全文获取类型
收费全文 | 1526篇 |
免费 | 93篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 104篇 |
妇产科学 | 31篇 |
基础医学 | 233篇 |
口腔科学 | 20篇 |
临床医学 | 114篇 |
内科学 | 288篇 |
皮肤病学 | 19篇 |
神经病学 | 155篇 |
特种医学 | 44篇 |
外科学 | 154篇 |
综合类 | 18篇 |
一般理论 | 1篇 |
预防医学 | 170篇 |
眼科学 | 23篇 |
药学 | 128篇 |
中国医学 | 3篇 |
肿瘤学 | 89篇 |
出版年
2024年 | 2篇 |
2023年 | 15篇 |
2022年 | 24篇 |
2021年 | 65篇 |
2020年 | 46篇 |
2019年 | 44篇 |
2018年 | 62篇 |
2017年 | 42篇 |
2016年 | 52篇 |
2015年 | 45篇 |
2014年 | 58篇 |
2013年 | 93篇 |
2012年 | 131篇 |
2011年 | 112篇 |
2010年 | 76篇 |
2009年 | 55篇 |
2008年 | 104篇 |
2007年 | 93篇 |
2006年 | 77篇 |
2005年 | 72篇 |
2004年 | 76篇 |
2003年 | 62篇 |
2002年 | 67篇 |
2001年 | 9篇 |
2000年 | 13篇 |
1999年 | 13篇 |
1998年 | 11篇 |
1997年 | 10篇 |
1996年 | 6篇 |
1995年 | 8篇 |
1994年 | 7篇 |
1993年 | 4篇 |
1992年 | 8篇 |
1991年 | 15篇 |
1990年 | 5篇 |
1989年 | 8篇 |
1988年 | 5篇 |
1987年 | 4篇 |
1986年 | 7篇 |
1985年 | 8篇 |
1984年 | 2篇 |
1983年 | 5篇 |
1982年 | 2篇 |
1980年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有1625条查询结果,搜索用时 31 毫秒
51.
52.
Carola Gianni Domenico G. Della Rocca Jun Kim Anu Sahore Salwan Andrea Natale Amin Al‐Ahmad 《Journal of cardiovascular electrophysiology》2020,31(8):2253-2256
A 72‐year‐old woman with a history of paroxysmal atrial fibrillation (AF) and sinus node dysfunction is seen in clinic for routine follow‐up. 相似文献
53.
Anu Balakrishnan Rohit Aggarwal Vikas Agarwal Latika Gupta 《International journal of rheumatic diseases》2020,23(9):1126-1135
Inclusion body myositis is a rare sporadic inflammatory‐degenerative myopathy of the elderly. Despite being the commonest type of acquired myopathy after the age of 50, misdiagnosis is extremely common. The most frequent hurdle in identifying new cases is the wrong diagnosis of polymyositis or motor neuron disease. Novel insights into pathogenic mechanisms have heralded the quest for newer therapeutics as well as drug repurposing in this otherwise progressive disorder. 相似文献
54.
55.
Lieber SB Redberg RF Blumenthal RS Gandhi A Robb KJ Mora S 《The American journal of cardiology》2012,109(12):1754-1760
Increased physical activity (PA) is associated with improvement of cardiac risk factors and prevention of cardiovascular disease, yet many women remain sedentary. With rising Internet use, Web-based interventions provide an alternative to improve PA, but their effectiveness for change in PA and quality of life (QOL) in a real-world setting is unknown. Participants were United States women ≥18 years old who received 12 weekly PA modules and completed surveys on PA, QOL, and readiness for PA at registration (registration cohort, n = 3,796) or registration and 12 weeks (evaluation cohort, n = 892). QOL was assessed with a modified Short Form-36 with subscores for energy and well-being. Participants showed significant (p <0.001) favorable changes in PA (baseline, median 240 kcal/week, interquartile range 62 to 667; 12 weeks, 343 kcal/week, 131 to 828), stage of readiness for PA, and body mass index (baseline, 29.3 kg/m(2), 24.9 to 34.7; 12 weeks, 28.9 kg/m(2), 24.6 to 34.2). Significant improvements (p <0.0001) were also found in composite scores for energy and well-being. Compliance with PA guideline recommendations increased from 15.8% to 21.4%. Program weeks completed (p = 0.03), energy (p = 0.04), and well-being (p = 0.002) were significantly associated with achieving guideline compliance. In women reporting no PA at baseline (n = 88), program participation resulted in 54.6% achieving some PA and another 9.1% achieving total compliance with recommendations. In conclusion, in this national cohort of women, a 12-week Web-based intervention improved PA and QOL measurements, resulting in higher short-term PA guideline compliance and better QOL. Increasing use of this simple Web-based tool could improve PA and promote disease prevention. 相似文献
56.
