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排序方式: 共有1302条查询结果,搜索用时 15 毫秒
1.
T Uno M Takamatsu Y Inoue Y Kawahata K Iuchi G Tsukamoto 《Journal of medicinal chemistry》1987,30(12):2163-2169
A series of 6-fluoro- and 6,8-difluoro-7-(azole substituted)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids were prepared. Structure-activity relationship studies indicated that the antibacterial potency was better when the 6,8-substituents were fluorine atoms and the 7-substituent was either 1-imidazolyl, 20, or 4-methyl-1-imidazolyl, 25. From the results of studies on pharmacokinetic profile and toxicity, 20 and 25 were found to possess excellent antibacterial activities and to show high blood levels after oral administration to mice with low toxicity. 相似文献
2.
Yutaka Ejima Yoko Hasegawa Satoru Sanada Noriyuki Miyama Ryo Hatano Tomohiro Arata Michiko Suzuki Itsuro Kazama Akira Sato Susumu Satomi Wataru Hida Mitsunobu Matsubara 《Hypertension research》2006,29(4):261-267
Since the prevalence and clinical characteristics of young-onset hypertension are still to be elucidated, we performed targeted-screening at an annual university health check-up for two consecutive years. Out of 16,464 subjects in 2003 and 17,032 in 2004 that were aged less than 30 years, 22 and 26 students (all males) exhibited high blood pressure (BP), respectively, on three occasions during casual BP measurements at the Tohoku University Health Center (systolic and diastolic BP of 140 and/or 90 mmHg or greater, respectively). These students were asked to measure their BP at home, and 9 subjects in total were diagnosed as having essential hypertension (EH). The remaining students were diagnosed as having white coat hypertension (WCH). In 8 out of 9 EH students, their father and/or mother had also been treated with antihypertensive medication. Adjustment by attendance ratio for each BP measurement suggested that the incidence of EH was around 0.1% and that of hypertension (EH and WCH) was around 0.5% in university students aged less than 25 years, since most of the subjects and hypertensive students were between 18 and 24 years old. Body mass index of the EH, which was more than 25 kg/m2 (overweight), was significantly higher than that with WCH. In conclusion, the combination of repeated casual BP measurements and home BP effectively identified young-onset EH. The clinical parameters indicated that male gender, genetic background, and excessive weight were risk factors for young-onset hypertension. 相似文献
3.
Takashi Oono Yutaka Fujiwara Toshiko Yoshioka Jir Arata 《The Journal of dermatology》1997,24(10):626-629
We investigated prolidase activity in samples derived from wound fluid as well as blister fluid. Prolidase activity was elevated in fluid samples collected from wounds over the levels in sera collected from patients with chronic wounds (P<0.05). Prolidase activity was also present in samples taken from blister diseases. However, prolidase activity in blister fluid was not higher than that in sera collected from patients with blister diseases. Our results indicate that prolidase may play a role in wound healing. 相似文献
4.
- 1) The prolidase (Pd) and prolinase (Pn) activities of cultured skin fibroblasts derived from two prolidase-deficient sisters, the elder with typical clinical manifestations [symptom (+)] and the younger with only slight clinical manifestations [symptom (–)] were examined biochemically. Pd activity against several substrates other than Gly-Pro were present to some degree in both sisters. There were no detectable differences in Pd activity between the symptom (+) patient and the symptom (–) sister. Pn activity seemed to be increased in both. The lower Pn activity found against Pro-Gly as compared with those against other substrates indicates that Pro-Gly, which has been used for Pn assays in most previous reports, may not be the best substrate for this test. Pd derived from control fibroblasts was activated by Mn2+ against all substrates tested in this experiment. Cu2+, Hg2+, Cd2+ and Zn2+ remarkably inhibited enzyme activity, Co2+ slightly inhibited it, and neither Mg2+ nor Fe2+ had any remarkable effect. The Pd derived from the prolidase-deficient patients was also activated by Mn2+. This Pd seemed to be more inhibited by Co2+ than was the control. However, we found no remarkable differences between the two patients.
