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21.
The unusual occurrence of spasticity at birth with symmetrical thalamic damage was found in a male infant delivered at 36 weeks' gestation following an episode of traumatically induced premature labor at 32 weeks. The infant was found to be spastic in flexion with increased stretch reflexes, depressed primitive reflexes, and moderate flexion contractures. Computerized tomographic scans showed bilateral nonenhancing thalamic densities. Neuropathologically, the lateral thalamic nuclei and the red nucleus showed neuron loss, astrocytosis, and, as confirmed by electron microprobe analysis, calcified neurons. The striatum was uninvolved. These findings closely resemble those reported as "symmetrical thalamic degeneration in infancy" and are strongly reminiscent of the pattern of thalamic involvement frequently seen in status marmoratus. It would appear that there is a period during perinatal life in which the lateral thalamus can be rendered vulnerable to hypoxic-ischemic injury, and that the thirty-second week of gestation must be included within this period. 相似文献
22.
HIV-related encephalitis presenting as convulsant disease 总被引:1,自引:0,他引:1
Because of the growing incidence of neurological disorders in HIV-infected patients, an early detection of the disease seems to be of paramount importance, especially in asymptomatic subjects. By using electroencephalography coupled with computerized spectral analysis and "mapping" (EEG-CSA), paroxysmal sharp activity was detected in 26 patients belonging to different stages of HIV infection. Seven of them (27%) were also symptomatic, (table; see text) showing signs of convulsant disease. The presence of focal or generalized paroxysmal activity, often associated with seizures, might suggest an early localization of HIV in cortical structures. 相似文献
23.
OBJECTIVE: To determine whether patients with PD and autonomic failure (AF), manifested primarily with orthostatic hypotension (OH), have a consistent loss of tyrosine hydroxylase (TH) neurons in the rostral ventrolateral medulla (RVLM), similar to that occurring in patients with multiple system atrophy (MSA) and AF, and to determine whether there is loss of nicotinamide, adenine dinucleotide phosphate (NADPH) diaphorase (NADPH-d) RVLM neurons in both groups of patients. METHODS: The numbers of TH and NADPH-d neurons in the RVLM was assessed in brain sections obtained at autopsy from five patients with suspected PD and OH, six patients with MSA, two patients with corticobasal ganglionic degeneration and no AF, and 10 control subjects with no history of neurologic disease. Cell numbers were compared among groups and correlated with their final neuropathologic diagnosis. RESULTS: The number of TH neurons in the RVLM of patients with PD and OH were not significantly different from control subjects, and there were marked individual variations. The TH cell numbers in the RVLM were significantly higher (p < 0.06) in patients with PD than in patients with MSA, despite a similar degree of severity of OH. As a group, patients with PD and OH had reduced numbers of NADPH-d cells in the RVLM compared with control subjects, but again there were marked individual variations. NADPH-d cell numbers were reduced consistently and more markedly in patients with MSA. CONCLUSION: Unlike the case in patients with MSA, the number of TH neurons in the RVLM is highly variable in patients with PD and is unlikely to contribute significantly to the pathophysiology of OH. As a group, patients with PD have reduced numbers of NADPH-d neurons in the RVLM, but some patients had cell counts similar to control subjects. On the other hand, NADPH-d cell depletion in the RVLM is a consistent finding in MSA and may contribute to cardiorespiratory dysfunction in this disorder. 相似文献
24.
Alberti A Dattola A Parisi A Maccarone P Dattola P Celi S Basile M 《Annali italiani di chirurgia》2000,71(6):669-75; discussion 675-6
25.
Cristiana Berti Shirin Elahi Patrick Catalano Zulfiqar A. Bhutta Michael B. Krawinkel Francesca Parisi Carlo Agostoni Irene Cetin Mark Hanson 《Nutrients》2022,14(17)
Adolescent health and well-being are of great concern worldwide, and adolescents encounter particular challenges, vulnerabilities and constraints. The dual challenges of adolescent parenthood and obesity are of public health relevance because of the life-altering health and socioeconomic effects on both the parents and the offspring. Prevention and treatment strategies at the individual and population levels have not been successful in the long term, suggesting that adolescent pregnancy and obesity cannot be managed by more of the same. Here, we view adolescent obese pregnancy through the lens of the social contract with youth. The disruption of this contract is faced by today’s adolescents, with work, social and economic dilemmas which perpetuate socioeconomic and health inequities across generations. The lack of employment, education and social opportunities, together with obesogenic settings, increase vulnerability and exposure to lifelong health risks, affecting their offspring’s life chances too. To break such vicious circles of disadvantage and achieve sustainable solutions in real-world settings, strong efforts on the part of policymakers, healthcare providers and the community must be oriented towards guaranteeing equity and healthy nutrition and environments for today’s adolescents. The involvement of adolescents themselves in developing such programs is paramount, not only so that they feel a sense of agency but also to better meet their real life needs. 相似文献
26.
