全文获取类型
收费全文 | 77771篇 |
免费 | 5155篇 |
国内免费 | 336篇 |
专业分类
耳鼻咽喉 | 690篇 |
儿科学 | 2253篇 |
妇产科学 | 1966篇 |
基础医学 | 11166篇 |
口腔科学 | 2446篇 |
临床医学 | 7667篇 |
内科学 | 16623篇 |
皮肤病学 | 1832篇 |
神经病学 | 8220篇 |
特种医学 | 1640篇 |
外科学 | 6654篇 |
综合类 | 501篇 |
一般理论 | 79篇 |
预防医学 | 9183篇 |
眼科学 | 1125篇 |
药学 | 5449篇 |
中国医学 | 270篇 |
肿瘤学 | 5498篇 |
出版年
2024年 | 100篇 |
2023年 | 1004篇 |
2022年 | 1912篇 |
2021年 | 3580篇 |
2020年 | 2121篇 |
2019年 | 2956篇 |
2018年 | 3497篇 |
2017年 | 2312篇 |
2016年 | 2444篇 |
2015年 | 2811篇 |
2014年 | 3541篇 |
2013年 | 4488篇 |
2012年 | 7045篇 |
2011年 | 7170篇 |
2010年 | 3591篇 |
2009年 | 3108篇 |
2008年 | 5012篇 |
2007年 | 4931篇 |
2006年 | 4525篇 |
2005年 | 4104篇 |
2004年 | 3620篇 |
2003年 | 3152篇 |
2002年 | 2713篇 |
2001年 | 298篇 |
2000年 | 203篇 |
1999年 | 298篇 |
1998年 | 478篇 |
1997年 | 387篇 |
1996年 | 291篇 |
1995年 | 237篇 |
1994年 | 189篇 |
1993年 | 165篇 |
1992年 | 112篇 |
1991年 | 92篇 |
1990年 | 78篇 |
1989年 | 76篇 |
1988年 | 65篇 |
1987年 | 51篇 |
1986年 | 51篇 |
1985年 | 45篇 |
1984年 | 58篇 |
1983年 | 56篇 |
1982年 | 48篇 |
1981年 | 50篇 |
1980年 | 41篇 |
1979年 | 21篇 |
1978年 | 19篇 |
1977年 | 22篇 |
1976年 | 14篇 |
1975年 | 16篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
Marjolein C. H. van der Meulen Robert Marcus Laura K. Bachrach Dennis R. Carter 《Journal of orthopaedic research》1997,15(3):473-476
We have developed an analytical model of long bone cross-sectional ontogeny in which appositional growth of the diaphysis is primarily driven by mechanical stimuli associated with increasing body mass during growth and development. In this study, our goal was to compare theoretical predictions of femoral diaphyseal structure from this model with measurements of femoral bone mineral and geometry by dual energy x-ray absorptiometry. Measurements of mid-diaphyseal femoral geometry and structure were made previously in 101 Caucasian adolescents and young adults 9–26 years of age. The data on measured bone mineral content and calculated section modulus were compared with the results of our analytical model of cross-sectional development of the human femur over the same age range. Both bone mineral content and section modulus showed good correspondence with experimental measurements when the relationships with age and body mass were examined. Strong linear relationships were evident for both parameters when examined as a function of body mass. 相似文献
72.
73.
Ana Ortega Ph.D. George Dranitsaris M.Sci.Phm. Jeremy Sturgeon M.D. Heather Sutherland M.Sci. Amit Oza M.D. 《Gynecologic oncology》1997,66(3):454-463
The standard treatment for patients with advanced ovarian cancer (AOC) has been cyclophosphamide and cisplatin (CP). Recently, the results of a large randomized comparative trial demonstrated that the combination of paclitaxel and cisplatin (TP) provided a progression-free survival benefit of 5 months. In this study, a cost–utility analysis was performed from a Canadian health care system perspective to estimate the incremental cost-effectiveness of the TP combination. Twelve AOC patients who received treatment with TP were matched for age and disease stage on a 1-to-2 basis with a CP control. Total hospital resource consumption was then collected for all patients. Treatment preferences were estimated from a cohort of 20 patients and 40 healthy female volunteers using the time trade-off technique. The outcomes were then generated through a decision-analytic model. First-line treatment costs with TP were approximately fourfold greater on a per-cycle basis than the CP alternative (Can$1911 vs Can$459). When progression-free survival benefit and patient treatment preferences were incorporated into the analysis, the results of the decision model revealed an incremental cost between Can$12,000 and Can$24,000 per quality-adjusted progression-free year with the TP protocol. Even though the TP combination has a considerably higher drug acquisition cost, the results of the current analysis suggest that this new chemotherapy regimen does provide patients with substantial quality-adjusted progression-free survival benefit at a reasonable cost to the Canadian health care system. 相似文献
74.
75.
Jesús M. Cesar Ana Vecino Mikel Perez-Vaquero Jos L. Navarro 《European journal of haematology》1993,50(4):234-236
Abstract: Red cell phospholipids (PLs) were assessed in 11 patients with essential thrombocythemia and 5 patients with polycythemia vera. Platelet and plasma PLs were also determined in 10 of these patients, and the results were compared with studies performed in 16 healthy volunteers. The amount of platelet PLs in patients was similar to controls (556 ± 90 nmol/109cells, versus 481 ± 91 nmol/109cells), as was the percentage of the main specimens of these compounds, including phosphatidylserine (11.1 ± 0.8%), which is relevant for platelet procoagulant activity. We did not find differences between red cell PLs of patients (300 ± 60 nmol/109cells), versus controls (289 ± 71 nmol/109cells), and the sphingomyelin/phosphatidylcholine ratio in these cells was the same in both groups (0.75 ± 0.1). Finally, we did not detect any alteration in the amount of plasma PLs specimens. 相似文献
76.
