全文获取类型
收费全文 | 6035篇 |
免费 | 305篇 |
国内免费 | 74篇 |
专业分类
耳鼻咽喉 | 107篇 |
儿科学 | 121篇 |
妇产科学 | 112篇 |
基础医学 | 820篇 |
口腔科学 | 488篇 |
临床医学 | 420篇 |
内科学 | 1396篇 |
皮肤病学 | 127篇 |
神经病学 | 581篇 |
特种医学 | 109篇 |
外科学 | 682篇 |
综合类 | 33篇 |
一般理论 | 1篇 |
预防医学 | 629篇 |
眼科学 | 58篇 |
药学 | 454篇 |
中国医学 | 74篇 |
肿瘤学 | 202篇 |
出版年
2023年 | 57篇 |
2022年 | 122篇 |
2021年 | 210篇 |
2020年 | 135篇 |
2019年 | 170篇 |
2018年 | 213篇 |
2017年 | 136篇 |
2016年 | 196篇 |
2015年 | 193篇 |
2014年 | 278篇 |
2013年 | 316篇 |
2012年 | 469篇 |
2011年 | 512篇 |
2010年 | 272篇 |
2009年 | 182篇 |
2008年 | 361篇 |
2007年 | 360篇 |
2006年 | 311篇 |
2005年 | 262篇 |
2004年 | 217篇 |
2003年 | 183篇 |
2002年 | 144篇 |
2001年 | 137篇 |
2000年 | 126篇 |
1999年 | 105篇 |
1998年 | 40篇 |
1997年 | 38篇 |
1996年 | 30篇 |
1995年 | 34篇 |
1994年 | 17篇 |
1993年 | 21篇 |
1992年 | 58篇 |
1991年 | 58篇 |
1990年 | 43篇 |
1989年 | 57篇 |
1988年 | 39篇 |
1987年 | 35篇 |
1986年 | 24篇 |
1985年 | 30篇 |
1984年 | 16篇 |
1983年 | 18篇 |
1978年 | 17篇 |
1975年 | 17篇 |
1974年 | 11篇 |
1973年 | 14篇 |
1971年 | 11篇 |
1970年 | 11篇 |
1969年 | 13篇 |
1968年 | 16篇 |
1967年 | 10篇 |
排序方式: 共有6414条查询结果,搜索用时 15 毫秒
91.
In Argentina, American Cutaneous Leishmaniasis (ACL) extends up to 29°S in the phytogeographic regions of the Yungas (west), Chaco (center) and Paranaense (east). Since the Phlebotominae vectors of this disease in the western Chaco (dry Chaco) are unknown, in the present work, we studied the natural infection in Phlebotominae by PCR-ERFLP and Dot blot in order to incriminate these organisms as potential vectors. Captures with CDC-type traps were performed monthly in the domicile, the peridomicile and the forest in the Municipio Misión Nueva Pompeya, Chaco, Argentina, in two sites with human cases of ACL: Los Pozos (24°54'S, 61°22'W) and Fortín Arenales (24°58'S, 61°21'W), from November 2006 to December 2007. A total of 1702 Phlebotominae were captured: Mygonemyia migonei (83.8%), cortelezzii complex (11.1%), Mycropigomyia peresi (3.3%), Mycropygomy quinquefer (1.2%), Pintomyia torresi (0.2%) and Nyssomyia neivai (0.2%). Although no significant differences were found in species diversity, there were significant differences in abundance between both sites studied. A total of 80 phlebotomine females were analyzed: 50 of the cortelezzii complex and 30 My. migonei. No intestinal flagellates were observed by light microscopy. Two pools of 10 individuals of the cortelezzii complex of the peridomicile and forest of Fortín Arenales were reactive by PCR and Dot blot for Leishmania (Viannia) braziliensis. In Argentina, Evandromyia cortelezzii has been incriminated as a likely vector of ACL because of its abundance in areas of sporadic outbreaks. In the present work, Ev. cortelezzii females were found naturally infected, thus reinforcing the hypothesis that the members of the cortelezzii complex act as vectors of the disease. 相似文献
92.
93.
94.
Dennis J Johnson CY Adediran AS de Andrade M Heit JA Morange PE Trégouët DA Gagnon F 《Blood》2012,119(10):2392-2400
The endothelial protein C receptor (EPCR) limits thrombus formation by enhancing activation of the protein C anticoagulant pathway, and therefore may play a role in the etiology of thrombotic disorders. The rs867186 single-nucleotide polymorphism in the PROCR gene (g.6936A > G, c.4600A > G), resulting in a serine-to-glycine substitution at codon 219, has been associated with reduced activation of the protein C pathway, although its association with thrombosis risk remains unclear. The present study is a highly comprehensive systematic review and meta-analysis, including unpublished genome-wide association study results, conducted to evaluate the evidence for an association between rs867186 and 2 common thrombotic outcomes, venous thromboembolism (VTE) and myocardial infarction (MI), which are hypothesized to share some etiologic pathways. MEDLINE, EMBASE, and HuGE Navigator were searched through July 2011 to identify relevant epidemiologic studies, and data were summarized using random-effects meta-analysis. Twelve candidate genes and 13 genome-wide association studies were analyzed (11 VTE and 14 MI, including 37,415 cases and 84,406 noncases). Under the additive genetic model, the odds of VTE increased by a factor of 1.22 (95% confidence interval, 1.11-1.33, P < .001) for every additional copy of the G allele. No evidence for association with MI was observed. 相似文献
95.
