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991.
Orna Staretz-Chacham Iris Noyman Ohad Wormser Abed Abu Quider Guy Hazan Iris Morag Noam Hadar Kimiyo Raymond Ohad S. Birk Carlos R. Ferreira Arie Koifman 《Clinical genetics》2020,97(6):920-926
A congenital disorder of glycosylation due to biallelic mutations in B4GALT1 has been previously reported in only three patients with two different mutations. Through homozygosity mapping followed by segregation analysis in an extended pedigree, we identified three additional patients homozygous for a novel mutation in B4GALT1, expanding the phenotypic spectrum of the disease. The patients showed a uniform clinical presentation with intellectual disability, marked pancytopenia requiring chronic management, and novel features including pulmonary hypertension and nephrotic syndrome. Notably, affected individuals exhibited a moderate elevation of Man3GlcNAc4Fuc1 on serum N-glycan analysis, yet two of the patients had a normal pattern of transferrin glycosylation in repeated analysis. The novel mutation is the third disease-causing variant described in B4GALT1, and the first one within its transmembrane domain. 相似文献
992.
David N. Louis Pieter Wesseling Kenneth Aldape Daniel J. Brat David Capper Ian A. Cree Charles Eberhart Dominique Figarella‐Branger Maryam Fouladi Gregory N. Fuller Caterina Giannini Christine Haberler Cynthia Hawkins Takashi Komori Johan M. Kros HK Ng Brent A. Orr Sung‐Hye Park Werner Paulus Arie Perry Torsten Pietsch Guido Reifenberger Marc Rosenblum Brian Rous Felix Sahm Chitra Sarkar David A. Solomon Uri Tabori Martin J. van den Bent Andreas von Deimling Michael Weller Valerie A. White David W. Ellison 《Brain pathology (Zurich, Switzerland)》2020,30(4):844-856
cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recommendations on recent advances in the field of CNS tumor classification, particularly in light of the rapid progress in molecular insights into these neoplasms. For Round 2 of its deliberations, cIMPACT‐NOW Working Committee 3 was reconstituted and convened in Utrecht, The Netherlands, for a meeting designed to review putative new CNS tumor types in advance of any future World Health Organization meeting on CNS tumor classification. In preparatory activities for the meeting and at the actual meeting, a list of possible entities was assembled and each type and subtype debated. Working Committee 3 recommended that a substantial number of newly recognized types and subtypes should be considered for inclusion in future CNS tumor classifications. In addition, the group endorsed a number of principles—relating to classification categories, approaches to classification, nomenclature, and grading—that the group hopes will also inform the future classification of CNS neoplasms. 相似文献
993.
994.
995.
Andrea Cerase Daniel Smeets Y. Amy Tang Michal Gdula Felix Kraus Mikhail Spivakov Benoit Moindrot Marion Leleu Anna Tattermusch Justin Demmerle Tatyana B. Nesterova Catherine Green Arie P. Otte Lothar Schermelleh Neil Brockdorff 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(6):2235-2240
996.
Sleep and Breathing - We assessed the prevalence of positional patients (PPs) and the main predictors of positional dependency in severe obstructive sleep apnea (OSA). A simulated effect of... 相似文献
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998.
Prashant Bhangui Chady Salloum Chetana Lim Paola Andreani Arie Ariche René Adam Denis Castaing Tech Kerba Daniel Azoulay 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2014,16(8):723-738
Background
Portal vein arterialization (PVA) has been used as a salvage inflow technique when hepatic artery (HA) reconstruction is deemed impossible in liver transplantation (LT) or hepatopancreatobiliary (HPB) surgery. Outcomes and the management of possible complications have not been well described.Methods
The present study analysed outcomes in 16 patients who underwent PVA during the period from February 2005 to January 2011 for HA thrombosis post-LT (n = 7) or after liver resection (n = 1), during curative resection for locally advanced HPB cancers (requiring HA interruption) (n = 7) and for HA resection without reconstruction (n = 1). In addition, a literature review was conducted.Results
Nine patients were women. The median age of the patients was 58 years (range: 30–72 years). Recovery of intrahepatic arterial signals and PVA shunt patency were documented using Doppler ultrasound until the last follow-up (or until shunt thrombosis in some cases). Of five postoperative deaths, two occurred as a result of haemorrhagic shock, one as a result of liver ischaemia and one as a result of sepsis. The fifth patient died at home of unknown cause. Three patients (19%) had major bleeding related to portal hypertension (PHT). Of these, two underwent re-exploration and one underwent successful shunt embolization to control the bleeding. Four patients (25%) had early shunt thrombosis, two of whom underwent a second PVA. After a median follow-up of 13 months (range: 1–60 months), 10 patients (63%) remained alive with normal liver function and one submitted to retransplantation.Conclusions
Portal vein arterialization results in acceptable rates of survival in relation to spontaneous outcomes in patients with completely de-arterialized livers. The management of complications (especially PHT) after the procedure is challenging. Portal vein arterialization may represent a salvage option or a bridge to liver retransplantation and thus may make curative resection in locally advanced HPB cancers with vascular involvement feasible. 相似文献999.
Takafumi Yamaguchi Daisuke Yamamoto Takayuki Arie Seiji Akita Kuniharu Takei 《RSC advances》2020,10(29):17353
To monitor health and diagnose disease in the early stage, future healthcare standards will likely include the continuous monitoring of various vital data. One approach to collect such information is a wearable and flexible device, which detects information from the skin surface. An important dataset is heart pulse information. Herein a method to monitor the detailed pulse signal from a wrist stably and reliably is proposed. Specifically, a soft pneumatic balloon operated by a soft pump applies the appropriate pressure over a tactile sensor onto the radial artery of the wrist to detect detailed heart pulse waves. The soft pump, pneumatic balloon, and flexible tactile pressure sensor are characterized as a fundamental study. Additionally, a proof-of-concept of this integrated device platform is demonstrated by monitoring the heart pulse from a wrist with and without the soft pump functions.Wearable and flexible heart pulse sensor is proposed to monitor the detailed pulse signal from a wrist stably and reliably by integrating a tactile pressure sensor and a soft pneumatic balloon operated by a soft pump. 相似文献