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51.
对115例脑血管疾病病人血清免疫球蛋白(Ig)、补体C_3和循环免疫复合物(CIC)进行了测定,并对其中的67例急性期脑血管病病人脑脊液Ig,补体C_3,白蛋白、IgG指数进行检测;对缺血性脑血管病进行了脑动脉硬化期、TIA期、急性发作期、恢复期的动态观察.结果表明,缺血性脑血管病病人体液免疫指标随着病情的加重有升高的趋势.脑出血和蛛网膜下腔出血都有体液免疫反应增强和血脑屏障破坏(BBB),后者还有CIC的形成增多.缺血性脑血管病的动态观察发现其临床前期、急性期及恢复期体液免疫变化持续存在.提示缺血性脑血管病的发病原理可能与免疫反应有密切关系. 相似文献
52.
目的 研究乳腺浸润性微乳头状癌(invasive micropapillary carcinoma of the breast,IMPC)的临床病理特征以及生存预后分析。方法 选择2006年6月至2013年6月在本院收治的IMPC 29例,中位随访42个月,分析其临床病理特点、局部复发率、远处转移率及总生存率(overall survival,OS)等生存预后指标;与320例浸润性导管癌(invasive ductal carcinoma,IDC)病例进行对照,分析比较两组间的临床病理特点及生存预后指标。为进一步探讨IMPC病理类型对于生存预后的影响,将58例IDC与29例IMPC进行2∶1配对对照研究,分析比较两组间的生存预后指标。结果 29例IMPC中23例(79.3%)发生淋巴结转移,其中4枚及以上淋巴结转移的有15例(51.7%),18例(62.1%)伴有脉管侵犯。分子分型以Luminal B型为主(21例)。3年无局部复发生存率(local recurrence free survival,LRFS)、无转移生存率(metastasis free survival,MFS)、OS分别为:74%、86%、90%。Cox回归分析得出淋巴结转移个数是IMPC局部复发的影响因素(P=0.048)。与IDC组比较,IMPC组肿瘤体积大(3.70 cm vs.2.81 cm,P=0.007),淋巴结转移率高(79.3% vs.45.0%,P<0.001),淋巴结转移个数多(5.90 vs.2.16,P=0.003),淋巴结分级高分级比例较高(N2:24.1% vs.7.5%,N3:27.6% vs.6.9%,P<0.001),脉管侵犯率高(62.1% vs.20.0%,P<0.001),手术方式中标准根治术比例高(24.2% vs.3.1%,P<0.001),化疗方式中新辅助化疗比例高(31.0% vs.9.1%,P<0.001),其余方面差异无统计学意义。Log Rank检验生存分析得出IMPC组的LRFS显著低于IDC组(P=0.001),但两组间的MFS及OS差异无统计学意义(P=0.074及0.106)。将58例IDC与29例IMPC进行配对对照研究,Log Rank检验生存分析得出两组间的LFRS、MFS与OS差异均无统计学意义(P=0.586、0.965、0.920)。 结论 乳腺IMPC是一类预后较差的特殊类型乳腺癌,其较高的淋巴脉管侵犯性而非这一病理类型,与肿瘤的生存预后相关。 相似文献
53.
Yan Liu Ang Li Xiuli Feng Xiaoyan Jiang Xiao Sun Weizhen Huang Xiaosong Zhu Zhongxi Zhao 《RSC advances》2018,8(17):9353
l-Menthol is the main ingredient of peppermint which affects various pharmacological effects such as anti-inflammation and anti-oxidative activity. In this study, we aimed to evaluate the potential effects of l-menthol on cigarette smoke extract (CSE) induced lung injury in rats. Morphology assessment results revealed that administration with l-menthol (5, 10 or 20 mg kg−1 d−1) significantly alleviated CSE-induced lung injury. Besides, l-menthol significantly reduced the inflammatory response by suppressing the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) via downregulating nuclear factor kappa B (NF-κB) and p38 MAPK pathways. Meanwhile, l-menthol decreased the levels of oxidative stress markers including malondialdehyde (MDA) and myeloperoxidase (MPO) whereas it increased the amount of glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) through activation of the Nrf2 pathway. Furthermore, the expression of MMP-9 and TIMP-1 in lungs was reduced after treatment with l-menthol, and this indicated that l-menthol might have a potential effect on airway remodeling. Moreover, immunohistochemistry analyses indicated that l-menthol could suppress the infiltration of CD4+ and CD8+ T cells in lung tissues and this was probably due to the immune regulation activity of l-menthol. Taken together, our findings support that l-menthol might be a potential candidate for the treatment of CSE-induced lung injury in rats. l-Menthol is the main ingredient of peppermint which affects various pharmacological effects such as anti-inflammation and anti-oxidative activity. 相似文献
54.
