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451.
Lisia Miglioli Galvão Anna Paula Romero de Oliveira Aline Santos Ibanês Jussimara Monteiro Fernanda Inoue Daniel Chagas Dantas Flavio Sanchez Daniel Wagner Santos Cely Saad Abboud 《The Brazilian journal of infectious diseases》2018,22(3):235-238
Herein we report a fatal case of donor-derived transmission of XDR-resistant carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) in cardiac transplantation. A 59-year-old male patient with non-obstructive hypertrophic cardiomyopathy underwent heart transplantation. On day 5 post-operation, blood cultures from the donor were positive for colistin-resistant carbapenemase-producing K. pneumoniae (ColR KPC-Kp) susceptible only to amikacin. Recipient blood cultures were also positive for ColR KPC-Kp with the same sensitivity profile as the donor isolate with an identical PFGE pattern. The patient was treated with double-carbapenems and amikacin. The patient evolved to pericarditis, osteomyelitis, and pulmonary necrosis, all fragment cultures positive for the same agent. The patient developed septic shock, multiple organ failure and died on day 50 post-transplantation. Based on current microbiological scenario worldwide the possibility of transmitting multidrug resistant (MDR) organisms should be considered. 相似文献
452.
Andrezza Nascimento Bianca Cestari Zychar Rodrigo Pessa Alberto Jos da Silva Duarte Patricia Bianca Clissa Sabri Saeed Sanabani 《Toxins》2022,14(7)
Small RNAs (sRNAs) and microRNAs (miRNAs) are small endogenous noncoding single-stranded RNAs that regulate gene expression in eukaryotes. Experiments in mice and humans have revealed that a typical small RNA can affect the expression of a wide range of genes, implying that small RNAs function as global regulators. Here, we used small RNA deep sequencing to investigate how jararhagin, a metalloproteinase toxin produced from the venom of Bothrops jararaca, affected mmu-miRNAs expression in mice 2 hours (Jar 2hrs) and 24 hours (Jar 24hrs) after injection compared to PBS control. The findings revealed that seven mmu-miRNAs were substantially differentially expressed (p value (p (Corr) cut-off 0.05, fold change ≥ 2) at 2 hrs after jararhagin exposure and that the majority of them were upregulated when compared to PBS. In contrast to these findings, a comparison of Jar 24hrs vs. PBS 24hrs demonstrated that the majority of identified mmu-miRNAs were downregulated. Furthermore, the studies demonstrated that mmu-miRNAs can target the expression of several genes involved in the MAPK signaling pathway. The steady antithetical regulation of mmu-miRNAs may correlate with the expression of genes that trigger apoptosis via MAPK in the early stages, and this effect intensifies with time. The findings expand our understanding of the effects of jararhagin on local tissue lesions at the molecular level. 相似文献
453.
Franko A. Silva Milene S. Ferreira Pedro A. Araújo Samir M. M. Casseb Sandro P. Silva Joaquim P. Nunes Neto Jannifer O. Chiang Jos W. Rosa Junior Liliane L. Chagas Maria N. O. Freitas der B. Santos Leonardo Hernndez Thito Paz Pedro F. C. Vasconcelos Lívia C. Martins 《Viruses》2022,14(11)
Understanding the interaction between viruses and ecosystems in areas with or without anthropic interference can contribute to the organization of public health services, as well as prevention and disease control. An arbovirus survey was conducted at Caxiuanã National Forest, Pará, Brazil, where 632 local residents, 338 vertebrates and 15,774 pools of hematophagous arthropods were investigated. Neutralization antibodies of the Venezuelan Equine Encephalitis virus, subtype IIIA, Mucambo virus (MUCV) were detected in 57.3% and 61.5% of humans and wild vertebrates, respectively; in addition, genomic fragments of MUCV were detected in pool of Uranotaenia (Ura.) geometrica. The obtained data suggest an enzootic circulation of MUCV in the area. Understanding the circulation of endemic and neglected arboviruses, such as MUCV, represents an important health problem for the local residents and for the people living in the nearby urban centers. 相似文献
454.
455.
Antônio Márcio Santana Fernandes Eduardo Santos da Silva Elisânia Fontes Silveira Emília Maria Medeiros de Andrade Belitardo Leonardo Freire Santiago Raphael Chagas Silva Vitor dos Santos Alves Deise Malta Carneiro Fatima Ferreira Alain Jacquet Luis Gustavo Carvalho Pacheco Neuza Maria Alcantara-Neves Carina Silva Pinheiro 《Clinical and experimental allergy》2023,53(2):198-209
456.
Juan María Herrero-Martínez Elena Trigo Miriam Navarro Diana García-Alcázar Irene Carrillo Tania Fernández-López María Calderón-Moreno Rosario Millán-Pérez Juan Cuadros María Velasco Silvia García-Bujalance Manuel Lizasoain Pablo Martín-Rabadán Ana Pérez-Ayala María Flores-Chávez the Working Group on Chagas Disease of Madrid 《Tropical medicine & international health : TM & IH》2023,28(12):912-922