THE TREATMENT OF TETANUS REPORT OF A CASE OF LOCAL TETANUS

Tetanus is described in ancient Chinese medical literature (1). The most prevalent types now seen are tetanus neonatorum and tetanus which has developed in deep penetratin9 wounds, or in flesh wounds on which Chinese native plaster, incense powder or dirt has beenapplied as a styptic. Recently we have seen many cases of tetanus in which no prophylactic tetanus antitoxin had been given in shrapnel and bulIet penetrating wounds, especially those of a lacerating or crushing nature.     

Increased intracranial pressure in a patient with Congenital Heart Defect and Ectodermal Dysplasia (CHDED): Extension of phenotype and review of literature

Congenital heart defect (CHD) is a birth defect that affects the structure of the heart. Although CHD is often multifactorial, it can also be inherited as part of a Mendelian disorder such as in congenital heart defect and ectodermal dysplasia (CHDED). This disorder is caused by de novo variants in PRKD1. Here, we describe a patient with a novel de novo variant of PRKD1 with phenotypic features consistent with CHDED. Previously unreported features were noted including high intracranial pressure (ICP), partial anomalous pulmonary venous return (PAPVR), and bifid uvula. We suggest that these features may be associated with CHDED.