Wei Wang Ang Zheng Yifan Jiang Dongsheng Lan Fenghua Lu Lelin Zheng Lin Zhuang Ruijiang Hong 《RSC advances》2018,9(1):498
Monodisperse colloidal particles have promising applications in electrophoretic displays with vivid colors, reversibility and low switching times. In this study, a facile, effective and large-scale strategy for preparing size-controlled Fe3O4@SiO2 particles is reported. Multiple Fe3O4 particles were synthesized by a modified solvothermal method using sodium citrate as a surface modifier with a binary solvent, and were then coated with a SiO2 layer to obtain a highly negatively charged surface via a modified Stöber method. Owing to the easily controlled sizes and sufficient surface charges, Fe3O4@SiO2 particles can be assembled into colloidal amorphous arrays with the balance of electrostatic repulsion and electrophoretic forces. The reflections cover wavelengths ranging from 802 to 453 nm, and were optimized by investigating the dependence of the particles on variables such as particle size, particle volume fraction, and electric field intensity. The large-scale preparation of electrically responsive Fe3O4@SiO2 particles facilitates an electrophoretic display with broad-range colors, showing the practical potential in industrial application.Fe3O4@SiO2 particles were prepared on the gram-scale by selecting Na3Cit as the modifier with binary solvent and were assembled into colloidal amorphous arrays with unique and attractive optical properties for EPD. 相似文献
55.
Mariana Angélica Peixoto De Souza Marisa Cotta Mancini Wendy Jane Coster Renata Noce Kirkwood Elyonara Mello De Figueiredo Rosana Ferreira Sampaio 《Revista brasileira de fisioterapia (S?o Carlos (S?o Paulo, Brazil))》2018,22(2):135-143
Background
The Activity Measure for Post-Acute Care was developed to evaluate the limitations of activities of adult individuals with different health conditions.Objectives
To translate and cultural adapt the Activity Measure for Post-Acute Care short forms for outpatients into Portuguese–Brazilian, to verify the comprehension of the items and categories of the responses by users of the rehabilitation services and to analyze the reliability indices of the instrument.Methods
Translation and back-translation were conducted by two independent teams. Cognitive interviews (n = 2) evaluated the comprehension of the translated version among patients. Item reliability and consistency was also investigated.Results
There was conceptual equivalence between the translated and original versions. For some items, the information was modified in order to attend to the measurement units used in Brazil. Comparative analyses of the translated versions chose the most appropriate term to capture the English content. The few discrepancies identified in the back-translation were solved by consensus. The cognitive interviews detected few comprehension problems, which were solved by means of repetition of the item statement and use of examples to clarify the specificity of the information. The final translated short forms of the instrument showed excellent test-retest reliability and inter-examiner reliability indices, as well as high internal consistency.Conclusion
The Portuguese version of the Activity Measure for Post-Acute Care short forms will provide Brazilian clinicians and researchers with an up-to-date instrument for the evaluation of functioning of adults with various clinical conditions who attend outpatient rehabilitation settings. 相似文献56.
Oytip Nathalang Roanne Marion Ang Benjamaporn Kurin Siralak Limprasert Supattra Mitundee Nipapan Leetrakool Kamphon Intharanut 《Transfusion and apheresis science》2018,57(4):582-586
Background
S and s antigens of the MNS system are of clinical importance because alloanti-S and -s have usually caused delayed hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. Various red cell genotyping has been established to predict the phenotypes to solve serological test limitations.Objectives and methods
This study aimed to determine S and s genotype frequencies and to estimate the alloimmunization risks among central, northern and southern Thai populations. Altogether, 1237 blood samples from Thai blood donors were included. Only 150 samples were tested with anti-S and anti-s by indirect antiglobulin test. All samples were genotyped for GYPB*S and GYPB*s alleles using inhouse PCR with sequence-specific primer. Additionally, the allele frequencies were used to estimate alloimmunization risks and compare with other populations.Results
The phenotyping and genotyping results in 150 samples were in 100% concordance. The allele frequencies of GYPB*S in central, northern and southern Thais were 0.061, 0.040 and 0.097, and GYPB*s were 0.939, 0.960 and 0.903, respectively. The frequencies among central Thais were similar to those among northern Thai and Korean populations (P?>?0.05) but significantly differed from those of Asian, Caucasian African American and Hispanic populations (P?<?0.05). In addition, the risk of S alloimmunization among southern Thais (0.1566) was higher than those among central (0.1038) and northern Thais (0.0736).Conclusion
This was the first study to report S and s predicted phenotypes and estimate alloimmunization risks among Thais, which is beneficial to prevent transfusion-induced alloimmunization among donors and patients. 相似文献57.
