Some toxicological aspects of polycyclic aromatic hydrocarbons (PAHs) effects

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants. They are found through environment in the air, in the soil, in water, in plants, and also in food. PAHs are formed during pyrolisis and the incomplete combustion of organic materials. PAHs can be man-made or occur naturally. They undergo metabolic activation after entering the mammalian cells to highly toxic reactive metabolite intermediates and can irreversibly damage cellular macromolecules (DNA, proteins, lipids). Polycyclic aromatic hydrocarbons represent a class of toxicological compounds which can create a variety of hazardous effects in vivo, including cytotoxicity, genotoxicity, immunotoxicity, teratogenicity and carcinogenesis described in present paper.     

Spinal deformities after laminectomy in children

The authors discuss the problem of spinal deformity developing after laminectomy in the light of treated case. Clinical observations and literature survey indicate the necessity of orthopaedic consultation before operations impairing stabilization of the spine. Laminectomy, particularly with disturbance of the stability of articular processes is an indication to spondylodesis, and the presence of kyphosis and absence of posterior spinal elements are the primary indication to anterior spondylodesis.     

实验性短期电刺激引起的机体紊乱

SourcepapersdealingwiththeuseofLateralElectricSurfaceStimulation（LESS）totreatidiopathicscoliosis（IS）inchildrenandadolescentshavesofarpresentedcontroversialopinions犤５，６，８，１０，１２，１６，１７犦．Authorsrecommendingthistreatmentusuallyapplyitfor９hoursatnight．Theymention，however，thatthetherapywhichmaylastuntilthebonesarefullydeveloped，oftenresultsinskincomplications，e．g．burns，emotionalandpsychicaldiscomfortofpatientsduringnoc－turnalrest，aswellasstressorevendisturbances…