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11.
Van de Perre P Segondy M Foulongne V Ouedraogo A Konate I Huraux JM Mayaud P Nagot N 《The Lancet infectious diseases》2008,8(8):490-497
Recent proof-of-concept randomised controlled trials have shown a causal relation between herpes simplex virus (HSV) type 2 infection and HIV-1 replication in co-infected individuals. We explore the mechanisms that may operate to enhance reciprocal viral replication. Direct interactions could involve HIV-1-related immune deficiency, disruption of mucosal barrier by HSV infection/reactivation, HSV-induced mucosal cell recruitment, transactivation of HIV-1 replication by HSV proteins, and immune modulation by HSV decoys. Indirect interactions might coexist through disturbances of the vaginal flora during HSV shedding and systemic immune activation. In co-infected individuals, suppressive HSV treatment reduces HIV-1 genital and systemic excretion. This finding is a likely result of efficacious prevention of HSV2 reactivations, and perhaps of other herpesviruses. Strategies to control HSV2 and other herpesviruses deserve urgent attention and should become part of the HIV-1 prevention and care package. 相似文献
12.
Georgia R. Gore‐Langton Matthew Cairns Yves Daniel Compaor Issaka Sagara Irene Kuepfer Issaka Zongo Mariken M. de Wit Amadou Barry Modibo Diarra Amadou Tapily Samba Coumare Ismail Thera Frederic Nikiema R. Serge Yerbanga Rosemonde M. Guissou Halidou Tinto Alassane Dicko Daniel Chandramohan Brian Greenwood Jean Bosco Ouedraogo 《Tropical medicine & international health : TM & IH》2020,25(6):740-750
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14.
Diawo Diallo Amadou A. Sall Cheikh T. Diagne Oumar Faye Kathryn A. Hanley Michaela Buenemann Yamar Ba Ousmane Faye Scott C. Weaver Mawlouth Diallo 《The American journal of tropical medicine and hygiene》2014,90(6):1003-1013
During the wet season of 2010, yellow fever virus (YFV) was detected in field-collected mosquitoes in the Kédougou region in southeastern Senegal. During this outbreak, we studied the association of the abundance of YFV-infected mosquitoes and land cover features to try and understand the dynamics of YFV transmission within the region. In total, 41,234 mosquito females were collected and tested for virus infection in 5,152 pools. YFV was detected in 67 pools; species including Aedes furcifer (52.2% of the infected pools), Ae. luteocephalus (31.3% of the infected pools), Ae. taylori (6.0% of the infected pools) and six other species (10.4% of the infected pools) captured in September (13.4%), October (70.1%), and November (16.4%). Spatially, YFV was detected from mosquitoes collected in all land cover classes but mainly, forest canopies (49.2%). Human infection is likely mediated by Ae. furcifer, the only species found infected with YFV within villages. Villages containing YFV-infected mosquitoes were significantly closer to large forests (> 2 ha) than villages in which no infected mosquitoes were detected. 相似文献
15.
I Sagara B Fofana J Gaudart B Sidibe A Togo S Toure K Sanogo D Dembele A Dicko R Giorgi OK Doumbo AA Djimde 《The American journal of tropical medicine and hygiene》2012,87(1):50-56
Artemisinin-based combination therapies (ACTs) are the first-line treatment of uncomplicated malaria. The public health benefit and safety of repeated administration of a given ACT are poorly studied. We conducted a randomized trial comparing artemether-lumefantrine, artesunate plus amodiaquine (AS+AQ) and artesunate plus sulfadoxine-pyrimethamine (AS+SP) in patients 6 months of age and older with uncomplicated malaria in Mali from July 2005 to July 2007. The patient received the same initial treatment of each subsequent uncomplicated malaria episode except for treatment failures where quinine was used. Overall, 780 patients were included. Patients in the AS+AQ and AS+SP arms had significantly less risk of having malaria episodes; risk ratio (RR) = 0.84 (P = 0.002) and RR = 0.80 (P = 0.001), respectively. The treatment efficacy was similar and above 95% in all arms. Although all drugs were highly efficacious and well tolerated, AS+AQ and AS+SP were associated with less episodes of malaria. 相似文献
16.
