全文获取类型
收费全文 | 263篇 |
免费 | 18篇 |
国内免费 | 50篇 |
专业分类
儿科学 | 3篇 |
妇产科学 | 14篇 |
基础医学 | 56篇 |
口腔科学 | 2篇 |
临床医学 | 44篇 |
内科学 | 77篇 |
皮肤病学 | 4篇 |
神经病学 | 8篇 |
特种医学 | 1篇 |
外科学 | 21篇 |
综合类 | 22篇 |
预防医学 | 7篇 |
眼科学 | 6篇 |
药学 | 51篇 |
中国医学 | 1篇 |
肿瘤学 | 14篇 |
出版年
2021年 | 2篇 |
2020年 | 2篇 |
2019年 | 9篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 7篇 |
2015年 | 7篇 |
2014年 | 3篇 |
2013年 | 14篇 |
2012年 | 11篇 |
2011年 | 13篇 |
2010年 | 15篇 |
2009年 | 27篇 |
2008年 | 11篇 |
2007年 | 29篇 |
2006年 | 18篇 |
2005年 | 21篇 |
2004年 | 16篇 |
2003年 | 11篇 |
2002年 | 10篇 |
2001年 | 18篇 |
2000年 | 11篇 |
1999年 | 7篇 |
1998年 | 11篇 |
1997年 | 9篇 |
1996年 | 6篇 |
1995年 | 6篇 |
1994年 | 4篇 |
1993年 | 9篇 |
1992年 | 6篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1988年 | 5篇 |
1987年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有331条查询结果,搜索用时 672 毫秒
81.
Intraoperative anti-thymocyte globulin-Fresenius (ATG-F) administration as induction immunosuppressive therapy in kidney transplantation 总被引:5,自引:0,他引:5
We reviewed 43 adult kidney transplant patients (32 males and 11 females, 14-68 years of age) performed at our center between July 1999 and February 2002. Donors (39 males and 4 females) comprised two cadaverics, five living-related and 36 living-unrelated; age 18-44 years. Indications for kidney transplantation (KT) were: chronic glomerulonephritis (8), re-transplantation (4) and chronic pyelonephritis (3); kidney disease was unknown in 15 cases. ATG-F was given as a single intra-operative bolus induction therapy in 26 patients; extended ATG-F dose was given in 17 patients because of a high sensitization status, slow graft function (SGF) or development of calcineurin inhibitors toxicity. ATG-F was stopped in seven out of 17 patients because of thrombocytopenia or severe anemia. ATG-F-related fever occurred in six patients. Acute rejection (AR) occurred in eight patients (18%) 5-11 days post-KT. ATG-F was given in three steroid-resistant AR. Infection occurred in 19 patients (44%) for a total of 32 infectious episodes comprising 24 bacterial infections (nine urinary, seven catheter-related and three respiratory), six viral infections (five CMV and one herpes) and two fungal infections (one pulmonary aspergillosis and one catheter-related candidiasis). The hospital stay was 8-75 days for a median of 13 days. The mean serum creatinine upon discharge, at 1 and 6 months after KT were: 2.04+/-0.37, 1.43+/-0.16 and 1.29+/-0.08, respectively. One patient lost his graft on day 9 because of graft microthrombi related to Factor V-Leiden mutation. The 6 months actuarial patient and graft survival were 100 and 97.6%, respectively. ATG-F as a bolus therapy is an effective and safe induction treatment in KT. 相似文献
82.
