全文获取类型
收费全文 | 46164篇 |
免费 | 2377篇 |
国内免费 | 367篇 |
专业分类
耳鼻咽喉 | 475篇 |
儿科学 | 870篇 |
妇产科学 | 1332篇 |
基础医学 | 5523篇 |
口腔科学 | 1740篇 |
临床医学 | 3553篇 |
内科学 | 12912篇 |
皮肤病学 | 967篇 |
神经病学 | 4030篇 |
特种医学 | 1213篇 |
外科学 | 6978篇 |
综合类 | 186篇 |
一般理论 | 9篇 |
预防医学 | 2626篇 |
眼科学 | 727篇 |
药学 | 2522篇 |
中国医学 | 117篇 |
肿瘤学 | 3128篇 |
出版年
2024年 | 41篇 |
2023年 | 325篇 |
2022年 | 786篇 |
2021年 | 1502篇 |
2020年 | 812篇 |
2019年 | 1160篇 |
2018年 | 1601篇 |
2017年 | 1045篇 |
2016年 | 1140篇 |
2015年 | 1333篇 |
2014年 | 1827篇 |
2013年 | 2418篇 |
2012年 | 3696篇 |
2011年 | 3641篇 |
2010年 | 2065篇 |
2009年 | 1793篇 |
2008年 | 3094篇 |
2007年 | 3209篇 |
2006年 | 2979篇 |
2005年 | 2964篇 |
2004年 | 2688篇 |
2003年 | 2402篇 |
2002年 | 2134篇 |
2001年 | 321篇 |
2000年 | 242篇 |
1999年 | 344篇 |
1998年 | 389篇 |
1997年 | 332篇 |
1996年 | 290篇 |
1995年 | 286篇 |
1994年 | 228篇 |
1993年 | 170篇 |
1992年 | 164篇 |
1991年 | 125篇 |
1990年 | 123篇 |
1989年 | 96篇 |
1988年 | 80篇 |
1987年 | 66篇 |
1986年 | 83篇 |
1985年 | 77篇 |
1984年 | 79篇 |
1983年 | 67篇 |
1982年 | 95篇 |
1981年 | 74篇 |
1980年 | 75篇 |
1979年 | 41篇 |
1978年 | 52篇 |
1977年 | 37篇 |
1976年 | 40篇 |
1975年 | 34篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
José I. Bilbao Manuel Ruza Jesús M. Longo Francisco Mansilla Antonio Picardi Vanessa de Villa Fernando Pardo Jesús Sola Jorge Quiroga 《Cardiovascular and interventional radiology》1994,17(4):210-213
Posttransplant lymphoproliferative disorders are infrequent tumors related to chronic immunosuppressive therapy. We present a liver transplant recipient who developed such a tumor in the porta hepatis that provoked obstruction of the entire portal triad. Treatment consisted of systemic chemotherapy, percutaneous dilatation, and placement of Wallstent endoprostheses across both biliary and portal vein stenoses. The patient died 3 weeks later of pneumonia and sepsis. At necropsy, the tumor was completely necrosed and the prostheses in both the common bile duct and the portal vein were patent. 相似文献
82.
J A Barrabés Riu C Tolosa Vilella J Ordi Ros G Permanyer Miralda A Salas Caudevilla 《Revista espa?ola de cardiología》1991,44(6):411-413
Cholesterol embolism is a rare but serious complication of heart catheterization. We report a patient in whom cholesterol embolization syndrome developed after coronary angioplasty complicated by an acute myocardial infarction which was treated with streptokinase and heparin. The clinical outcome was satisfactory. Cholesterol embolism occurrence might have been precipitated in this patient by thrombolytic and anticoagulant therapy. 相似文献
83.
