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61.
Sarah Denayer François E. Dufrasne Bert Monsieurs Reinout van Eycken Sarah Houben Lucie Seyler Thomas Demuyser Els van Nedervelde Marc Bourgeois Bénédicte Delaere Koen Magerman Door Jouck Bénédicte Lissoir Catherine Sion Marijke Reynders Evelyn Petit Nicolas Dauby Marc Hainaut Lies Laenen Piet Maes Guy Baele Simon Dellicour Lize Cuypers Emmanuel André Simon Couvreur Ruben Brondeel Cyril Barbezange Nathalie Bossuyt Steven van Gucht 《Influenza and other respiratory viruses》2023,17(10):e13202
Background
To support the COVID-19 pandemic response, many countries, including Belgium, implemented baseline genomic surveillance (BGS) programs aiming to early detect and characterize new SARS-CoV-2 variants. In parallel, Belgium maintained a sentinel network of six hospitals that samples patients with severe acute respiratory infections (SARI) and integrated SARS-CoV-2 detection within a broader range of respiratory pathogens. We evaluate the ability of the SARI surveillance to monitor general trends and early signals of viral genetic evolution of SARS-CoV-2 and compare it with the BGS as a reference model.Methods
Nine-hundred twenty-five SARS-CoV-2 positive samples from patients fulfilling the Belgian SARI definition between January 2020 and December 2022 were sequenced using the ARTIC Network amplicon tiling approach on a MinION platform. Weekly variant of concern (VOC) proportions and types were compared to those that were circulating between 2021 and 2022, using 96,251 sequences of the BGS.Results
SARI surveillance allowed timely detection of the Omicron (BA.1, BA.2, BA.4, and BA.5) and Delta (B.1.617.2) VOCs, with no to 2 weeks delay according to the start of their epidemic growth in the Belgian population. First detection of VOCs B.1.351 and P.1 took longer, but these remained minor in Belgium. Omicron BA.3 was never detected in SARI surveillance. Timeliness could not be evaluated for B.1.1.7, being already major at the start of the study period.Conclusions
Genomic surveillance of SARS-CoV-2 using SARI sentinel surveillance has proven to accurately reflect VOCs detected in the population and provides a cost-effective solution for long-term genomic monitoring of circulating respiratory viruses. 相似文献62.
Verheyden Christophe Neyrinck Arne Laenen Annouschka Rex Steffen Van Gerven Elke 《Journal of clinical monitoring and computing》2022,36(5):1279-1287
Journal of Clinical Monitoring and Computing - We evaluated the disposable non-invasive SpotOn? thermometer relying on the zero-heat-flux technology. We tested the hypothesis that this... 相似文献
63.
Influence of intravenous clonidine pretreatment on anesthetic requirements during bispectral EEG-guided sevoflurane anesthesia 总被引:1,自引:0,他引:1
De Deyne C Struys M Heylen R De Jongh R Van der Laenen M Buyse L Deghislage J Rolly G 《Journal of clinical anesthesia》2000,12(1):52-57
STUDY OBJECTIVE: To assess the anesthetic effects of clonidine during sevoflurane anesthesia guided by the bispectral index (BIS), which is a processed EEG variable correlated with anesthetic-hypnotic depth. DESIGN: Placebo-controlled, double-blind clinical trial. SETTINGS: Elective laparoscopic surgery. PATIENTS: 60 ASA physical status I patients scheduled for laparoscopic surgery. INTERVENTIONS: Patients received either clonidine (3 micrograms/kg, 15 min before induction) or placebo premedication for a sevoflurane-induced and sevoflurane-maintained anesthesia. Sevoflurane was titrated against a BIS held between 40 and 50. Analgesia was provided by local infiltration with bupivacaine. Need for postoperative analgesia was recorded. RESULTS AND CONCLUSION: Mean sevoflurane requirements were not lower with clonidine pretreatment. There was statistically better perioperative hemodynamic stability (i.e., fewer episodes of hypertension and tachycardia) without clinical relevance. A decreased need for postoperative analgesia was observed. 相似文献