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141.
Duygu Geler Kulcu Berfu Akbas Beyza Citci Mutlu Cihangiroglu 《The journal of spinal cord medicine》2009,32(2):198-203
Background/Objective:
To report manifestation of autonomic dysreflexia (AD) in a man with multiple sclerosis (MS).Design:
Case report.Findings:
A young man presented with a history of several admissions to the emergency department with complaints of hypertensive attacks, palpitations, difficulty in breathing, headaches, and flushing. The attacks were attributed to a previously diagnosed anxiety disorder. Onset of numbness of the left leg numbness prompted a more thorough study, which showed evidence of MS. AD was suspected as the cause of his recurrent attacks of hypertension. Bladder distension was identified as the cause of AD, and his hypertensive attacks were controlled by management of neurogenic bladder.Conclusions:
This report emphasizes that AD can occur in MS. Somatic symptoms warrant thorough investigation before attributing them to psychosomatic causes. 相似文献142.
The discovery of cannabinoids, with the well-known stimulatory effect of Cannabis sativa on appetite, has offered a new drug target for obesity treatment. Cannabinoids act on two different receptors: CB1 receptors which are sited in the brain and many peripheral tissues, and CB2 receptors which are primarily found in immune system cells. Cannabinoid receptor antagonists act centrally by blocking CB1 receptors, thereby reducing food intake. Moreover, they probably also act peripherally by increasing thermogenesis and therefore energy expenditure, as has been suggested by animal experiments. Despite these promising mechanisms of action, recent clinical studies examining the effect of the two CB1 receptor antagonists rimonabant and taranabant showed that the attained weight loss did not exceed that attained with other currently approved anti-obesity medications. Moreover, potentially severe psychiatric adverse effects limit their clinical use. As several new CB1 receptor antagonists are presently undergoing development, it remains to be elucidated to what extent they differ in terms of efficacy and safety. This review primarily discusses how close cannabinoid receptor antagonists are to the ideal anti-obesity drug, with respect to their mechanisms of action, clinical effectiveness and safety. 相似文献
143.
Mine Durusu Tanriover S. Gul Oz Tumay Sozen Alpaslan Kilicarslan Gulay Sain Guven 《The spine journal》2009,9(4):e20-e24
Background contextPregnancy- and lactation-associated osteoporosis is an uncommon condition that may be a consequence of preexisting low bone density, loss of bone mineral content during pregnancy, and increased bone turnover.PurposeTo present a case of severe osteoporosis associated with pregnancy and lactation and its treatment protocol.Study design/settingA tertiary care hospital.Patient sampleA young female after twin pregnancy presenting with severe osteoporosis.MethodsThe diagnosis was done on the basis of bone mineral density (BMD) measurement. The patient was treated with first alendronate and then strontium ranelate. She was considered as a candidate for kyphoplasty.ResultsA dramatic increase in the BMD and palliation of back pain were observed.ConclusionsStrontium ranelate may be a new alternative in the treatment of pregnancy- and lactation-associated osteoporosis. 相似文献
144.
Hasan Onal Erdal Adal Seçil Alpaslan Atilla Ersen Ahmet Aydin 《European journal of nutrition》2010,49(7):395-400
Background
Vitamin D deficiency in childhood is a significant problem worldwide. Religious, social customs, and lack of food fortification were significant hurdles in the way of the rickets scourge. Recent data support a serum level of 25(OH)D level >40 ng/mL as the appropriate standard to achieve to prevent rickets. Herein, the current approaches of preventing rickets and optimal level of different vitamin D intakes were evaluated. 相似文献145.
Huseyin Erdinc Besikcioglu Gulistan Sanem Sarıbas Candan Ozogul Meral Tiryaki Sevtap Kilic Ferda Alpaslan Pınarlı Ozlem Gulbahar 《Taiwanese journal of obstetrics & gynecology》2019,58(1):53-59
Objective
Chemotherapy causes depletion of primordial follicles that leads to premature ovarian failure in female cancer survivals. We investigated the effect of bone marrow derived mesenchymal (BMMSCs) and ovarian stromal stem cells (OSSCs) on follicle maturation in chemotherapy induced ovarian failure.Material and methods
Thirty six Wistar Albino female rats were divided into three groups. Cyclophosphamide at a dose of 200 mg/kg was intraperitoneally (IP) given to the rats in all groups two times. 4 × 106 BMMSCs (IP) was injected to the group-2 and 4 × 106 OSSCs (IP) was injected to the group-3. Serum Anti-Müllerian Hormone (AMH) levels was determined with ELISA and primordial follicles were counted for investigation of primordial follicle reserve. The ovarian structure were evaluated histomorphologically. Localization of BrdU labeled stem cells, the expression of the cell cycle regulator p34Cdc2, gap junction protein p-connexin43 and intraovarian regulators of folliculogenesis Bone Morphogenic Protein 6 and 15 (BMP-6 and BMP-15) were investigated by immunohistochemistry.Results
The immunstaining of BMP-6 was higher in oocytes of group-3 more than group-1 and group-2. The immunpositivity of p34cdc2 and BMP-15 were also higher in follicular cells of group-3 than the other groups. The presence of p-connexin43 in group-3 was determined more than group-1 and group-2. The ovarian follicles with normal histological structure were observed just in group-3. Although, The AMH levels were decreased in rats from all groups at the end of experimental procedure the primordial follicle counts in group-3 was significantly higher than group-1.Conclusion
Our findings suggest that OSSCs have more protective effect on follicle maturation than BMMSCs in cyclophosphamide induced ovarian damage. 相似文献146.
