全文获取类型
收费全文 | 6120篇 |
免费 | 403篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 63篇 |
儿科学 | 93篇 |
妇产科学 | 150篇 |
基础医学 | 794篇 |
口腔科学 | 61篇 |
临床医学 | 679篇 |
内科学 | 1453篇 |
皮肤病学 | 76篇 |
神经病学 | 534篇 |
特种医学 | 230篇 |
外科学 | 998篇 |
综合类 | 39篇 |
预防医学 | 332篇 |
眼科学 | 113篇 |
药学 | 387篇 |
中国医学 | 5篇 |
肿瘤学 | 553篇 |
出版年
2024年 | 10篇 |
2023年 | 61篇 |
2022年 | 103篇 |
2021年 | 235篇 |
2020年 | 162篇 |
2019年 | 219篇 |
2018年 | 262篇 |
2017年 | 170篇 |
2016年 | 181篇 |
2015年 | 160篇 |
2014年 | 251篇 |
2013年 | 327篇 |
2012年 | 490篇 |
2011年 | 405篇 |
2010年 | 248篇 |
2009年 | 236篇 |
2008年 | 365篇 |
2007年 | 368篇 |
2006年 | 364篇 |
2005年 | 339篇 |
2004年 | 283篇 |
2003年 | 261篇 |
2002年 | 259篇 |
2001年 | 80篇 |
2000年 | 64篇 |
1999年 | 57篇 |
1998年 | 59篇 |
1997年 | 49篇 |
1996年 | 48篇 |
1995年 | 41篇 |
1994年 | 27篇 |
1993年 | 15篇 |
1992年 | 29篇 |
1991年 | 30篇 |
1990年 | 28篇 |
1989年 | 29篇 |
1988年 | 24篇 |
1987年 | 21篇 |
1986年 | 21篇 |
1985年 | 17篇 |
1984年 | 11篇 |
1983年 | 9篇 |
1982年 | 7篇 |
1981年 | 10篇 |
1976年 | 10篇 |
1974年 | 7篇 |
1973年 | 7篇 |
1972年 | 12篇 |
1970年 | 11篇 |
1969年 | 9篇 |
排序方式: 共有6560条查询结果,搜索用时 15 毫秒
991.
992.
Pre‐ and Postoperative Chemotherapy in Localized Extremity Soft Tissue Sarcoma: A European Organization for Research and Treatment of Cancer Expert Survey 下载免费PDF全文
993.
Xavier Mignard Anne-Marie Ruppert Martine Antoine Julie Vasseur Nicolas Girard Julien Mazières Denis Moro-Sibilot Vincent Fallet Nathalie Rabbe Françoise Thivolet-Bejui Isabelle Rouquette Sylvie Lantuejoul Alexis Cortot Raphaël Saffroy Jacques Cadranel Antoinette Lemoine Marie Wislez 《Journal of thoracic oncology》2018,13(12):1962-1967
Introduction
MNNG HOS transforming gene (MET) abnormalities such as amplification and exon 14 mutations may be responsive to targeted therapies. They are prevalent in lung sarcomatoid carcinomas (LSCs) and must be diagnosed as efficiently as possible. Hypothetically, c-MET overexpression by immunohistochemistry (IHC) may prove effective as a screening test for MET abnormalities.Methods
Tissue samples were obtained from consecutive patients with a resected LSC in four oncologic centers. IHC was performed using the SP44 antibody (Ventana, Tucson, Arizona) and evaluated using the MetMab score and H-score. Fluorescence in situ hybridization was applied with the dual color probe set from Zytovision (Clinisciences, Nanterre, France). True MET amplification was diagnosed when MET gene copy number was 5 or greater and the ratio between MET gene copy number and chromosome 7 number was greater than 2. All MET exon 14 alterations including those affecting splice sites occurring within splice donor and acceptor sites were detected in the routine molecular testing on genetic platforms.Results
A total of 81 LSCs were included. Fourteen (17%) exhibited positive IHC using the MetMab score and 15 (18.5%) using the H-score. MET amplification was detected in six tumors (8.5%) and MET exon 14 mutation in five (6%). A weak positive correlation between IHC and fluorescence in situ hybridization was found (r = 0.27, p = 0.0001). IHC sensitivity for MET amplification was 50%, with a specificity of 83%, positive predictive value of 21.4%, and negative predictive value of 94.7%. IHC sensitivity for MET exon 14 mutations was 20%, with a specificity of 83%, positive predictive value of 7%, and negative predictive value of 94%.Conclusion
IHC is not a relevant screening tool for MET abnormalities in LSC. 相似文献994.
