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91.
Chantal Fussler Anetta Weber J. F. O'Hanlon N. Blau R. Gierer et E. Grandjean 《Sozial- und Pr?ventivmedizin》1980,25(4):207-208
Résumé Dans notre étude de laboratoire 19 sujets ont effectué 4 tâches répétitives de 70 minutes ayant toutes une tâche motrice de base et dont 2 avaient en plus un travail avec nécessité de discrimination. Dans les 2 tâches avec discrimination l'Electromyographie des muscles de la nuque est nettement plus élevée que dans les 2 autres tâches. Les tâches avec discrimination se distinguent également par une tension subjective augmentée, une variabilité cardiaque diminuée et une excrétion urinaire d'adrénaline légèrement augmentée. Le facteur essentiel provoquant une augmentation du tonus musculaire serait l'immobilisation de la nuque.
Summary In our laboratory study 19 students effected 4 repetitive tasks of 70 min each. All four conditions had a motor task at the base and in addition two had to deal with discrimination. In the 2 tasks with discrimintion, the electromyography of the neck muscles was distinctly higher than in the 2 other conditions. The tasks with discrimination were accompanied by a higher subjective tension, a lower heart rate variability and a slightly increased urinary excretion. The main cause for an augmentation in the muscle tonus might be the immobilisation of the neck.
Zusammenfassung In unserer Laboruntersuchung haben 19 Versuchspersonen 4 repetitive Arbeiten von je 70 min ausgeführt. Allen 4 Bedingungen lag eine motorische Aufgabe zugrunde und 2 beinhalteten zusätzlich eine Diskriminationsaufgabe. In den beiden Arbeiten mit Diskrimination ist die Elektromyographie der Nackenmuskulatur deutlich höher als in den beiden andern Arbeiten. Die Arbeiten mit Diskrimination unterscheiden sich ebenfalls durch eine erhöhte subjektive Spannung, eine herabgesetzte Herzfrequenzvariabilität und eine leicht erhöhte Adrenalin Ausscheidung im Urin. Der Hauptfaktor, der eine Zunahme des Muskeltonus verursacht, ist vermutlich die geringe Mobilität des Nackens.相似文献
92.
93.
Validation for histology‐driven diagnosis in non‐small cell lung cancer using hsa‐miR‐205 and hsa‐miR‐21 expression by two different normalization strategies
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Radoslaw Charkiewicz Lothar Pilz Anetta Sulewska Miroslaw Kozlowski Wieslawa Niklinska Marcin Moniuszko Joanna Reszec Christian Manegold Jacek Niklinski 《International journal of cancer. Journal international du cancer》2016,138(3):689-697
Targeted therapy of non‐small cell lung cancer (NSCLC) demands a more accurate tumor classification that is crucial for patient selection in personalized treatment. MicroRNAs constitute a promising class of biomarkers and a helpful tool for the distinction between lung adenocarcinoma (AC) and squamous cell lung carcinoma (SCC). The aim of this study was to evaluate the impact of two different normalization strategies, using U6 snRNA and hsa‐miR‐103 as reference genes, on hsa‐miR‐205 and hsa‐miR‐21 expression levels, in terms of the classification of subtypes of NSCLC. By means of a quantitative real‐time polymerase chain reaction (qRT‐PCR) microRNA expression levels were evaluated in a classification set of 98 surgically resected NSCLC fresh‐frozen samples, and validated findings in an independent set of 42 NSCLC samples. The microRNA expression levels were exploited to develop a diagnostic test using two data normalization strategies. The performance of microRNA profiling in different normalization methods was compared. We revealed the microRNA‐based qRT‐PCR tests to be appropriate measures for distinguishing between AC and SCC (the concordance of histologic diagnoses and molecular methods greater than 88%). Performance evaluation of microRNA tests, based on the two normalization strategies, showed that the procedure using hsa‐miR‐103 as reference target has a slight advantage (sensitivity 83.33 and 100% in classification and validation set, respectively) compared to U6 snRNA. Molecular tests based on microRNA expression allow a reliable classification of subtypes for NSCLC and can constitute a useful diagnostic strategy in patient selection for targeted therapy. 相似文献
94.
Hypoglycosylation is a common finding in antithrombin deficiency in the absence of a SERPINC1 gene defect
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95.