Daphna Mezad Mordechai Hallak Mahmoud Huleihel Limor Gortzak-Uzan Ana Smolin Moshe Mazor 《Magnesium research》2002,15(3-4):247-252
Our objective was to evaluate the effect of intravenous magnesium sulphate administration to patients with preterm labour on maternal serum and amniotic fluid IL-1beta, IL-6, IL-10 and TNFalpha concentrations. Thirty-six patients at 24-34 weeks of singleton gestation, who presented with contractions (> or = 8 in 60 min) had amniocentesis to rule out intrauterine infection. The patients received intravenous MgSO4 for tocolysis. Twenty-six patients had amniocentesis performed before initiation of MgSO4 (controls) while 10 others had the procedure during tocolytic therapy (study patients). Magnesium, IL-1beta, IL-6, TNFalpha and IL-10 concentrations were measured. Study and control groups were statistically compared using Student t test. Mean magnesium levels were significantly higher in the study group (P < 0.01). There were no significant differences between the cytokines levels in maternal serum and in amniotic fluid between the groups. Our results suggest that the mechanism of magnesium as a tocolytic agent may not be mediated via the examined cytokines. 相似文献
77.
Alberto Falchetti Marco Di Stefano Francesca Marini Francesca Del Monte Carmelo Mavilia Debora Strigoli Maria L De Feo Giovan Isaia Laura Masi Antonietta Amedei Federica Cioppi Valentina Ghinoi Susanna Maddali Bongi Giuseppina Di Fede Carmela Sferrazza Giovan B Rini Daniela Melchiorre Marco Matucci-Cerinic Maria L Brandi 《Journal of bone and mineral research》2004,19(6):1013-1017
PDB is genetically heterogeneous. Mutations of the sequestosome1 gene have been reported in sporadic and familial forms of Paget's in patients of French Canadian and British descent. Mutational analyses in different ethnic groups are needed to accurately investigate hereditary diseases. We describe two novel mutations of sequestosome1 in 62 Italian sporadic patients, confirming the role of the encoded protein in this disorder. INTRODUCTION: Paget's disease of bone (PDB) is a relatively common disease of bone metabolism reported to affect up to 3% of whites over 55 years of age. The disorder is genetically heterogeneous, and at present, there is scientific evidence that at least eight different human chromosomal loci are correlated with its pathogenesis. Mutations of the sequestosome1 (SQSTM1) gene were identified as responsible for most of the sporadic and familial forms of Paget in patients of French Canadian and British descent. Such mutations were located at exon 7 and 8 levels, encoding for the ubiquitin protein-binding domain (UBA) and representing a mutational hot spot area. MATERIALS AND METHODS: To verify the involvement of this gene in Italian subjects affected by PDB, we performed mutational analysis in 62 sporadic PDB cases. RESULTS: We described three different mutations at exon 8 level: P392L, already described in the French Canadian population and families predominantly of British descendent, and two novel mutations consisting of the amino acid substitutions M404V and G425R. No significant differences in the clinical history of PDB have been observed in patients with SQSTM1 mutations in respect to those without. CONCLUSIONS: Even though our findings suggest a minor involvement of the SQSTM1 gene in the pathogenesis of sporadic Italian Paget's cases, the identification of different significant mutations within the SQSTM1 gene in unrelated, but clinically similar individuals, offers extremely convincing evidence for a causal relationship between this gene and PDB. Longitudinal studies are needed to assess the penetrance of genotype/phenotype correlations. Our findings confirm the evidence of a clustered mutation area at this level in this disorder. 相似文献
78.
79.
Raquel Carreira Ana Duarte Pedro Monteiro Maria Sancha Santos Ana Cristina Rego Catarina R Oliveira Lino M Gon?alves Luís A Providência 《Revista portuguesa de cardiologia》2004,23(11):1447-1455
Ischemia negatively affects mitochondrial function by inducing the mitochondrial permeability transition (MPT). The MPT is triggered by oxidative stress, which occurs in mitochondria during ischemia as a result of diminished antioxidant defenses and increased reactive oxygen species production. It causes mitochondrial dysfunction and can ultimately lead to cell death. Therefore, drugs able to minimize mitochondrial damage induced by ischemia may prove to be clinically effective. We analyzed the effect of carvedilol, a beta-blocker with antioxidant properties, on mitochondrial dysfunction. Carvedilol decreased levels of TBARS (thiobarbituric acid reactive substances), an indicator of oxidative stress, which is consistent with its antioxidant properties. Regarding cell death by apoptosis, although ischemia did increase caspase-8-like activity, there were no changes in caspase-3-like activity, which is activated downstream of caspase-8; this may indicate that the apoptotic cascade is not activated by 60 minutes of ischemia. We conclude that carvedilol protects ischemic mitochondria by preventing oxidative mitochondrial damage, and, by so doing, it may also inhibit the formation of the MPT pore. 相似文献
80.