Multicentric giant cell tumor is a rare variant of giant cell tumor. In this case, we report a case of a 15-year-old female patient with synchronous type of multicentric giant cell tumor. 相似文献
147.
Twenty-three hips of 23 Legg-Calvé-Perthes-disease (LCPD) patients treated with abduction orthosis and 28 hips of 25 non-braced LCPD patients were evaluated radiologically retrospectively. The mean age of the brace group was 6.82 years and the mean follow-up was 12.30 years. The mean age and mean follow-up were 7.03 and 17.85 years for non-braced patients, respectively. The hips were evaluated according to lateral pillar classification. There were eight Herring A, 15 Herring B and five Herring C hips in the non-braced patients group; and there were five Herring A, 11 Herring-B and seven Herring C hips in the brace group. The groups were similar in terms of mean age, mean follow-up, sex distribution and lateral pillar grade. Patients' end results were evaluated according to Stulberg classification. All Herring A patients healed with Stulberg class 1 or 2, either braced or non-braced. Fifty-three percent of non-braced hips and 65% of the hips treated with brace healed with satisfactory radiological outcome. There were no significant differences between the groups in terms of end result. The overall results of this study suggest that Herring's lateral pillar classification is a useful system for the prediction of the long-term outcome of the disease and that there was no significant difference between the braced and non-braced patients in terms of radiological end result. 相似文献
148.
Mice overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid 总被引:5,自引:0,他引:5
Dedeoglu A Ferrante RJ Andreassen OA Dillmann WH Beal MF 《Experimental neurology》2002,176(1):262-265
Heat shock proteins (HSPs) are induced in response to oxidative stress, hypoxia-ischemia, and neuronal injury and play a protective role. Malonate and 3-nitropropionic acid (3-NP) are well-characterized animal models of Huntington's Disease (HD). They inhibit succinate dehydrogenase, inducing mitochondrial dysfunction, which triggers the generation of superoxide radicals, secondary excitotoxicity, and apoptosis. In this study, we examined whether the 70-kDa heat shock protein (HSP-70) is protective against neurotoxicity induced by malonate and 3-NP. Homozygous and heterozygous HSP-70 overexpressing mice (HSP-70+/+, HSP-70+/-) and wild-type controls received 3-NP or malonate and striatal lesion sizes were evaluated by stereology. Compared to HSP-70+/+ and HSP-70+/-, wild-type controls showed significantly larger striatal lesions following 3-NP or malonate injections. These findings support the idea that HSP-70 has a neuroprotective role that may be useful in the treatment of neurodegenerative diseases. 相似文献
149.
150.
Cytochrome C and caspase-9 expression in Huntington's disease 总被引:7,自引:0,他引:7
Kiechle T Dedeoglu A Kubilus J Kowall NW Beal MF Friedlander RM Hersch SM Ferrante RJ 《Neuromolecular medicine》2002,1(3):183-195
There is increasing evidence implicating apoptosis-mediated cell death in the pathogenesis of neurodegenerative diseases.
One important event in the apoptotic cascade is the release of cytochrome c by mitochondria into the cytoplasm, activating
caspase-9, leading to the subsequent activation of downstream executioner caspases. In the present study, we examined the
distribution of cytochrome c and caspase-9 in Huntington’s disease (HD) patients and in a transgenic model of HD (R6/2 line).
Neuronal cytochrome c immunoreactivity increased with neuropathological severity in HD patients. Concomitant with this finding,
Western-blot analysis showed a shift in the distribution of cytochrome c from the mitochondrial to the cytosolic fraction
with incremental cytosolic expression associated with greater striatal degeneration. Active caspase-9 immunoreactivity was
present in both HD striatal neurons and in Western blots of severe-grade specimens. Similar findings were observed in the
R6/2 mice. There was a temporal increase in expression and shift of cytochrome c from the mitochondrial to the cytosolic fraction
from 4–13 wk of age. Activated caspase-9 and caspase 3 activities were present only at endstage disease. Although the present
results provide evidence that key components of the intrinsic mitochondrial apoptotic pathway are activated in both HD patients
and a transgene murine model of HD, these phenomena are prominent in only severe neuropathological grades in HD patients and
HD mice, suggesting that apoptosis may play a greater role in neuronal death at endstage disease. 相似文献