory mechanisms, highlighting the need for improved methods in the research on a correlation between MGMT changes and
response to TMZ. 相似文献
123.
Background: Ameloblastoma, a benign but locally aggressive tumor, accounts for 9% to 11% of all odontogenic tumors. Radical procedures, including resection, are performed. To restore functions after resection, free vascularized iliac grafts followed by a dental implant–supported prosthesis are used as a successful treatment option. The aim of this case report is to evaluate the peri‐implant clinical status and stability of dental implants placed in patients with advanced‐stage mandibular ameloblastomas. Methods: Examinations of three patients revealed extensive ameloblastomas, and hemimandibulectomies were performed. Six months after surgeries, two to four dental implants were placed. After 6 months of healing, one fixed prosthesis and two removable prostheses were delivered. The stability of implants was evaluated at the surgical baseline and 1, 3, 6, 9, and 12 months after surgery by resonance‐frequency (RF) analysis. Peri‐implant clinical parameters (i.e., plaque index [PI], gingival index [GI], gingival bleeding time index [GBTI], and peri‐implant probing depth [PD]) were recorded at the delivery of the prosthesis and at follow‐ups at 1, 3, and 6 months. Results: Nine implants that supported one removable prosthesis and two fixed prostheses were placed. RF analysis revealed no significant changes in implant stability during 12 months of follow‐up. Peri‐implant clinical parameters (PI, GI, and GBTI) showed slight improvements during follow‐up. Although advancements were observed in 6 months, PDs were found to be deeper than optimal measurements for the whole observation time. Conclusion: The implant‐supported prosthetic rehabilitation of patients with ameloblastomas reconstructed with free vascularized iliac crest grafts can be a predictive alternative for improving the quality of life of patients in which a high implant stability and acceptable peri‐implant health may be achieved. 相似文献
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Elif Basagan-Mogol Suna Goren Gulsen Korfali Gurkan Turker Fatma Nur Kaya 《Clinics (S?o Paulo, Brazil)》2010,65(2):133-138
OBJECTIVE
The aim of this prospective, randomized study was to evaluate the hemodynamic and analgesic effects of ketamine by comparing it with propofol starting at the induction of anesthesia until the end of sternotomy in patients undergoing coronary artery bypass grafting surgery.INTRODUCTION
Anesthetic induction and maintenance may induce myocardial ischemia in patients with coronary artery disease. A primary goal in the anesthesia of patients undergoing coronary artery bypass grafting surgery is both the attenuation of sympathetic responses to noxious stimuli and the prevention of hypotension.METHODS
Thirty patients undergoing coronary artery bypass grafting surgery were randomized to receive either ketamine 2 mg.kg−1 (Group K) or propofol 0.5 mg.kg−1 (Group P) during induction of anesthesia. Patients also received standardized doses of midazolam, fentanyl, and rocuronium in the induction sequence. The duration of anesthesia from induction to skin incision and sternotomy, as well as the supplemental doses of fentanyl and sevoflurane, were recorded. Heart rate, mean arterial pressure, central venous pressure, pulmonary arterial pressure, pulmonary capillary wedge pressure, cardiac index, systemic and pulmonary vascular resistance indices, stroke work index, and left and right ventricular stroke work indices were obtained before induction of anesthesia; one minute after induction; one, three, five, and ten minutes after intubation; one minute after skin incision; and at one minute after sternotomy.RESULTS
There were significant changes in the measured and calculated hemodynamic variables when compared to their values before induction. One minute after induction, mean arterial pressure and the systemic vascular resistance index decreased significantly in group P (p<0.01).CONCLUSION
There were no differences between groups in the consumption of sevoflurane or in the use of additional fentanyl. The combination of ketamine, midazolam, and fentanyl for the induction of anesthesia provided better hemodynamic stability during induction and until the end of sternotomy in patients undergoing coronary artery bypass grafting surgery. 相似文献129.
130.
Erdogan Askin Kose Fatih Akkaya Hampar Neslihan Bascil Tutuncu Ozyilkan Ozgur 《Journal of gastrointestinal cancer》2010,41(4):272-274