- 2) We also studied Pd and Pn activities in rat skin and blood during wound healing. Pd and Pn activities adjacent to the wound increased in parallel with fibroblast proliferation. Pd activity was also detected in an extract of newborn mouse epidermis.
5.
Huh WK Oono T Shirafuji Y Akiyama H Arata J Sakaguchi M Huh NH Iwatsuki K 《Journal of molecular medicine (Berlin, Germany)》2002,80(10):678-684
Defensins are cationic antimicrobial peptides with a broad spectrum. Recently human beta-defensin 2 (hBD-2) has been isolated from psoriatic skin; however, its exact localization and fate have not been fully understood. We studied the distribution pattern of hBD-2 in skin tissues of psoriasis and other inflammatory skin diseases. In the upper spinous and granular layer of psoriasis vulgaris hBD-2 was present in the cytoplasm. In the horny layer the positive signals were in a basket-weave pattern, indicating possible accumulation of hBD-2 in the intercellular space. The similar pattern of hBD-2 distribution was observed in the lesions of nummular eczema and atopic dermatitis. hBD-2 was not detected in the section of normal elbow and knee skin. When isolated psoriatic scales were stained, hBD-2 was detected in a wrapping paper-like distribution pattern surrounding the corneocytes. In horny layer of psoriatic skin hBD-2 was closely associated or colocalized with elafin, which is known to be in extracellular space, as demonstrated by double staining. Western blot analysis using cultured human keratinocytes detected hBD-2 with an expected size in the conditioned medium and in the cell lysates when stimulated with 5% FCS or IL-alpha. These results indicate that hBD-2 was synthesized and remained in cytoplasm in the upper spinous and granular layer, and then secreted into intercellular space in the horny layer. This dynamic change in hBD-2 distribution in epidermis is certainly relevant to function as an innate host defense mechanism against invading micro-organisms. 相似文献
6.
Saika T Tsushima T Nasu Y Arata R Kaku H Akebi N Kusaka N Kumon H 《Acta medica Okayama》2003,57(6):293-297
The aim of this study was to reveal the clinical features of anterior urethral recurrence in patients with superficial bladder cancer, and to determine the appropriate treatment. Three hundred and three patients with superficial bladder cancer, who were newly diagnosed and initially treated conservatively in our hospital between 1965 and 1990, were followed for at least 5 years and their clinical outcomes were analyzed. Clinical factors, including anterior urethral recurrence, were evaluated statistically regarding tumor progression. Eight patients (2.6%) had anterior urethral recurrence following superficial bladder cancer. Twenty-four patients (7.9%) had tumor progression and 149 (49.2%) had tumor recurrence. In a multivariate analysis using a logistic model, anterior urethral recurrence was the most important factor, followed by histological grade. Four of 5 patients who were treated for anterior urethral recurrent tumors by transurethral resection showed progression and died of the cancer within one year. Two of the remaining three patients who underwent radical cysto-urethrectomy at the time of anterior urethral recurrence survived. Anterior urethral recurrence following superficial bladder cancer is a predictor for rapid subsequent malignant progression. Once there is anterior urethral recurrence, radical intensive therapy, including radical cysto-urethrectomy, should be carried out immediately. 相似文献
7.
Akiko Arata H. Onimaru Ikuo Homma 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1998,119(4):399-408
We analysed the modulation of respiratory neurons by adrenaline or noradrenaline (NA) in a newborn rat brainstem-spinal cord
preparation. Adrenaline or NA caused a dose-dependent depression of the respiratory rhythm and induced C4 spinal tonic discharges.