Topical vancomycin formulation for methicillin-resistant Staphylococcus epidermidis blepharoconjunctivitis 总被引:1,自引:0,他引:1
A B Fleischer D L Hoover J A Khan J T Parisi R P Burns 《American journal of ophthalmology》1986,101(3):283-287
We successfully treated two patients with severe Staphylococcus epidermidis blepharoconjunctivitis by means of a topical vancomycin hydrochloride solution (50 mg/ml) prepared with sterile water. Aqueous vancomycin preparations, however, cause significant ocular irritation probably because of low pH and osmolality values. Solutions prepared with normal saline (5 mg/ml) and phosphate-buffered artificial tears (5 mg/ml and 50 mg/ml) were significantly less irritating and possessed equivalent in vitro antimicrobial activity. Topical vancomycin should be used only when commercially available antibiotics are inadequate. 相似文献
27.
Impaired saccadic eye movement in diabetic patients: the relationship with visual pathways function 总被引:2,自引:0,他引:2
Alessandrini M Paris V Bruno E Giacomini PG 《Documenta ophthalmologica. Advances in ophthalmology》1999,99(1):11-20
The aim of this study was to evaluate whether a correlation existed between saccadic eye movements and visual pathways function
in diabetic patients. Saccadic or fast Eye Movement System (EMS) and Visual Evoked Potentials (VEPs) were assessed in 20 insulin-dependent
diabetic mellitus (IDDM) patients without long-term complications and in stable metabolic control and in 21 age-matched control
subjects. In IDDM patients we observed significantly (p<0.01) longer EMS latency, while EMS velocity and accuracy were similar to those of controls; VEPs showed a significant delay
in N75, P100, N145 latencies and significant reduction of N75-P100 and P100-N145 amplitudes. In IDDM patients no relationships
between EMS and VEP parameters were found. In conclusion, EMS latency delay suggests an impairment of the saccadic eye movement
system, while impaired VEPs may be ascribed to a dysfunction of the visual pathways. The lack of correlation between VEPs
impairment and EMS latency delay suggests that in our IDDM patients the delay of saccadic latency cannot be exclusively related
to a visual pathways dysfuction and could be ascribed to a diffuse neuronal involvement.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
28.
Lorenzo Pistelli MD Giampaolo Vetta MD Antonio Parlavecchio MD Pasquale Crea MD PhD Francesca Parisi MD Michele Magnocavallo MD PhD Rodolfo Caminiti MD Simone Frea MD Alessandro Vairo MD Paolo Desalvo MD Riccardo Faletti MD Marco Gatti MD Giuseppe Dattilo MD Matteo Parollo MD Andrea Di Cori MD Maria Grazia Bongiorni MD Giulia De Santis MD Marco Borgi MD Marco Franzino MD Roberto Licordari MD Giulio Zucchelli MD PhD Giovanni Domenico Della Rocca MD Carla Giustetto MD PhD 《Journal of cardiovascular electrophysiology》2024,35(2):290-300
29.
Gianluca Coppola Ilenia Corbelli Antonio Di Renzo Andrea Chiappiniello Pietro Chiarini Vincenzo Parisi Giorgio Guercini Paolo Calabresi Roberto Tarducci Paola Sarchielli 《The journal of headache and pain》2022,23(1)
IntroductionSeveral functional neuroimaging studies on healthy controls and patients with migraine with aura have shown that the activation of functional networks during visual stimulation is not restricted to the striate system, but also includes several extrastriate networks.MethodsBefore and after 4 min of visual stimulation with a checkerboard pattern, we collected functional MRI in 21 migraine with aura (MwA) patients and 18 healthy subjects (HS). For each recording session, we identified independent resting-state networks in each group and correlated network connection strength changes with clinical disease features.ResultsBefore visual stimulation, we found reduced connectivity between the default mode network and the left dorsal attention system (DAS) in MwA patients compared to HS. In HS, visual stimulation increases functional connectivity between the independent components of the bilateral DAS and the executive control network (ECN). In MwA, visual stimulation significantly improved functional connectivity between the independent component pairs salience network and DAS, and between DAS and ECN. The ECN Z-scores after visual stimulation were negatively related to the monthly frequency of aura.ConclusionsIn individuals with MwA, 4 min of visual stimulation had stronger cognitive impact than in healthy people. A higher frequency of aura may lead to a diminished ability to obtain cognitive resources to cope with transitory but important events like aura-related focal neurological symptoms. 相似文献
30.
F. Dettoni F. Castoldi A. Giai Via S. Parisi D. E. Bonasia R. Rossi 《European journal of trauma and emergency surgery》2011,37(5):511-518