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51.
Amadeus T. Heinz Anton Schönstein Martin Ebinger Jörg Fuchs Beate Timmermann Guido Seitz Christian Vokuhl Marc Münter Kristian W. Pajtler Sabine Stegmaier Thekla von Kalle Christian P. Kratz Gustaf Ljungman Hanna Juntti Thomas Klingebiel Ewa Koscielniak Monika Sparber-Sauer the Cooperative Weichteilsarkom Studiengruppe 《Pediatric blood & cancer》2024,71(1):e30707
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Monika Sparber-Sauer Maximilian Dietzschold Anton Schönstein Amadeus Heinz Christian Vokuhl Kristian W. Pajtler Semi Harrabi Yi-Lan Lin Thekla von Kalle Rudolf Hagen Ruth Ladenstein Bernarda Kazanowska Gustaf Ljungman Thomas Klingebiel Martin Ebinger Ewa Koscielniak Marc Münter Beate Timmermann the CWS Study Group 《Pediatric blood & cancer》2024,71(1):e30742
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Benjamin Tuschy Sebastian Berlit Marc Sütterlin Amadeus Hornemann 《Archives of gynecology and obstetrics》2013,288(2):335-339
Purpose
To investigate patients preferences concerning the duration of hospital stay after gynaecologic laparoscopic surgery due to benign conditions.Methods
This study included women who underwent gynaecologic laparoscopic surgery due to benign conditions between November 2010 and November 2011 at the University Medical Centre Mannheim, Germany. Only women undergoing laparoscopy with four incisions were included. Demographic parameters, type and duration of surgery, perioperative complications and duration of hospital stay were analysed. Women were contacted using a standardized telephone survey. The patients were interviewed regarding the duration of hospital stay and their preferences concerning this matter.Results
A total of 141 patients fitted the inclusion criteria. Eighty-seven of them (61.7 %) were willing to take part in the study; 63 of the women (72.4 %) did not correctly remember the duration of hospital stay in detail; 40 patients (46.0 %) thought it was longer; and 23 of the patients (26.4 %) remembered a shorter stay. For 4 of the 87 women (4.6 %), the duration was too long, and for 14 (16.1 %), the duration of hospital stay after laparoscopy was too short. Women who considered the duration of hospital stay as too long underwent prior abdominal surgery significantly more often.Conclusion
The majority of the patients did not remember the duration of hospital stay correctly. Additionally, more women considered inpatient treatment as too short compered to patients who rated inpatient treatment as too long. 相似文献55.
Hornemann A Bohlmann MK Diedrich K Kavallaris A Kehl S Kelling K Hoellen F 《Archives of gynecology and obstetrics》2011,284(4):875-878
Purpose
To describe the management of a ruptured uterus caused by placenta percreta in the 21st week of gestation. 相似文献56.
Kehl S Brade J Schmidt U Berlit S Bohlmann MK Sütterlin M Siemer J Hornemann A 《Archives of gynecology and obstetrics》2011,284(6):1345-1349
Objective
To evaluate the potential of fetal abdominal circumference (AC) measurement as predictor of perinatal complications in term newborns. 相似文献57.
Amadeus Hornemann Wolf-Dietrich Husstedt Friederike Hoellen Axel Kamischke Klaus Diedrich Michael K. Bohlmann 《Archives of gynecology and obstetrics》2011,283(6):1309-1312
Objective
Acetic acid tests are commonly performed for colposcopic evaluation of the cervix. However, it is unclear whether the acetic acid influences normal Papanicolaou (Pap) smear results. 相似文献58.
Hanna Bonnekoh Carolina Vera Angela AbadPerez Silke Radetzki Martin Neuenschwander Edgar Specker Niklas Amadeus Mahnke Stefan Frischbutter Eicke Latz Marc Nazar Jens v. Kries Marcus Maurer Jrg Scheffel Karoline Krause 《Clinical and translational allergy》2021,11(5)
BackgroundThe pathogenesis of contact dermatitis, a common inflammatory skin disease with limited treatment options, is held to be driven by inflammasome activation induced by allergens and irritants. We here aim to identify inflammasome‐targeting treatment strategies for irritant contact dermatitis.MethodsA high content screen with 41,184 small molecules was performed using fluorescent Apoptosis associated speck‐like protein containing a CARD (ASC) speck formation as a readout for inflammasome activation. Hit compounds were validated for inhibition of interleukin (IL)‐1β secretion. Of these, the approved thiuramdisulfide derivative disulfiram was selected and tested in a patch test model of irritant contact dermatitis in 25 healthy volunteers. Topical application of disulfiram, mometasone or vehicle was followed by application of sodiumdodecylsulfate (SDS) for 24 h each. Eczema induction was quantified by mexameter and laser speckle imaging. Corneocyte sampling of lesional skin was performed to assess inflammasome‐mediated cytokines IL‐1β and IL‐18.ResultsDisulfiram induced a dose‐dependent inhibition of ASC speck formation and IL‐1β release in cellular assays in vitro. In vivo, treatment with disulfiram, but not with vehicle and less mometasone, inhibited SDS‐induced eczema. This was demonstrated by significantly lower erythema and total perfusion values assessed by mexameter and laser speckle imaging for disulfiram compared to vehicle (p < 0.001) and/or mometasone (p < 0.001). Also, corneocyte IL‐18 levels were significantly reduced after application of disulfiram compared to vehicle (p < 0.001).ConclusionWe show that disulfiram is a dose‐dependent inhibitor of inflammasome pathway activation in vitro and inhibitor of SDS‐induced eczema in vivo. Topical application of disulfiram represents a potential treatment option for irritant contact dermatitis. 相似文献
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