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41.
Fernando Arias de la Vega Miguel Angel Domínguez Domínguez Ana Manterola Burgaleta Ruth Vera García Maria Eugenia Echeverría Zabalza Eugenio Oria Mundin Enrique Martínez López Pilar Romero Rojano Elena Villafranca Iture 《Clinical & translational oncology》2005,7(2):60-65
INTRODUCTION: This study aims to asses the effectiveness and toxicity of boost radiotherapy concomitant and concurrent cisplatin for patients with locally advanced head and neck cancer (LAHNC). MATERIAL AND METHODS: There were 30 patients included in a prospective, phase II single-institution trial and of whom, 29 were at AJCC stage IV and 1 at stage III. Treatment consisted of radiotherapy acceleration fractionation with concomitant boost, 72 Gy, and 2 cycles of concomitant cisplatin (20 mg/m2/day continuous infusion; days 1-5 and 29-33). Amifostine, (i.v. 200 mg/m2) was administered to 26 prior to the first fraction of radiotherapy. Endpoints of the study were quality-of-life (QL), overall survival, and local control of disease. RESULTS: Complete response (CR) was achieved in 23 patients (77%), 2 patients had partial response (PR) (7%), 4 had no response (13%), and 1 was not evaluated for response. The 2-year overall survival and loco-regional control were 60% and 56%, respectively. Main toxicity was grade 3 or 4 mucositis in 93% of the patients. QL scores (questionnaire QLQC30; version 3.0) and the HN cancer module QLQ-HN35) showed a worsening in areas related to the treatment e.g. dry mouth, problems stretching the mouth, and sticky saliva. CONCLUSIONS: this combination modality is active, but toxic, in the treatment for LAHNC. Concomitant boost radiotherapy is probably, not the best radiotherapy schema for combining with chemotherapy in LAHNC. 相似文献
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液基细胞学结合阴道镜检查在北京市社区妇女宫颈病变筛查中的意义 总被引:2,自引:0,他引:2
目的探讨宫颈液基细胞学及阴道镜检查在北京市社区妇女宫颈病变筛查中的临床意义。方法2006年6月至2007年6月对北京市展览路社区的795位20~54岁有性生活的妇女进行筛查。筛查对象接受妇科检查时,留取宫颈超柏氏薄层液基细胞学检测标本,并对宫颈细胞学异常者行阴道镜检查及活组织检查。结果宫颈细胞学阳性[≥ASC-US(不能明确意义的不典型鳞状细胞)]45例,占5.7%(45/795)。其中ASC-US33例,占73.3%(33/45);低度鳞状上皮内病变8例;高度鳞状上皮内病变3例;不典型腺细胞1例。细胞学阴性750例,占94.3%(750/795)。宫颈细胞学阳性的45例中,5例拒绝行阴道镜检查,占11.1%(5/45)。在行阴道镜活组织病理检查的40例中,慢性宫颈炎11例(27.5%);宫颈湿疣14例(35.0%);宫颈上皮内瘤样病变(CIN)1为7例(17.5%);CIN2为3例(7.5%);CIN3为4例(10.0%);早期浸润癌1例(2.5%)。细胞学阴性的750例中,宫颈湿疣2例(0.3%);CIN1为5例(0.7%);宫颈低级别腺上皮内病变1例(0.1%)。宫颈液基细胞学筛查CIN1及以上宫颈病变和宫颈癌的敏感度71.4%,特异度94.2%,阳性预测值37.5%,阴性预测值99.2%;筛查CIN2及以上宫颈病变和宫颈癌的敏感度100.0%,特异度96.0%,阳性预测值20.5%,阴性预测值100.0%。结论应重视并及时进行北京市社区人群宫颈病变的早期筛查,薄层液基细胞学结合阴道镜活组织检查及病理学检查,对提高早期宫颈癌筛查的准确性效果明显。 相似文献
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M. Jesús Cerecedo Pérez Margarita Tovar Bobo Aurora Rozadilla Arias 《Atencion primaria / Sociedad Espa?ola de Medicina de Familia y Comunitaria》2013,45(10):536-540
The power of medicine has lately enhanced the idea of medicalizing any aspects of life that can be perceived as medical problems. Medicine sometimes creates false needs and there is nowadays an increasing number of situations are medicalized with the pretext of treating fake diseases such as spring fatigue, shyness o natural biological processes like menopause.Despite the better life conditions, we now attend more people that complain about discomfort that may have more to do with «feeling sick» than with authentic disease. There is an endless list: sadness, hyperactive children, anorexia, bulimia, vigorexia or problematic teenagers, amongst others. In this article we revise some interventions that, contribute to promote these situations also from the own doctor's office. Everyday adversity acquires today the status of disease, hence the remarkable increase in these consultations in the diverse sanitary services. 相似文献
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Tomas Jose M. Caycho-Rodríguez Tomás Ventura-León José Sancho Patricia García Cirilo H. Arias Walter L. 《Journal of cross-cultural gerontology》2021,36(4):431-444
Journal of Cross-Cultural Gerontology - Although the Brief Resilient Coping Scale (BRCS) has been validated in some European and American countries, there are no studies that evaluate its factorial... 相似文献
49.
Finn Akerström MBChB Alberto Puchol MD Marta Pachón MD Cristina Martín‐Sierra MD Luis Rodíguez‐Padial MD PhD Miguel A. Arias MD PhD 《Pacing and clinical electrophysiology : PACE》2018,41(10):1362-1364
A 16‐year‐old male presented with an orthodromic atrioventricular reentrant tachycardia over a concealed parahisian accessory pathway (AP). Cryoablation of the AP resulted in transient manifestation of a fully preexcited sinus rhythm of parahisian AP morphology. Potential causes for the paradoxical preexcitation include inadvertent atrioventricular nodal block, sourse‐sink mismatch, as well as the activation of a dormant AP capable of anterograde conduction. 相似文献
50.
Arias Ivonne Herrera Daniel Bautista-Molano Wilson Bello-Gualtero Juan Manuel De Avila Juliette Salas-Cuestas Fabián Romero-Sánchez Consuelo 《Clinical rheumatology》2021,40(4):1343-1351
Clinical Rheumatology - The evidence shows that previous infection with enteric pathogens is a requirement to develop pSpA. Based on our previous results, variances on regulation of SIgA might... 相似文献