Inflammaging refers to a low-grade pro-inflammatory phenotype which accompanies aging in mammals. The aging process is associated with a decline in autophagic capacity which impairs cellular housekeeping, leading to protein aggregation and accumulation of dysfunctional mitochondria which provoke reactive oxygen species (ROS) production and oxidative stress. Recent studies have clearly indicated that the ROS production induced by damaged mitochondria can stimulate intracellular danger-sensing multiprotein platforms called inflammasomes. Nod-like receptor 3 (NLRP3) can be activated by many danger signals, e.g. ROS, cathepsin B released from destabilized lysosomes and aggregated proteins, all of which evoke cellular stress and are involved in the aging process. NLRP3 activation is also enhanced in many age-related diseases, e.g. atherosclerosis, obesity and type 2 diabetes. NLRP3 activates inflammatory caspases, mostly caspase-1, which cleave the inactive precursors of IL-1β and IL-18 and stimulate their secretion. Consequently, these cytokines provoke inflammatory responses and accelerate the aging process by inhibiting autophagy. In conclusion, inhibition of autophagic capacity with aging generates the inflammaging condition via the activation of inflammasomes, in particular NLRP3. We will provide here a perspective on the current research of the ROS-dependent activation of inflammasomes triggered by the decline in autophagic cleansing of dysfunctional mitochondria. 相似文献
57.
Naggie S Osinusi A Katsounas A Lempicki R Herrmann E Thompson AJ Clark PJ Patel K Muir AJ McHutchison JG Schlaak JF Trippler M Shivakumar B Masur H Polis MA Kottilil S 《Hepatology (Baltimore, Md.)》2012,56(2):444-454
Recent studies have shown that a single-nucleotide polymorphism upstream of the interleukin-28B (IL28B) gene plays a major role in predicting therapeutic response in hepatitis C virus (HCV)-infected patients treated with pegylated interferon (PEG-IFN)/ribavirin. We sought to investigate the mechanism of the IL28B polymorphism, specifically as it relates to early HCV viral kinetics, IFN pharmacokinetics, IFN pharmacodynamics, and gene expression profiles. Two prospective cohorts (human immunodeficiency virus [HIV]/HCV-coinfected and HCV-monoinfected) completing treatment with IFN/ribavirin were enrolled. Patients were genotyped at the polymorphic site rs12979860. In the HIV/HCV cohort, frequent serum sampling was completed for HCV RNA and IFN levels. DNA microarray of peripheral blood mononuclear cells and individual expression of IFN-stimulated genes (ISGs) were quantified on IFN therapy. The IL28B-favorable (CC) genotype was associated with improved therapeutic response compared with unfavorable (CT or TT) genotypes. Patients with a favorable genotype had greater first- and second-phase viral kinetics (P = 0.004 and P = 0.036, respectively), IFN maximum antiviral efficiency (P = 0.007) and infected cell death loss (P = 0.009) compared with unfavorable genotypes. Functional annotation analysis of DNA microarray data was consistent with depressed innate immune function, particularly of natural killer cells, from patients with unfavorable genotypes (P <0.004). Induction of innate immunity genes was also lower in unfavorable genotypes. ISG expression at baseline and induction with IFN was independent of IL28B genotype. CONCLUSION: Carriers of the IL28B-favorable genotype were more likely to have superior innate immune response to IFN therapy compared with unfavorable genotypes, suggesting that the unfavorable genotype has aberrant baseline induction of innate immune response pathways resulting in impaired virologic response. IL28B genotype is associated with more rapid viral kinetics and improved treatment response outcomes independent of ISG expression. 相似文献
58.
Miriam C. Boesch Oliver Wendt Anu Subramanian Ning Hsu 《Research in autism spectrum disorders》2013,7(3):480-493
An experimental, single-subject research study investigated the comparative efficacy of the Picture Exchange Communication System (PECS) versus a speech-generating device (SGD) in developing requesting skills for three elementary-age children with severe autism and little to no functional speech. Results demonstrated increases in requesting behavior for all participants across intervention phases with both augmentative and alternative communication (AAC) intervention strategies; however, difficulties were observed with picture discrimination. The Wilcoxon signed pair test did not reveal significant differences between PECS and the SGD for any participant. Findings suggest PECS and SGD are equally appropriate for developing initial requesting skills. Based on the current findings, successful implementation of either AAC strategy is achievable when appropriate instructional strategies are used. 相似文献
59.
60.