Mutations Affecting the Rossman Fold of Isoleucyl-tRNA Synthetase Are Correlated with Low-Level Mupirocin Resistance in Staphylococcus aureus
下载免费PDF全文
![点击此处可从《Antimicrobial agents and chemotherapy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Martin Antonio Neil McFerran Mark J. Pallen 《Antimicrobial agents and chemotherapy》2002,46(2):438-442
The isoleucyl-tRNA synthetase (ileS) gene was sequenced in toto from 9 and in part from 31 Staphylococcus aureus strains with various degrees of susceptibility to mupirocin. All strains for which the mupirocin MIC was greater than 8 microg/ml contained point mutations affecting the Rossman fold via Val-to-Phe changes at either residue 588 (V588F) or residue 631 (V631F). The importance of the V588F mutation was confirmed by an allele-specific PCR survey of 32 additional strains. Additional mutations of uncertain significance were found in residues clustered on the surface of the IleS protein. 相似文献
84.
Antonio F. Govoni M.D 《Clinical imaging》1992,16(4):285
85.
Ana Sánchez-Romero Israel Oliver David Costa Albina Orduña Javier Lacueva Francisco Pérez-Vicente Antonio Arroyo Rafael Calpena 《Clinical & translational oncology》2006,8(4):294-295
Lung cancer is the most prevalent malignancy in western countries and most of the patients present at advanced stages, but
single splenic metastasis is exceptional instead. We report on a case of a seventy-three-year old male presenting with non-hemoptoic
productive cough, constitutional syndrome and pain in the left lower quadrant. Physical examination and complementary radiological
and hystologycal procedures revealed the presence of an adenocarcinoma of the left lung with probable splenic metastasis.
The patient underwent splenectomy, which confirmed the diagnose of splenic metastasis of lung adenocarcinoma and, secondly,
lung resection was performed. Topics about lung cancer metastasis are discussed. 相似文献
86.
Alfonso Fasano Antonio E Elia Arianna Guidubaldi Pietro A Tonali Anna Rita Bentivoglio 《Movement disorders》2007,22(4):564-566
We report a case of cervical dystonia occurring in a 33-year-old without personal history of movement disorder but with family history of essential tremor, primigravid, primiparous woman at 1 weeks' amenorrhea, resolved completely after delivery in the course of 3 months. Dystonia never recurred in the following 5 years. Several neurological disorders are known to occur or worsen during pregnancy. As far as we know, this is the second reported case of dystonia occurring during pregnancy, thus confirming that dystonia gravidarum represents a new entity and should be considered in women of reproductive age affected by dystonia, especially when presenting with rapid-onset cervical dystonia. 相似文献
87.
Julieta Ramos-Loyo Andrés Antonio Gonzalez-Garrido Claudia Amezcua Miguel A Guevara 《International journal of psychophysiology》2004,54(3):251-262
In spite of previous reports on the relationship between ongoing EEG and ERPs, there remains a lack of agreement on the nature of their nexuses. The aim of the present study was to evaluate the relationship between resting EEG and the ERP components in two groups of healthy subjects with different levels of performance in a highly demanding selective visual attention task. Young adults were classified according to the amount of their correct responses in the task, into high (HP; averaged hits (AH): 86%) and low performance groups (LP; AH: 59%). EEG was recorded during rest, prior to task performance and absolute (AP) and relative power (RP), as well as inter- (rTER) and intrahemispheric (rTRA) correlation were calculated. ERPs during task performance were also obtained and their amplitude and latency measures were assessed. Results showed that individuals with better behavioral performance had a higher synchronization between both hemispheres during rest as well as higher amplitude and shorter latencies of N2 and P3. Principal Component Analysis revealed that alpha2 AP and RP were inversely related to P2 and N2 latency. Higher values of alpha1 and alpha2 rTER were clustered with higher P3 amplitude and shorter reaction time. In conclusion, the differences in the cortical organization of HP and LP at rest (EEG) seem to be associated to the way the brain reacts during information processing (ERPs). 相似文献
88.