Antoine Angelergues Eleni Efstathiou Revekka Gyftaki Piotr Jan Wysocki Nuria Lainez Iria Gonzalez Daniel E. Castellano Mustafa Ozguroglu Iciar Garcia Carbonero Aude Flechon Pablo Borrega Aline Guillot Begona Campos Balea Sylvestre Le Moulec Emilio Esteban Javier Munarriz Gustavo Rubio Alison J. Birtle Stéphane Oudard 《Clinical genitourinary cancer》2018,16(4):e777-e784
Background
Several agents have demonstrated an overall survival (OS) benefit in patients with metastatic castration-resistant prostate cancer (mCRPC); however, the optimal sequencing of these therapies is unknown as a result of a lack of prospective randomized controlled trials. This retrospective study aimed to identify clinical factors influencing outcomes and to determine optimal treatment sequencing in patients with mCRPC treated with cabazitaxel (CABA) and/or androgen receptor–targeted agents (ART) after androgen-deprivation therapy (ADT) and docetaxel (DOC).Patients and Methods
Records of 574 consecutive patients treated (2012?2016) at 44 centers in 6 countries were retrospectively examined.Results
A total of 267 patients received ADT → DOC → CABA (group 1), 183 patients ADT → DOC → ART → CABA (group 2), and 124 patients ADT → DOC → CABA → ART (group 3), with respective median OS from diagnosis of mCRPC of 38.3, 44.45, and 53.9 months (P = .012 for group 3 vs. group 1). Multivariate analysis showed response to first ADT ≤ 12 months, Gleason score of 8 to 10, clinical progression, and high prostate-specific antigen levels at mCRPC diagnosis were associated with worse OS. Prior receipt of ART did not influence activity of CABA.Conclusion
OS appeared to increase with the number of life-extending therapies, with a sequence including DOC, CABA, and an ART providing the greatest OS benefit. 相似文献995.
Johannes T.M. van Gemert MD DMD Jan H. Abbink PhD Robert J.J. van Es MD DMD PhD Antoine J.W.P. Rosenberg MD DMD PhD Ron Koole MD DMD PhD Ellen M. Van Cann MD DMD PhD 《Journal of surgical oncology》2018,117(4):773-780
Background and Objectives
Evaluation of mandibular reconstructions with free fibula flaps. Identification of factors associated with major recipient site complications, that is, necessitating surgical intervention under general anaesthesia.Methods
Seventy‐nine reconstructions were included. The following factors were analyzed: fixation type, number of osteotomies, site of defect (bilateral/unilateral), surgeon, sex, ASA classification, continuous smoking, pathological N‐stage, age, defect size, flap ischemic time, and postoperative radiotherapy. Proportional hazards regression was used to test the effect on the time between reconstruction and intervention.Results
Sixty‐nine (87%) of the 79 fibula flaps were successful at the last follow‐up. Forty‐eight major recipient site complications occurred in 41 reconstructions. Nineteen complications required surgical intervention within six weeks and were mostly vascular problems, necessitating immediate intervention. These early complications were associated with defects crossing the midline, with an estimated relative risk of 5.3 (CI 1.1‐20, P = 0.01). Twenty‐nine complications required surgical intervention more than 6 weeks after the reconstruction. These late complications generally occurred after months or years, and were associated with smoking, with an estimated relative risk of 2.8 (CI 1.0‐8.3, P = 0.05).Conclusions
Fibula flaps crossing the midline have a higher risk of early major recipient site complications than unilateral reconstructions. Smoking increases the risk of late complications. 相似文献996.
Yassine?Al TabaaEmail author Emmanuelle?Tchernonog Pierre?Faurie Anne?Ségolène?Cottereau Hélène?Monjanel Antoine?Bonnet Steven?Le Gouill Emmanuel?Gyan Hervé?Ghesquieres Denis?Mariano-Goulart Guillaume?Cartron 《European journal of nuclear medicine and molecular imaging》2018,45(10):1705-1709
Purpose
Plasmablastic lymphoma (PBL) is a rare variant of diffuse large B cell lymphomas (DLBCL) clinically characterized by a poorer prognostic. Few clinical and imaging data are available and derived from pooled case reports and small series. The aim of the study was to evaluate the FDG avidity at baseline and the utility of 18-Fluorodeoxyglucose (FDG) positron-emission-tomography/computed-tomography (PET/CT) for staging and response assessment.Methods
Patients with newly diagnosed PBL seen at Lymphoma Study Association centers during the period 2005–2015 were included if they underwent a PET/CT at staging and at the end of treatment (eotPET) and had received an anthracycline-based first line therapy. EotPET scans were analyzed using the 5-point-scale visual analysis in accordance with Lugano criteria. Patients were classified in complete metabolic response (CMR) or no-CMR including partial metabolic response (PMR), stable disease (SD) and progression disease (PD). EotPET results were assessed for the ability to predict event free survival (EFS) and overall survival (OS).Results
Thirty-five PBL patients fulfilled the inclusion criteria. The median follow-up was 34 months (2.8–120 months). FDG avidity was found in all patients at diagnosis. Most patients (80%) achieved CMR, and 20% were no-CMR including 9% PMR, 6% SD, and 6% PD. A CMR after first line chemotherapy predicted higher EFS (p?<?0.0001) and OS (p?=?0.0006).Conclusions
This study confirmed the FDG avidity of PBL subtype and the usefulness of PET/CT scanning in restaging an aggressive lymphoma at the completion of chemotherapy. EotPET can predict outcomes following treatment in patients with PBL.997.