The inhibitory effect of adrenaline (ED50=0.5 μM) on the respiratory rhythm was stronger than NA (ED50=5 μM). The adrenaline respiratory rhythm depression was partially blocked by the α1-antagonist prazosin or by the α2-antagonist yohimbine. The C4 tonic discharge elicited by adrenaline was blocked by the α1-antagonist prazosin. The direct effects of adrenaline on pre-inspiratory (Pre-I) neurons were examined in a synaptic blockade
solution (low Ca), and fifty-six percent of Pre-I neurons were found to continue firing. In low-Ca solution, Pre-I neurons
were excited (n=29 of 39) or depressed (n=5 of 39) by adrenaline, and excited by α1-agonist phenylephrine or depressed by α2-agonist clonidine. These results suggest that the respiratory rhythm depression under intact network conditions is mediated
by some other inhibitory system. The inhibitory effect of adrenaline on the respiratory rhythm was partially blocked by the
GABAA-antagonists bicuculline or picrotoxin, but not by the GABAB-antagonist phaclofen. The present results suggest that: (1) respiratory rhythm generation is more sensitive to adrenaline
than NA through α-adrenergic action of adrenaline; (2) the activity of Pre-I neurons could be directly regulated by excitation
via α1-receptors and inhibition via α2-receptors; and (3) the depression of the respiratory rhythm by adrenaline is partly mediated by GABAAergic neurons.
Received: 8 April 1997 / Accepted: 6 October 1997 相似文献
8.
Nakamichi I Takakuwa T Tanio Y Iuchi K Aozasa K 《Virchows Archiv : an international journal of pathology》2005,447(5):888-891
Pyothorax-associated lymphoma (PAL) is a B-cell lymphoma which develops in the pleural cavity of patients with an over-20-year
history of pyothorax. Aberrant expression of surface antigens is occassional in PAL, although genotype is not fully investigated.
We report here a PAL with dual genotype, i.e., simultaneous immunoglobin (Ig) and T-cell receptor (TcR) gene rearrangement.
An 82-year-old woman with pain on the left side of the chest was admitted. She had been suffering from pyothorax after artificial
pneumothorax for treatment of tuberculosis of the pulmonary when she was 18 years old. The mass that was confined to the left
pleural cavity affected by pyothorax was biopsied and histologically diagnosed as diffuse large cell lymphoma. The tumor cells
were positive for CD20, CD16, and TIA-1 but negative for CD79a, CD45RO, CD43, CD3, and CD56. Surface antigen expression was
further investigated in cultured cells, showing that the cultured cells did not express representative B-cell markers, except
for CD20, as well as T-cell markers, but were positive for CD16, CD30, and CD103. Southern blotting revealed the monoclonally
rearranged bands of both Ig heavy chain and TcR gene. The patients died of tumors 14 months after admission. Aberrant genotype
and immunophenotype of PAL cells is discussed in reviewing the pertinent literature. 相似文献
9.
K Sawamura T Mori K Iuchi H Tada Y E Lee T Mizuta A Ichimiya 《Nihon Geka Gakkai zasshi》1985,86(9):1064-1066
A new operative method named as "Extraperiosteal air plombage" against chronic empyema were performed to 80 patients and its cure rate by the first operation was 93.8% which is a good and high rate. Know-how to perform the operation without failure is (1) to complete the excoriation of the pleural debris, (2) to seal completely the leakage such as bronchiolar fistula, (3) to perform the extraperiosteal abbration rather over much to attach the lung to the muscle layer, (4) to close the chest wall completely, and (5) to wash out thoroughly the extraperiosteal cavity with brush and enough saline solution and to use the effective antibiotica. 相似文献
10.
Provenzale JM Arata MA Turkington TG McLendon RE Coleman RE 《AJR. American journal of roentgenology》1999,172(4):1103-1107
OBJECTIVE: The purpose of this study was to correlate 18F-fluorodeoxyglucose positron emission tomography (PET) and MR imaging features of cerebral gangliogliomas before and after PET-MR image registration. CONCLUSION: After registration of PET and MR images, all six gangliogliomas in our series were shown to have heterogeneous metabolic activity. Areas of hypermetabolic activity were seen in all lesions. In five of the six cases, PET-MR image registration provided information regarding tumor metabolism that was not available on nonregistered hard-copy examinations. 相似文献