Comparison of sonographic inferior vena cava and aorta indexes during fluid administered in children
Yun Ang Choi Hyuksool Kwon Jin Hee Lee Jae Yun Jung Yoo Jin Choi 《The American journal of emergency medicine》2018,36(9):1529-1533
Objectives
This prospective, observational study evaluated changes in ultrasound measurements of the inferior vena caval index (IVCI), the aorta diameter/IVC diameter index (Ao/IVCD), and the aorta area/IVC area index (Ao/IVCA) during fluid administration in children requiring intravenous fluid administration.Methods
Children who presented to the pediatric emergency department with symptoms of dehydration were enrolled between May 2015 and February 2016. The maximum diameter of the aorta, from inner wall to inner wall, and the long and short axis diameters of IVC were measured using a convex array transducer in the transverse view. Subsequently, we measured the diameter of the IVC at the subxiphoid area during inspiration and expiration in longitudinal view. We calculated IVCI, Ao/IVCD, and Ao/IVCA during administration of 10 ml/kg and 20 ml/kg normal saline boluses.Results
IVCI and Ao/IVCA significantly changed immediately after administration of initial 10 ml/kg of NS. Ao/IVCA showed significant change during the additional administration of 10 ml/kg (total 20 ml/kg) normal saline boluses (1.43, IQR 1.12–1.86 vs. 1.08, IQR 0.87–1.45, p value < 0.001). No significant changes were observed for IVCI and Ao/IVCD. Ao/IVCA was significantly correlated with the volume of fluid administered. The coefficient between initial and administration of the 10 ml/kg normal saline bolus was ? 0.396 (p value = 0.010), and that between the 10 ml/kg and 20 ml/kg normal saline boluses was ? 0.316 (p value = 0.038).Conclusions
Ao/IVCA showed better correlations with the volume of fluid administered than IVCI and Ao/IVCA. Ao/IVCA might be a promising index for assessing the effects of fluid administration. 相似文献58.
Fernández-Torres Javier Martínez-Nava Gabriela Angélica Zamudio-Cuevas Yessica Barbier Olivier Christophe Narváez-Morales Juana Martínez-Flores Karina 《Clinical rheumatology》2021,40(1):279-285
Clinical Rheumatology - Articular cartilage and periarticular muscle tissues are strongly affected during knee osteoarthritis (OA). Creatine kinase (CK) is an enzyme expressed in several tissues,... 相似文献
59.
Mejia-Vilet Juan M. Gómez-Ruiz Ismael A. Cruz Cristino Méndez-Pérez R. Angélica Comunidad-Bonilla Roque A. Uribe-Uribe Norma O. Nuñez-Alvarez Carlos A. Morales-Buenrostro Luis E. 《Clinical rheumatology》2021,40(6):2233-2242
Clinical Rheumatology - Thrombotic microangiopathy (TMA) in systemic lupus erythematosus is a rare manifestation associated with activation of the complement system. This study aimed to compare... 相似文献
60.
Fan Bingwen Eugene Ng Jensen Chan Stephrene Seok Wei Christopher Dheepa Tso Allison Ching Yee Ling Li Min Young Barnaby Edward Wong Lester Jun Long Sum Christina Lai Lin Tan Hwee Tat Ang Mui Kia Lim Gek Hsiang Ong Kiat Hoe Kuperan Ponnudurai Chia Yew Woon 《Journal of thrombosis and thrombolysis》2021,51(3):663-674
Journal of Thrombosis and Thrombolysis - Patients with COVID-19 are known to be at risk of developing both venous, arterial and microvascular thrombosis, due to an excessive immuno-thrombogenic... 相似文献