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931.
F. Javier Melgosa Ramos MD Víctor González-Delgado MD José María Sánchez Motilla MD Galarreta Pascual Marta MD Almudena Mateu Puchades PhD Santos Alarcón Sergio MD 《The Australasian journal of dermatology》2023,64(4):e361-e364
This was an observational and retrospective multicentre study conducted on adolescents and adults diagnosed with moderate-to-severe atopic dermatitis (AD) and treated with upadacitinib. Disease severity was measured by Eczema Area and Severity Index (EASI), validated investigator global assessment for AD and pruritus Numerical Rating Scale (NRS) at baseline and Weeks 4, 16, 24 and 52 (when available). Twenty-one patients were included. All patients had previously received topical and systemic corticosteroids. Rapid response to upadacitinib was observed: Mean (SD) EASI score was 19.8 (6.5) at baseline, and 3.1 (4.2), 0.9 (1.4), 0.6 (0.6) and 0.6 (0.6) at the Weeks 4, 16, 24 and 52, respectively. Itch was controlled at Week 4 in all patients (mean [SD] NRS score 7.6 [1.9] baseline, 1.5 [1.3] W4). Severe infections or major adverse cardiovascular events were not reported. We highlight effectiveness and rapid response of upadacitinib in achieving itch control even in long-standing recalcitrant cases. 相似文献
932.
Jorge Infante-Menéndez Andrea R. López-Pastor Tamara González-Illanes Paula González-López Raquel Huertas-Lárez Esther Rey Águeda González-Rodríguez Carmelo García-Monzón Nikita P. Patil Melina Vega de Céniga Aaron B. Baker Almudena Gómez-Hernández Oscar Escribano 《Liver international》2023,43(8):1714-1728
Background and Aims
The molecular mechanisms driving non-alcoholic fatty liver disease (NAFLD) are poorly understood; however, microRNAs might play a key role in these processes. We hypothesize that let-7d-5p could contribute to the pathophysiology of NAFLD and serve as a potential diagnostic biomarker.Methods
We evaluated let-7d-5p levels and its targets in liver biopsies from a cross-sectional study including patients with NAFLD and healthy donors, and from a mouse model of NAFLD. Moreover, the induction of let-7d-5p expression by fatty acids was evaluated in vitro. Further, we overexpressed let-7d-5p in vitro to corroborate the results observed in vivo. Circulating let-7d-5p and its potential as a NAFLD biomarker was determined in isolated extracellular vesicles from human plasma by RT-qPCR.Results
Our results demonstrate that hepatic let-7d-5p was significantly up-regulated in patients with steatosis, and this increase correlated with obesity and a decreased expression of AKT serine/threonine kinase (AKT), insulin-like growth factor 1 (IGF1), IGF-I receptor (IGF1R) and insulin receptor (INSR). These alterations were corroborated in a NAFLD mouse model. In vitro, fatty acids increased let-7d-5p expression, and its overexpression decreased AKT, IGF-IR and IR protein expression. Furthermore, let-7d-5p hindered AKT phosphorylation in vitro after insulin stimulation. Finally, circulating let-7d-5p significantly decreased in steatosis patients and receiver operating characteristic (ROC) analyses confirmed its utility as a diagnostic biomarker.Conclusions
Our results highlight the emerging role of let-7d-5p as a potential therapeutic target for NAFLD since its overexpression impairs hepatic insulin signalling, and also, as a novel non-invasive biomarker for NAFLD diagnosis. 相似文献933.
José Ignacio Martínez-Montoro Javier Benítez-Porres Francisco J. Tinahones Almudena Ortega-Gómez Mora Murri 《Obesity reviews》2023,24(10):e13599
The increasing prevalence of metabolic syndrome is associated with major health and socioeconomic consequences. Currently, physical exercise, together with dietary interventions, is the mainstay of the treatment of obesity and related metabolic complications. Although exercise training includes different modalities, with variable intensity, duration, volume, or frequency, which may have a distinct impact on several characteristics related to metabolic syndrome, the potential effects of exercise timing on metabolic health are yet to be fully elucidated. Remarkably, promising results with regard to this topic have been reported in the last few years. Similar to other time-based interventions, including nutritional therapy or drug administration, time-of-day-based exercise may become a useful approach for the management of metabolic disorders. In this article, we review the role of exercise timing in metabolic health and discuss the potential mechanisms that could drive the metabolic-related benefits of physical exercise performed in a time-dependent manner. 相似文献
934.
Rodolfo David Palacios-Diaz Antonio Sahuquillo-Torralba Vicenç Rocamora-Durán Blanca de Unamuno-Bustos Miguel Salavert-Lleti Sergio Santos-Alarcón Adriana Quintero Joan Garcías-Ladaria Aina Vila-Payeras Alvaro Martínez-Doménech Almudena Mateu-Puchades Cristina Nadal-Lladó Rafael Botella-Estrada 《Journal der Deutschen Dermatologischen Gesellschaft》2023,21(5):473-480
935.
José Luis González Gutiérrez Mari Carmen Écija Gallardo Borja Matías Pompa Miriam Alonso Fernández Juan Carlos Pacho Hernández Almudena López López 《Stress and health》2023,39(2):429-448
The rapid spread of COVID-19 caused many countries to decide to enter full lockdown, a circumstance that impacted all aspects of life, including mental health. The present longitudinal study aimed to analyse how stressors and uplifts of confinement were linked to psychological symptoms at three different time points: during the full lockdown (wave 1), after the gradual lifting of restrictions (wave 2) and after confinement (wave 3). The sample was made up by one hundred and twenty academic and administrative staff from a big University in Spain, they all completed an online survey. Results showed that psychological status did not change over time, but a significant interindividual variability was found throughout. Some stressors were only linked to symptoms at wave 1, but others maintained their associations during waves 2 and 3. Uplifts were, for the most part, inversely (and exclusively) linked to symptoms at wave 1. However, some of them, although enjoyable, were paradoxically linked to worse mental health at wave 1, and even at waves 2 and 3. These findings highlight the importance of providing preventive psychological strategies for mental distress before, during and after confinement. 相似文献
936.
Juan Ocaña Paula Pastor Ander Timoteo Manuel Mariano Diez-Alonso Fernando de la Portilla Carmen Cagigas María Labalde-Martínez Eloy Espin Paula Dujovne Marta Nieto Manuel González Rodrigo Sanz Marta Pascual Ignacio Aguirre-Allende Jorge Cervera Virginia Jiménez-Carneros Hector Guadalajara Alvaro García-Granero José María Fernández-Cebrián Javier Die-Trill collaborators from the RIALTCOT Study Collaborative Work 《Colorectal disease》2023,25(3):420-430
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938.