Idrissa Dieng Marielton dos Passos Cunha Moussa Moïse Diagne Pape Mback Sembne Paolo Marinho de Andrade Zanotto Ousmane Faye Oumar Faye Amadou Alpha Sall 《Viruses》2021,13(1)
Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1–4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and Mali (Western Africa) in 2015–2019, that were analyzed by sequencing the envelope (E) gene. The emergence and the dynamics of DENV-1 in Western Africa were inferred by using maximum likelihood and Bayesian methods. The DENV-1 grouped into a monophyletic cluster that was closely related to those from Southeast Asia. The virus appears to have been introduced directly into Medina Gounass (Suburb of Dakar), Senegal (location probability = 0.301, posterior = 0.76). The introduction of the virus in Senegal occurred around 2014 (95% HPD = 2012.88–2014.84), and subsequently, the virus moved to regions within Senegal (e.g., Louga and Fatick), causing intense outbreaks in the subsequent years. The virus appears to have been introduced in Mali (a neighboring country) after its introduction in Senegal. In conclusion, we present evidence that the outbreak caused by DENV-1 in urban environments in Senegal and Mali after 2015 was caused by a single viral introduction from Asia. 相似文献
17.
Sarra Smati MD Blandine Tramunt MD Matthieu Wargny MD Cyrielle Caussy MD Bénédicte Gaborit MD Camille Vatier MD Bruno Vergès MD Deborah Ancelle MD Coralie Amadou MD Leila A. Bachir MD Olivier Bourron MD Christine Coffin-Boutreux MD Sara Barraud MD Anne Dorange MD Bénédicte Fremy MD Jean-François Gautier MD Natacha Germain MD Etienne Larger MD Stéphanie Laugier-Robiolle MD Laurent Meyer MD Arnaud Monier MD Isabelle Moura MD Louis Potier MD Nadia Sabbah MD Dominique Seret-Bégué MD Patrice Winiszewski MD Matthieu Pichelin PharmD Pierre-Jean Saulnier MD Samy Hadjadj MD Bertrand Cariou MD Pierre Gourdy MD for the CORONADO investigators 《Diabetes, obesity & metabolism》2021,23(2):391-403
18.
Koffi KG Sawadogo D Meite M Nanho DC Tanoh ES Attia AK Sanogo I Sangare A 《The hematology journal : the official journal of the European Haematology Association / EHA》2003,4(5):363-365
T-lymphocyte subsets were studied in two patient groups: (1) 50 patients with homozygous sickle cell anaemia (SCA) (mean age 12 (range 3-32) years old) in good health at the time of the study who showed no infectious complication. (2) 50 patients (mean age 13 (range 4-29) years old) with normal haemoglobin rate. The global response revealed a significant increase in levels of CD3+ (P=0.04) and CD8+ (P=0.04) cells when compared with the control group, there was no significant difference in levels of CD4+ cells (P=0.05) between the two groups. However, there was a relationship between T-cell subpopulation levels and spleen status. The average values of T-cell subsets (CD4+ and CD8+) in patients with SCA-induced splenic defects (asplenic, splenomegaly or splenectomized patients) were significantly reduced when compared to SCA patients with normal spleens and the control groups. These data show that T-cell activity was reduced in patients with splenic defects. A correlation between splenic status and a perturbed host defence system in patients with SCA suggests that monitoring T-cell subsets might have prognostic value in the course of sickle cell disease. 相似文献
19.
Abdourahmane Sow Ousmane Faye Yamar Ba Hampathé Ba Diawo Diallo Oumar Faye Cheikh Loucoubar Mohamed Boushab Yahya Barry Mawlouth Diallo Amadou Alpha Sall 《Emerging infectious diseases》2014,20(2):296-299
After a period of heavy rainfall, an outbreak of Rift Valley fever occurred in southern Mauritania during September–November 2012. A total of 41 human cases were confirmed, including 13 deaths, and 12 Rift Valley fever virus strains were isolated. Moudjeria and Temchecket Departments were the most affected areas. 相似文献
20.
Helen E.D. Burchett Sandra Mounier-Jack Sergio Torres-Rueda Ulla K. Griffiths Pierre Ongolo-Zogo Stephen Rulisa Jean-Marie Edengue Enrique Chavez Yayehirad Kitaw Mitike Molla Mamadou Konate Lawrence Gelmon Washington Onyango-Ouma Mylene Lagarde Anne Mills 《Vaccine》2014