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61.
Kumral Ergun Cagli Dursun Aras Serkan Topaloglu Bilal Geyik Selime Ayaz Goksel Cagirci Halil Lutfi Kisacik Sule Korkmaz 《Heart and vessels》2010,25(2):131-137
This study aimed to determine whether plasma levels of tumor necrosis factor-α (TNF-α) and soluble TNF receptor (sTNF-R) increases
in rheumatic mitral stenosis (MS) patients with sinus rhythm and to examine the effect of percutaneous mitral balloon valvuloplasty
(PMBV) on these parameters. Twenty-six patients with MS and sinus rhythm (study group, 20 female, mean age 33 ± 8 years),
who were scheduled for PMBV, and a well-matched control group consisting of 21 healthy volunteers (15 female, mean age 35
± 6 years) were enrolled in the study. Tumor necrosis factor-α and sTNF-R levels were compared between study patients and
controls, and between peripheral and left atrium (LA) blood. Changes in TNF α and sTNF-R levels 24 h and 4 weeks after PMBV
were analyzed. Significantly higher baseline TNF-α and sTNF-R levels were noted in the study group. In the study group, TNF-α
and its receptors were also found to be higher in LA blood than in baseline peripheral blood. After PMBV, mitral valve area
(MVA) increased and transmitral pressure gradient decreased significantly. At the 24th hour after PMBV, the TNF-α level decreased
from 29.61 ± 12.22 pg/ml to 22.42 ± 8.81 pg/ml (P < 0.0001) and at the 4th week, from 22.42 ± 8.81 pg/ml to 18.92 ± 7.37 pg/ml (P < 0.0001). Similar reductions were observed in the sTNF-R level. Regression analysis between the difference in sTNF-R level
measured 24 h after and before PMBV and the difference in MVA measured 24 h after and before PMBV showed a significant direct
relationship between these variables. This study suggests that isolated rheumatic MS without atrial fibrillation is accompanied
by increased TNF-α and sTNF-R level. The successful PMBV establishes a significant reduction in TNF-α and its receptors, probably
due to improved postprocedural hemodynamic parameters. 相似文献
62.
The myocardium preferentially oxidizes free fatty acids for energy production. However, the dependency of this metabolic pathway on oxygen makes this process vulnerable to ischemia. The energy requirements of the myocardium are subsequently met by the oxidation of carbohydrates, particularly glucose. Recovery of fatty acid metabolism lags behind restoration of perfusion, resulting in the phenomenon of metabolic stunning. This decrease of fatty acid utilization following ischemia can be imaged with fatty acid radiotracers, particularly beta-Methyl-p-(123)I-iodophenyl pentadecanoic acid (BMIPP), which demonstrates markedly limited metabolism via beta-oxidation, resulting in prolonged retention in the cardiomyocyte. Thus, in patients presenting with chest pain and no prior myocardial infarction, abnormal BMIPP uptake at rest reflects metabolic alteration caused by the preceding ischemia, also termed ischemic memory. 相似文献
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Kumral Ergun Cagli Umit Guray MD ?brahim Akp?nar MD Nihat Sen MD Dursun Aras MD Serkan Topaloglu MD 《Journal of electrocardiology》2010,43(1):68
Despite their proven efficacy at reducing mortality in selected patients, implantable cardioverter-defibrillators have some proarrhythmic effects. In this report, we present a case of a patient with recurrent ventricular tachycardia degeneration to ventricular fibrillation by appropriate low-energy implantable cardioverter-defibrillator shocks. 相似文献
65.
Canda AE Sevinc AI Kocdor MA Canda T Balci P Saydam S Harmancioglu O 《Clinical breast cancer》2007,7(8):638-643
Breast cancer is the most common malignancy in women. However, metastases to the breast from nonmammary malignant neoplasms are rare and were detected at a rate of 0.28% in our series. Clinical and pathologic findings in 5 cases of metastatic tumors (malign mesenchymal tumor, squamous cell carcinoma of the tongue, non-Hodgkin lymphoma, and Sézary syndrome) in the breast are presented and discussed with respect to the literature. Detailed clinical history and a multidisciplinary approach are useful in establishing correct diagnosis and preventing unnecessary radical surgery. 相似文献
66.
Luis AL Bret M Cuesta E Aras RM Xiaomei L Encinas JL Martinez L Tovar JA 《Pediatric surgery international》2011,27(2):175-180
Background/aim
Infants and rats with congenital diaphragmatic hernia (CDH) have malformations of the heart and the great arteries caused by neural crest (NC) dysregulation during embryogenesis. Abnormally narrow jugular veins have been found in babies during cannulation for ECMO. However, the venous system has not been examined in depth so far. We hypothesized that abnormal patterning and/or size of the thoracic veins could occur in rats with CDH. This hypothesis was tested by microscopic magnetic resonance imaging (MMRI), a high-resolution tool able to detect subtle changes of vessels in small animals. 相似文献67.
Tuğcu V Taşci AI Ozbek E Aras B Verim L Gürkan L 《International urology and nephrology》2008,40(2):269-275
Objective To investigate whether stone dimension is a restrictive factor for ureterorenoscopic procedures.
Materials and methods A group of 416 patients who had undergone ureterorenoscopic pneumatic lithotripsy (URS-PL) for lower ureteral stones between
January 1999 and June 2006 in our clinic had been evaluated retrospectively. Two hundred and seventy (270, 64.9%) patients
were men and 146 (35.1%) were women. The mean age of the patients was 36.61 (±12.43) years. Patients were grouped according
to stone dimension; 193 patients with stones smaller than 1 cm being group 1 and 223 patients with stones ≥1 cm in dimension
being group 2. Stone-free rate, operative time and rate of complications of the groups were compared. Pearson’s correlation
test, χ2 test, Fischer’s exact test and Student’s t-test were used for the statistical analysis. The p value was accepted as being meaningful if p < 0.05.
Results For group 1, the mean operative time was 39.19 (±18.33) min. Proximal stone migration in five and false passage formation
in three patients was observed. Three patients were stone-free after a second session of URS-PL. The cumulative stone-free
rate was 97.4% (188/193). For group 2, the mean operative time was 48.5 (±11.31) min. About 208 (93.27%) patients were stone-free
after the first session and an additional eight patients became stone-free after the second session of URS-PL. False passage,
ureteral perforation, ureteral avulsion and stricture were observed in four, six, one and one patients, respectively. No proximal
stone migration was observed. The cumulative stone-free rate was 96.86% (216/223).
Conclusions The effectiveness of ureterorenoscopy (URS) in the treatment of distal ureteral stones was independent of stone dimension.
However, the operative time was longer and the rate of perforation was higher in stones with a diameter ≥1 cm. On the other
hand, the migration rate was higher in stones <1 cm in diameter. Generally speaking, there was no meaningful effect of stone
dimension on complication rates. 相似文献
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