全文获取类型
收费全文 | 49802篇 |
免费 | 2541篇 |
国内免费 | 394篇 |
专业分类
耳鼻咽喉 | 499篇 |
儿科学 | 990篇 |
妇产科学 | 1408篇 |
基础医学 | 6011篇 |
口腔科学 | 1841篇 |
临床医学 | 3805篇 |
内科学 | 13546篇 |
皮肤病学 | 1009篇 |
神经病学 | 4287篇 |
特种医学 | 1391篇 |
外科学 | 7459篇 |
综合类 | 193篇 |
一般理论 | 9篇 |
预防医学 | 3012篇 |
眼科学 | 985篇 |
药学 | 2784篇 |
中国医学 | 119篇 |
肿瘤学 | 3389篇 |
出版年
2023年 | 320篇 |
2022年 | 673篇 |
2021年 | 1568篇 |
2020年 | 843篇 |
2019年 | 1210篇 |
2018年 | 1648篇 |
2017年 | 1104篇 |
2016年 | 1184篇 |
2015年 | 1414篇 |
2014年 | 1913篇 |
2013年 | 2507篇 |
2012年 | 3879篇 |
2011年 | 3834篇 |
2010年 | 2161篇 |
2009年 | 1869篇 |
2008年 | 3288篇 |
2007年 | 3401篇 |
2006年 | 3228篇 |
2005年 | 3186篇 |
2004年 | 2918篇 |
2003年 | 2612篇 |
2002年 | 2337篇 |
2001年 | 483篇 |
2000年 | 367篇 |
1999年 | 446篇 |
1998年 | 423篇 |
1997年 | 371篇 |
1996年 | 351篇 |
1995年 | 314篇 |
1994年 | 248篇 |
1993年 | 181篇 |
1992年 | 233篇 |
1991年 | 173篇 |
1990年 | 172篇 |
1989年 | 163篇 |
1988年 | 155篇 |
1987年 | 115篇 |
1986年 | 132篇 |
1985年 | 126篇 |
1984年 | 124篇 |
1983年 | 90篇 |
1982年 | 109篇 |
1981年 | 82篇 |
1980年 | 81篇 |
1979年 | 64篇 |
1978年 | 74篇 |
1977年 | 53篇 |
1976年 | 56篇 |
1974年 | 51篇 |
1973年 | 59篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
71.
Basilio Pispisa Mariano Venanzi Antonio Palleschi Maria D'Alagni 《Macromolecular chemistry and physics.》1995,196(9):2809-2825
The photophysics of protoporphyrin-naphthyl (P-N) pairs covalently and randomly bound to the ε-amino groups of the side-chains of poly(L -lysine) (PL) were investigated by steady-state and time-resolved fluorescence measurements. The results indicate that quenching of excited naphthalene (λex = 280 nm) chiefly occurs by interconversion to the triplet state when the polymeric matrix is in random coil (pH ≈ 7) and by intramolecular electron transfer from ground-state porphyrin, P → 1N*, when the polypeptide is in α-helical conformation (pH ≈ 11), the specific rate constant of the electron transfer being 3,1 · 107 s?1 (25°C). PNPL exhibits very little exciplex fluorescence, whatever the pH, suggesting both a reduced internal Brownian motion of the chromophores, owing to the amide bond in the substituted side-chains, and a relatively large average interprobe separation distance. This agrees with polarized fluorescence data and with the results of a conformational statistics analysis on the fully ordered PNPL, indicating that the average interchromophoric distance for which the electron transfer has the highest probability to occur is around 12 Å. The computational results allowed us to reproduce the experimental fluorescence decay curves and estimate the parameters governing the electron transfer process. Implications of these findings on the relaxation time of the heli-xcoil transition in PNPL are briefly discussed. 相似文献
72.