Erich Stoelben Holger Harpering Joerg Haberstroh Antonio di Filippo Eckhard Wellens 《European journal of cardio-thoracic surgery》2003,23(1):15-20
INTRODUCTION: The successful use of cryopreserved tracheal allografts in canine models suggests their use in humans. The grade of genetic difference, the mechanism of revascularisation and the method of cryopreservation are not clearly defined. The purpose of our study was to investigate the rejection of tracheal transplants in a standardised heterotopic rat model using different forms of cryopreservation. METHODS: Tracheae from Brown Norway rats were implanted into the omentum from Brown Norway rats or Lewis rats. We transplanted fresh isografts or allografts and pretreated isografts or allografts. Cryopreservation was performed in a medium containing 10% dimethyl sulphoxide at -80 degrees C for 28 days (I) or -196 degrees C for 84 days (II) or without medium at -80 degrees C for 28 days (III). The transplants were excised after 7 and 21 days, respectively. RESULTS: Histological examinations revealed normal structure and function of isografts after 21 days. In the cryopreserved isograft, the epithelium had disappeared and the tracheal lumen was partially obstructed by a non-compact fibrous tissue. In the fresh allografts, the epithelium was replaced by aggressive fibrous tissue, infiltrating the membranous part of the trachea and occluding the tracheal lumen. The cartilage was vital without any sign of rejection. In the cryopreserved allografts, the tracheal lumen was obstructed by dense fibrous tissue with an inflammatory reaction. The cartilage of cryopreserved allografts (II) and (III) had lost the nuclei corresponding to non-vital tissue. Only in the cryopreserved allografts (I) did we find nodular regeneration at the edges of the cartilaginous bow. CONCLUSIONS: The heterotopic transplantation model allows the study of the mechanisms leading to tracheal obstruction. Cryopreservation was found to have no clear advantage in reducing transplant immunogenicity. Cryopreservation leads to significant damage to the cartilage, the intensity of which is dependent on the mode of cryopreservation. 相似文献
89.
Paolo Mariotti Alfonso Fasano M Fiorella Contarino Giacomo Della Marca Marco Piastra Orazio Genovese Silvia Pulitanò Antonio Chiaretti Anna Rita Bentivoglio 《Movement disorders》2007,22(7):963-968
Status dystonicus (SD) is a life threatening disorder that develops in patients with both primary and secondary dystonia, characterized by acute worsening of symptoms with generalized and severe muscle contractions. To date, no information is available on the best way to treat this disorder. We review the previously described cases of SD and two new cases are reported, one of which occurring in a child with static encephalopathy, and the other one in a patient with pantothenate kinase-associated neurodegeneration. Both patients were admitted to an intensive care unit and treated with midazolam and propofol. This approach proved to be useful in the former while the progressive nature of the dystonia of the second patient required the combination of intrathecal baclofen infusion and bilateral pallidal deep brain stimulation. We believe that a rapid and aggressive approach is justified to avoid the great morbidity and mortality which characterize SD. Our experience, combined with the data available in the literature, might permit to establish the best strategies in managing this rare and severe condition. 相似文献
90.
Fumiaki Ikeno Tomoaki Hinohara Gregory C Robertson Mehrdad Rezaee Paul G Yock Bernhard Reimers Antonio Colombo Eberhard Grube John B Simpson 《Catheterization and cardiovascular interventions》2004,61(1):35-43
The use of directional coronary atherectomy (DCA) in current practice has been limited. The SilverHawk System is a newly developed plaque excision device that aims to overcome the drawbacks of prior DCA platforms. The device was evaluated in a porcine coronary model and in a series of patients. Procedural variables along with outcomes were reviewed. Quantitative angiography (QCA) was performed and excised tissue fragments were weighed and examined histologically. In porcine cases, pretreatment MLD increased from 0.51 +/- 0.26 to 2.36 +/- 0.59 mm postdebulking and 19.9 +/- 7.6 mg of tissue was retrieved. In human cases, pretreatment MLD increased from 0.8 +/- 0.4 to 2.2 +/- 0.5 mm postdebulking and 15.2 +/- 7.8 mg of tissue was retrieved without complications. These data show that the SilverHawk System may offer significant utility in treating a wide variety of complex coronary lesions. 相似文献