Piotr Mazur Grzegorz Sokołowski Alicja Hubalewska-Dydejczyk Ewa Płaczkiewicz-Jankowska Anetta Undas 《Thrombosis research》2014
Introduction
Available data on fibrin clot properties and fibrinolysis in hyperthyroidism and hypothyroidism are inconsistent. Our objective was to assess the impact of effective treatment of hyper- and hypothyroidism on fibrin clot characteristics.Material and Methods
In a case-control study, ex vivo plasma fibrin clot permeability (Ks) and efficiency of fibrinolysis were assessed in 35 consecutive hyperthyroid and 35 hypothyroid subjects versus 30 controls. All measurements were performed before and after 3 months of thyroid function normalizing therapy.Results
At baseline, hyperthyroid, but not hypothyroid, patients had lower Ks than controls (p < 0.0001). Hyperthyroid and hypothyroid groups compared with controls had prolonged clot lysis time (CLT), and lower rate of D-dimer release from clots (D-Drate) (all p < 0.05). The regression analysis adjusted for fibrinogen showed that in hyperthyroid patients, pre-treatment thyroid stimulating hormone (TSH) independently predicted Ks, while thrombin activatable fibrinolysis inhibitor (TAFI) antigen predicted CLT. In hypothyroid individuals a similar regression model showed that TSH independently predicts CLT. After 3 months of thyroid function normalizing therapy, 32 (91.4%) hyperthyroid and 30 (85.7%) hypothyroid subjects achieved euthyroidism and had improved fibrin clot properties (all p < 0.05), with normalization of Ks in hyperthyroid and lysability in hypothyroid patients.Conclusions
Both hyper- and mild-to-moderate hypothyroidism are associated with prothrombotic plasma fibrin clot phenotype and restoration of euthyroidism improves clot phenotype. Abnormal fibrin clot phenotype might contribute to thromboembolic risk in thyroid disease. 相似文献96.
Ewa Wypasek Agnieszka Branicka Magdalena Awsiuk Jerzy Sadowski Anetta Undas 《Thrombosis research》2014
Introduction
VKORC1 and cytochrome CYP2C9 genetic variants contribute largely to inter-individual variations in vitamin K antagonists (VKAs) dose requirements. Cytochrome P450 4 F2 isoform (CYP4F2), gamma-glutamyl carboxylase (GGCX) and apolipoprotein E (APOE) polymorphisms have been suggested to be of minor significance.Materials and Methods
We sought to assess the impact of those polymorphisms on dose requirements in Central-Eastern European cohort of 479 patients receiving acenocoumarol (n = 260) or warfarin (n = 219).Results
There were no differences between the acenocoumarol and warfarin groups with regard to the gender, age, body mass index and international normalized ratio. The VKORC1 c.-1639A allele carriers required a lower dose of acenocoumarol and warfarin than the non-carriers (28.0 [21.0–35.0] vs. 42.0 [28.0–56.0] mg/week, p < 0.0001; 35.0 [28.0–52.0] vs. 52.0 [35.0–70.0] mg/week, p = 0.0001, respectively). Carriers of *2 and/or *3 variant alleles for CYP2C9 also required a lower dose of warfarin as compared with *1*1 carriers (35.0 [31.5–52.5] vs. 43.8 [35.0–60.2] mg/week, p = 0.02; 35.0 [23.5–35.0] vs. 43.8 [35.0-60.2] mg/week, p < 0.0001, respectively). Similarly, possession of G allele of GGCX c.2084 + 45 polymorphism was associated with lower warfarin dose (35.0 [26.3–39.2] vs. 45.5 [35.0–65.1] mg/week, p = 0.03). No effect of CYP2C9*2,-*3 and GGCX c.2084 + 45G > C polymorphisms on acenocoumarol dosage was observed. Interestingly, carriers of CYP4F2 c.1297A variant required a higher dose of acenocoumarol and warfarin than non-carriers (43.8 [35.0–60.2] vs. 35.0 [35.0–52.5] mg/week, p = 0.01; 35.0 [28.0–52.5] vs. 28.0 [28.0–42.0] mg/week, p = 0.05).Conclusions
We have shown for the first time, that besides VKORC1 and CYP2C9 genetic variants, the CYP4F2 c.1297A and GGCX c.2084 + 45G have a moderate effect on VKAs dose requirements in Slavic population from Central-Eastern Europe. 相似文献97.
The formation of fibrin clots that are relatively resistant to lysis represents the final step in blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in relation to thrombotic disease. In addition, we discuss the implications of fibrin structure for treatment of thrombosis. Fibrin clots composed of compact, highly branched networks with thin fibers are resistant to lysis. Altered fibrin structure has consistently been reported in patients with several diseases complicated by thromboembolic events, including patients with acute or prior myocardial infarction, ischemic stroke, and venous thromboembolism. Relatives of patients with myocardial infarction or venous thromboembolism display similar fibrin abnormalities. Low-dose aspirin, statins, lowering of homocysteine, better diabetes control, smoking cessation, and suppression of inflammatory response increase clot permeability and susceptibility to lysis. Growing evidence indicates that abnormal fibrin properties represent a novel risk factor for arterial and venous thrombotic events, particularly of unknown etiology in young and middle-aged patients. 相似文献
98.
Natorska J Bykowska K Hlawaty M Marek G Sadowski J Undas A 《Heart (British Cardiac Society)》2011,97(24):2023-2028
99.
Nowakowski Tomasz Malinowski Krzysztof Piotr Niżankowski Rafał Iwaniec Teresa Undas Anetta 《Journal of thrombosis and thrombolysis》2019,47(4):540-549
Journal of Thrombosis and Thrombolysis - Hypolysible fibrin clots composed of tightly packed fibers characterize patients with peripheral artery disease (PAD) especially those with critical limb... 相似文献
100.