全文获取类型
收费全文 | 373篇 |
免费 | 28篇 |
国内免费 | 7篇 |
专业分类
儿科学 | 8篇 |
妇产科学 | 4篇 |
基础医学 | 27篇 |
口腔科学 | 4篇 |
临床医学 | 40篇 |
内科学 | 91篇 |
皮肤病学 | 33篇 |
神经病学 | 33篇 |
特种医学 | 42篇 |
外科学 | 52篇 |
综合类 | 9篇 |
预防医学 | 17篇 |
药学 | 17篇 |
肿瘤学 | 31篇 |
出版年
2023年 | 7篇 |
2022年 | 3篇 |
2021年 | 17篇 |
2020年 | 9篇 |
2019年 | 16篇 |
2018年 | 12篇 |
2017年 | 7篇 |
2016年 | 12篇 |
2015年 | 13篇 |
2014年 | 15篇 |
2013年 | 17篇 |
2012年 | 21篇 |
2011年 | 27篇 |
2010年 | 20篇 |
2009年 | 12篇 |
2008年 | 19篇 |
2007年 | 21篇 |
2006年 | 11篇 |
2005年 | 9篇 |
2004年 | 15篇 |
2003年 | 6篇 |
2002年 | 10篇 |
2001年 | 7篇 |
2000年 | 5篇 |
1999年 | 3篇 |
1998年 | 13篇 |
1997年 | 4篇 |
1996年 | 8篇 |
1995年 | 7篇 |
1994年 | 10篇 |
1993年 | 7篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 10篇 |
1987年 | 4篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 3篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1967年 | 1篇 |
排序方式: 共有408条查询结果,搜索用时 78 毫秒
61.
62.
63.
64.
Sonia Pernas Marta Gil Ana Benítez Maria Teresa Bajen Fina Climent Maria Jesús Pla Enrique Benito Anna Gumà Cristina Gutierrez Aleydis Pisa Ander Urruticoechea Javier Pérez Miguel Gil Gil 《Annals of surgical oncology》2010,17(3):772-777
Background
The need for axillary lymph node dissection (ALND) in breast cancer patients with sentinel lymph node (SLN) micrometastases remains controversial. The aims of the study were to evaluate the locoregional failure and outcome of breast cancer patients with sentinel node micrometastases who did not undergo completion ALND.Methods
Between November 2000 and December 2006, SLN biopsy was successfully performed in 1178 patients with invasive breast carcinoma. Only patients with macrometastasis (>2 mm) underwent ALND, while patients with negative SLN or micrometastases did not undergo further treatment of the axilla, by either surgery or radiotherapy. Regarding adjuvant therapy decision, patients with SLN-micrometastases (pN1mi) were considered as node-positive patients.Results
Of 1,178 patients, 59 (5%) had micrometastases. Of those with micrometastases, 14 (24%) underwent ALND because the intraoperative study of the SLN yielded a positive result. With a median follow-up of 60 (range, 8–94) months, none of the patients with SLN micrometastases in whom ALND was omitted developed an axillary recurrence, while one patient in whom ALND was performed developed infraclavicular lymph node recurrence. One patient, who declined postoperative breast irradiation, developed breast recurrence and distant metastasis.Conclusions
Breast cancer patients with SLN micrometastases in whom ALND was omitted had a very low locoregional failure rate. This study supports the theory that ALND might be avoided in these patients, providing that adjuvant systemic treatment equal to treatment provided to treat node-positive disease is administered. However, longer follow-up and results of additional prospective studies are needed. 相似文献65.
Pérez-Pérez L Allegue F Caeiro JL Fabeiro JM Pérez Rodríguez A Zulaica A 《Indian journal of dermatology, venereology and leprology》2011,77(2):184-187
The vast majority of mastocytosis appear in childhood, urticaria pigmentosa (UP) and mastocytomas being the most common types. Terms such as "xanthelasmoid mastocytosis", "pseudoxanthomatous mastocytosis" or "nodular mastocytosis" have been introduced in the literature to describe the presence of yellowish papular or nodular lesions. We describe two children with cutaneous mastocytosis showing yellowish lesions in combination with other skin lesions. A 10-year-old girl presented with asymptomatic lesions in her vulva at birth, and developed brownish macules on her trunk years after. An eight-year-old boy presented with multiple yellowish papular lesions on his trunk, neck and limbs coexisting with a few clinically anetodermic lesions. No systemic involvement was found and the skin biopsy confirmed a cutaneous mastocytosis in both cases. The two patients are currently asymptomatic and are being periodically followed up. Mastocytoses may show a variety of clinical lesions, sometimes leading to misdiagnosis. Although there are previous reports, involvement of the mucosae and secondary anetoderma are not common findings in cutaneous mastocytoses. We consider that cutaneous manifestations of mastocytoses compose a clinical spectrum, thus explaining the coexistence of different clinical lesions and the development of uncommon presentations. 相似文献
66.
67.
Marcelo BP Siqueira Deepak Ramanathan Alison K Klika Carlos A Higuera Wael K Barsoum 《World journal of orthopedics》2016,7(1):30-37
Negative-pressure wound therapy(NPWT) has been a successful modality of wound management which is in widespread use in several surgical fields. The main mechanisms of action thought to play a role in enhancing wound healing and preventing surgical site infection are macrodeformation and microdeformation of the wound bed, fluid removal, and stabilization of the wound environment. Due to the devastating consequences of infection in the setting of joint arthroplasty, there has been some interest in the use of NPWT following total hip arthroplasty and total knee arthroplasty. However, there is still a scarcity of data reporting on the use of NPWT within this field and most studies are limited by small sample sizes, high variability of clinical settings and end-points. There is little evidence to support the use of NPWT as an adjunctive treatment for surgical wound drainage, and for this reason surgical intervention should not be delayed when indicated. The prophylactic use of NPWT after arthroplasty in patients that are at high risk for postoperative wound drainage appears to have the strongest clinical evidence. Several clinical trialsincluding single-use NPWT devices for this purpose are currently in progress and this may soon be incorporated in clinical guidelines as a mean to prevent periprosthetic joint infections. 相似文献
68.
Haizea Iribar Ane Jaka Nerea Ormaechea Anna Tuneu Ander Izeta Araika Gutiérrez‐Rivera 《Experimental dermatology》2016,25(11):901-903
Dermal neurofibromas are characteristic of neurofibromatosis type one (NF1), and their developmental origin still unsolved. Although NF1 loss is required for neurofibroma initiation, some features of these benign tumors resemble a skin injury state and cutaneous trauma or other insults might support tumor development. Since adult terminal Schwann cells ensheathing nerve endings are able to dedifferentiate into a progenitor‐like state in response to nerve crushing, we hypothesized that dedifferentiation of NF1?/? Schwann cells could be at the origin of human dermal neurofibromas. In support of this, here we show that CDH19 (a marker specific of Schwann cell precursors) and Schwann cell dedifferentiation marker SOX2 are significantly upregulated in NF1 tumors. We posit that onset of nerve regeneration might have a role in dermal neurofibroma initiation via dedifferentiation of NF1?/? Schwann cells. 相似文献
69.