Dario?Di PerriEmail authorView authors OrcID profile Andréa?Colot Antoine?Delor Randa?Ghoul Guillaume?Janssens Valérie?Lacroix Pascal?Matte Annie?Robert Kevin?Souris Xavier?Geets 《Strahlentherapie und Onkologie》2018,194(6):591-599
Purpose
By increasing lung volume and decreasing respiration-induced tumour motion amplitude, administration of continuous positive airway pressure (CPAP) during stereotactic ablative radiotherapy (SABR) could allow for better sparing of the lungs and heart. In this study, we evaluated the effect of CPAP on lung volume, tumour motion amplitude and baseline shift, as well as the dosimetric impact of the strategy.Methods
Twenty patients with lung tumours referred for SABR underwent 4D-computed tomography (CT) scans with and without CPAP (CPAP/noCPAP) at two timepoints (T0/T1). First, CPAP and noCPAP scans were compared for lung volume, tumour motion amplitude, and baseline shift. Next, CPAP and noCPAP treatment plans were computed and compared for lung dose parameters (mean lung dose (MLD), lung volume receiving 20 Gy (V20Gy), 13 Gy (V13Gy), and 5 Gy (V5Gy)) and mean heart dose (MHD).Results
On average, CPAP increased lung volume by 8.0% (p?<?0.001) and 6.3% (p?<?0.001) at T0 and T1, respectively, but did not change tumour motion amplitude or baseline shift. As a result, CPAP administration led to an absolute decrease in MLD, lung V20Gy, V13Gy and V5Gy of 0.1?Gy (p?=?0.1), 0.4% (p?=?0.03), 0.5% (p?=?0.04) and 0.5% (p?=?0.2), respectively, while having no significant influence on MHD.Conclusions
In patients referred for SABR for lung tumours, CPAP increased lung volume without modifying tumour motion or baseline shift. As a result, CPAP allowed for a slight decrease in radiation dose to the lungs, which is unlikely to be clinically significant.998.
Jessica Moretta Pascaline Berthet Valérie Bonadona Olivier Caron Odile Cohen-Haguenauer Chrystelle Colas Carole Corsini Véronica Cusin Antoine De Pauw Capucine Delnatte Sophie Dussart Christophe Jamain Michel Longy Elisabeth Luporsi Christine Maugard Tan Dat Nguyen Pascal Pujol Dominique Vaur Catherine Noguès 《Bulletin du cancer》2018,105(10):907-917
999.
Sanjiv K. Agarwal Gordon A. McLorie Deepa Grewal Byron D. Joyner Darius J. Bagli Antoine E. Khoury 《The Journal of urology》1997,158(2):580-582
Purpose
Resolution of reflux in meningomyelocele patients is a reflection of improved bladder storage. We correlated resolution of reflux with changes observed in sequential urodynamic studies.Materials and Methods
The study included 27 children with meningomyelocele born between 1975 and 1985 who presented with or developed vesicoureteral reflux. Resolution of reflux was observed during the 10-year followup period as they were treated with a regimen of clean intermittent catheterization and pharmaco-therapy. Urodynamic studies were performed when vesicoureteral reflux was present and subsequent to its resolution. The urodynamic parameters compared in the 2 studies included bladder capacity, pressure specific bladder volume, bladder compliance and leak point pressure.Results
Significant increases in bladder capacity, pressure specific bladder volume and bladder compliance were noted. Leak point pressure appeared to be decreased subsequent to resolution of reflux.Conclusions
Resolution of reflux in meningomyelocele patients correlates with changes in parameters of bladder storage observed on sequential urodynamic studies. 相似文献1000.