Jos Meseguer Antonio Lpez-Ruiz Alfonsa Garcí-Ayala 《Anatomical record (Hoboken, N.J. : 2007)》1995,241(3):303-309
Background: Head-kidney, considered the major fish lympho-haemopoietic tissue, consists of cells of the different haemopoietic series supported by a network of stromal cells whose morphofunctional properties have not been established. We report the ultrastructure and cytochemical features of the reticulo-endothelial stroma of the head-kidney from the seawater teleost gilthead seabream (Sparus aurata L.). Methods: Samples of head-kidney were processed for electron microscopic study. Some of the samples were incubated for acid and alkaline phosphatase, peroxidase, glucose-6-phosphatase, or ATPase. Results: The reticulo-endothelial stroma of gilthead seabream head-kidney consists of sinusoidal cells (endothelial and adventitial cells) and reticular cells (macrophage-type reticulum and fibroblast-like reticular cells). Transcytosis vesicles and rounded medium electron-dense granules were observed in the cytoplasm of the endothelial cells. The adventitial cells partially covered the outside surface of the endothelial cells and were joined by desmosomes. The macrophage-type reticulum cells were characterized by their cytoplasmic processes and acid phosphatase positive lysosomes. The fibroblast-like reticular cells were joined by desmosomes and formed an extensive network between the haemopoietic parenchyma. They were peroxidase negative and acid and alkaline phosphatase, glucose-6-phosphatase, β-glucuronidase, and ATPase positive. Conclusions: The ultrastructural and cytochemical features of the reticulo-endothelial stroma of the gilthead seabream head-kidney are similar to those of mammalian bone marrow, suggesting phylogenetic analogies between both tissues. © 1995 Wiley-Liss, Inc. 相似文献
73.
74.
H S Matloub C D Prevel J R Sanger N J Yousif C A Devine J Romano 《Annals of plastic surgery》1992,29(6):559-563
Several articles have been published that bring attention to the destructive potential of tire explosions. Although the severity of tire explosion injuries to the head and neck region is well established, only one previous article has reported injuries to the upper extremity. Fourteen patients with upper extremity tire explosion injuries have been treated by us from 1980 to 1988. Each injury was caused by single-piece wheel assemblies, as opposed to multipiece wheel assemblies, which have traditionally been associated with the injury. Three representative patient reports are discussed. Prevention of this injury can be achieved by increased public awareness, formal industrial safety training, tire servicing with dedicated equipment including restraining devices or barriers, complete evaluation of wheel/tire serviceability before tire mounting, separation of servicing of single and multipiece wheels, and complete tire deflation before servicing. 相似文献
75.
76.
Dr. Franco Zunino Brunella Barbieri Ornella Bellini Anna Maria Casazza Cristina Geroni Fernando Giuliani Antonio Ciana Giorgio Manzini Franco Quadrifoglio 《Investigational new drugs》1986,4(1):17-23
Summary The chromophore-modified derivative of doxorubicin, 4-demethyl-6-0-methyl-doxorubicin, has been tested for antitumor activity in a range of experimental murine tumor systems. In contrast to the inactive 6-0-methyl derivative of daunorubicin, 4-demethyl-6-0-methyl-doxorubicin provided antitumor effects comparable to that of the parent compound. In addition, detailed DNA-interaction studies showed that the doxorubicin derivative retains the ability to bind DNA by the intercalation mechanism. However, the binding affinity was appreciably reduced following structural modification in the anthraquinone chromophore. On the basis of the proposed models of intercalation, these results could be rationalized in terms of steric influence of the bulky methoxy group. The results of this study are in agreement with the correlation already observed between DNA binding and relative antitumor activity of anthracyclines. 相似文献
77.
Successful Liver and Kidney Transplantation From Cadaveric Donors With Left-Sided Bacterial Endocarditis 总被引:1,自引:0,他引:1
Francisco Caballero Antonio Lopez-Navidad Milagrosa Perea Catiana Cabrer Lluis Guirado Ricard Solà 《American journal of transplantation》2005,5(4):781-787
Bacterial infections are frequent in cadaveric organ donors and can be transmitted to the transplantation recipient, which could have devastating consequences for the recipients if adequate preventive measures are not adopted.