de Andrade DC de Magalhães Souza SC de Carvalho JF Takayama L Borges CT Aldrighi JM Pereira RM 《Rheumatology international》2012,32(6):1549-1553
Bone mass was only previously studied in juvenile dermatomyositis/polymyositis (DM/PM) patients. Therefore, the objective this study was to evaluate the prevalence of osteoporosis and fractures in adult DM/PM. Forty female DM/PM and 78 age-, gender-, and BMI-matched healthy controls were studied. Medical charts and clinical interviews of all patients were evaluated for demographic and clinical data, including disease activity, cumulative doses of glucocorticoid, menarche and menopause age, and fractures. Bone mineral density (BMD) using dual X-ray absorptiometry (DXA) were measured at lumbar spine (L1–L4) and hip. A decreased BMD in lumbar spine [0.902 (0.136) vs. 0.965 (0.141) g/cm2, P?=?0.022] and femoral neck [0.729 (0.12) vs. 0.784 (0.127) g/cm2, P?=?0.027] was observed in patients compared to controls. In addition, osteoporosis was more frequent in patients than in controls in both lumbar spine (20 vs. 3.8%, P?=?0.007) and the femoral neck (27.5 vs. 10.3%, P?=?0.016). Moreover, a high prevalence of fractures was found in patients in comparison to healthy subjects (17.9 vs. 5.1%, P?=?0.040; OR?=?3.92; CI 95%:1.07–14.33). Comparing DM/PM patients with (n?=?17) and without (n?=?23) osteoporosis/fractures, significant differences were observed regarding age [56.8 (11.9) vs. 48.3 (13.2) years, P?=?0.042], weight [62.05 (13.56) vs. 71.51 (11.46) kg, P?=?0.022] and frequency of post menopausal women (94.1 vs. 65.2%, P?=?0.0002). No differences were observed concerning height, lean mass, total fat mass, disease activity, mean value of creatine kinase, cumulative glucocorticoid dose, or bisphosphonate use. Logistic regression analysis revealed a negative association between the presence of osteoporosis/fractures and weight (OR: 0.92, 95% CI: 0.85–0.98; P?=?0.016). This is the first study that analyzed bone mass in adult DM/PM patients and it demonstrated that about one quarter of these patients have osteoporosis/fracture. 相似文献
96.
97.
Pedro Morillas Helder de Andrade Jesus Castillo Juan Quiles Vicente Bertomeu-González Alberto Cordero Estefanía Tarazón Esther Roselló Manuel Portolés Miguel Rivera Vicente Bertomeu-Martínez 《Revista espa?ola de cardiología》2012
Introduction and objectives
To investigate the relationship between inflammatory and apoptotic parameters and the severity and extent of target organ damage in patients with essential hypertension.Methods
We studied 159 consecutive patients with treated essential hypertension. An exhaustive evaluation of damage to heart, kidney, and blood vessels was performed and plasma levels of inflammatory (interleukin 6 and soluble receptor of tumor necrosis factor-alpha type 2) and apoptotic markers (soluble receptor of tumor necrosis factor-alpha type 1 and soluble Fas receptor) were determined. Patients were categorized into four groups: a) no organ damage (33 patients); b) 1 organ damaged (52 patients); c) 2 organs damaged (44 patients), and d) 3 organs damaged (30 patients).Results
Serum levels of interleukin 6, soluble receptor of tumor necrosis factor-alpha type 1 and soluble receptor of tumor necrosis factor-alpha type 2 were higher in patients with target organ damage than in hypertensive patients without organ damage. Increasing levels of these molecules were progressively associated with an increase in the number of organs damaged, and the highest levels were observed in the group with damage to 3 organs (heart, kidney, and blood vessels). There were no differences in soluble Fas receptor levels between groups. Logistic regression analysis showed that age, smoking, diabetes mellitus, abdominal circumference, interleukin 6, and soluble receptor of tumor necrosis factor-alpha type 1 were independently related to the number of target organs damaged.Conclusions
Extensive hypertensive disease with involvement of more target organs was associated with greater inflammatory and apoptotic activation in these hypertensive patients.Full English text available from:www.revespcardiol.org 相似文献98.
A. Foucquier M. Filoche A.A. Moreira J.S. Andrade G. Arbia B. Sapoval 《Respiratory physiology & neurobiology》2013,185(3):625-638
It has recently been shown that the acinus can have a reduced efficiency due to a “screening effect” governed by the ratio of oxygen diffusivity to membrane permeability, the gas flow velocity, as well as the size and configuration of the acinus. We present here a top to bottom calculation of the functioning of a machine acinus at exercise that takes this screening effect into account. It shows that, given the geometry and the breathing dynamics of real acini, respiration can be correlated to a single equivalent parameter that we call the integrative permeability. In particular we find that both and depend on this permeability in a non-linear manner. Numerical solutions of dynamic convection–diffusion equations indicate that only a narrow range of permeability values is compatible with the experimental measurements of and . These permeability values are significantly smaller than those found in the literature. In a second step, we present a new type of evaluation of the diffusive permeability, yielding values compatible with the top to bottom approach, but smaller than the usual morphometric value. 相似文献
99.
Cláudia Monteiro de Andrade Takami Hirono Hotta Marcelo Oliveira Mazzetto Cláudia Maria de Felício Angela Bataglion 《Cranio : the journal of craniomandibular practice》2013,31(1):66-70
This report describes a case of arthrogryposis multiplex congenita and concomitant bruxism with limited mouth opening and pain in the temporomandibular joints (TMJ). A conservative treatment with a myorelaxing splint and physiotherapeutic exercises was prescribed resulting in improvement to the muscular and joint conditions and a reduction in pain. 相似文献