From the 355 consecutive brain dead cadaveric organ donors procured at our center in the last four years, 2000–2003, four of them (1.1%) had bacterial endocarditis as cause of death. The bacteria responsible for the endocarditis were Staphylococcus epidermidis, coagulase-negative Staphylococcus , Staphylococcus hominis and Streptococcus viridans , respectively. We performed five kidney and two liver transplantations on seven recipients. All donors and recipients received antibiotic treatment against the germ causing the respective endocarditis.
Infection by the bacteria responsible for the endocarditis in the respective donors was not transmitted to any of the recipients. Six of the seven recipients were alive with normal-functioning grafts after between 13 and 24 months' follow-up. Transplantectomy was performed on one kidney recipient due to thrombosis of the renal vein of the graft not related to the endocarditis.
Liver and kidney transplantation from donors dying from bacterial endocarditis can be performed without causing the transmission of infection to the recipient or the dysfunction of the graft. 相似文献
From the 355 consecutive brain dead cadaveric organ donors procured at our center in the last four years, 2000–2003, four of them (1.1%) had bacterial endocarditis as cause of death. The bacteria responsible for the endocarditis were Staphylococcus epidermidis, coagulase-negative Staphylococcus , Staphylococcus hominis and Streptococcus viridans , respectively. We performed five kidney and two liver transplantations on seven recipients. All donors and recipients received antibiotic treatment against the germ causing the respective endocarditis.
Infection by the bacteria responsible for the endocarditis in the respective donors was not transmitted to any of the recipients. Six of the seven recipients were alive with normal-functioning grafts after between 13 and 24 months' follow-up. Transplantectomy was performed on one kidney recipient due to thrombosis of the renal vein of the graft not related to the endocarditis.
Liver and kidney transplantation from donors dying from bacterial endocarditis can be performed without causing the transmission of infection to the recipient or the dysfunction of the graft. 相似文献
78.
79.
Eugenio Neri Lucio Barabesi Dimitrios Buklas Luca A. Vricella Antonio Benvenuti Enrico Tucci Carlo Sassi Massimo Massetti 《European journal of cardio-thoracic surgery》2005,28(6):857-863
Objective: Increased dimension of the aortic root and proximal aorta is considered a significant risk factor for catastrophic events that involve the ascending aorta. The objective of this study was to determine the possible correlation between pre-dissection aortic diameter and the occurrence of Stanford type A aortic dissection. Methods: Samples of dissected ascending aortas were obtained from 220 patients at the time of their operation. Two groups were identified: patients with connective tissue disorders (Group 1, n = 94) and those without (Group 2, n = 126). Measurements of the true (intimal) lumen were conducted and extrapolated as reliable approximation of pre-dissection aortic diameter. The possible association of intimal diameter with anthropometric and demographic data was analyzed. Results: Median aortic diameter was, respectively, 41.8 and 41.3 mm for patients with and without connective tissue disorders (41.4 mm for the entire cohort). Data analysis indicated that 57% of patients had aortic diameter above 40 mm, while patients with frank aneurysm accounted only for 10%; this proportion was higher in Group 1 compared to Group 2 (17.2% vs 4.7%). Poor or no correlation was demonstrated between aortic size and any of the anthropometric or demographic variables essayed. Significant subgroup differences were found among patients with a history of cigarette smoking, hypertension, diabetes, chronic renal insufficiency, and bicuspid aortic valve. Conclusion: Although aortic diameter remains a strong indication for preventive surgery in patients with inherited connective tissue disorders, acute aortic dissection occurs rarely in the setting of true ascending aortic aneurysms, and despite normal or near-normal aortic size in more than one-third of subjects. Dissection superimposing on small aortic diameters can be regarded as an expression of substantial functional tissue susceptibility to aortic catastrophic events. 相似文献
80.