We reviewed two groups of kidney transplant patients receiving neoral (Group I, 27 patients) or FK506 (Group II, 25 patients) as maintenance immunosuppression between December 1998 and May 2002. The recipient and donor demographics and induction therapy were comparable in both groups except for more highly sensitized patients in Group II. Acute rejection (AR) rate and timing were similar in both groups except for more steroid resistant AR in Group II (P=0.04). Infections rate was similar in both groups (25.9% in Group I and 36% in Group II; P=N.S.), but there were less viral infections in Group I (0%) than Group II (29%; 4 CMV). CMV infections were related to the presence in Group II of more CMV-negative recipients getting kidneys from CMV-positive donors. The metabolic profile was comparable between the two groups, except for a better HDL in Group II (48.2+/-7.6) versus Group I (45+/-2.2; P=0.021). Mean serum creatinine levels upon discharge, at 1, 3 and 6 months were: 1.62+/-0.32, 1.4+/-0.17, 1.39+/-0.14 and 1.4+/-0.14 in Group I and 2.15+/-0.5, 1.48+/-0.23, 1.41+/-0.21 and 1.23+/-0.11 in Group II, respectively. The 6 months actuarial patient and graft survival were identical in both groups (100 and 100%). Both calcineurin inhibitors are effective and safe in KT. The higher rate of AR in Group II was related to more highly sensitized patients and the higher CMV infections was due to the presence of more CMV-negative recipients receiving kidneys from CMV-positive donors. The same study will be continued to evaluate the long term effects of both drugs. 相似文献
83.
Mtiraoui N Zammiti W Fekih M Hider S Almawi WY Mahjoub T 《Fertility and sterility》2007,88(5):1458-1461
The prevalence of lupus anticoagulant (LAC), anticardiolipin (ACA), anti-beta(2) glycoprotein I (beta(2)GPI), and antiannexin V antibodies were determined in 200 recurrent spontaneous abortion (RSA) patients and 200 age-matched control women. ACA IgG was associated with early, while antiannexin V IgG and LAC were associated with late, and ACA IgG, antiannexin V IgG, and LAC were associated with combined early + late RSA, thereby recommending inclusion of their screening in RSA workout. 相似文献
84.
W Y Almawi M G Murphy A Ogbaghebriel B L Pope 《International journal of immunopharmacology》1987,9(6):697-704
The M1-A5 cell line, isolated from the spleen of a tumor bearing mouse, has been shown to secrete a suppressor cell-inducing factor (SIF) which activates suppressor cells from the spleen cells of unprimed mice. In an earlier publication we demonstrated that prostaglandins of the E series (PGE) regulate the release of SIF from M1-A5 cells. In the present study we provide evidence that cyclic adenosine 3',5'-monophosphate (cyclic AMP) is the second messenger for PGE in regulating the release of SIF from M1-A5 cells. Our data show that PGE1 and PGE2 stimulate cyclic AMP production by M1-A5 cells. Furthermore, we show that drugs which: (1) elevate cyclic AMP levels (dibutyryl (db) cyclic AMP), (2) inhibit the breakdown of cyclic AMP (theophylline), or (3) stimulate adenylate cyclase (isoproterenol and histamine) all restored suppressor cell activation by M1-A5 cells in which PG synthesis had been blocked by acetylsalicylic acid (ASA). Thus, these results are consistent with the hypothesis that cyclic AMP is the second messenger for PGE in modulating the release of SIF from M1-A5 cells. 相似文献
85.
86.
87.
关附甲素的结构简化物及抗心律失常活性 总被引:1,自引:0,他引:1
为寻找活性高、毒副作用小的抗心律失常新药,以关附甲素为先导物进行结构简化,共设计合成了1-苯基-3-烷胺基-1,2-丙二醇类化合物14个和吲哚嗪类化合物9个。对抗氯仿诱发小鼠心律失常试验表明,Ⅰ1,Ⅰ2,Ⅰ3,Ⅰ7,Ⅰ8,Ⅰ14和Ⅱ27个化合物有较显著的抗心律失常活性,其中Ⅰ2,Ⅰ3,Ⅰ7和Ⅰ8抗心律失常活性优于关附甲素。 相似文献
88.
高位小切口手术治疗精索静脉曲张 总被引:4,自引:0,他引:4
目的探讨精索静脉曲张患者高位小切口手术治疗的效果。方法回顾性分析了2005~2006年收治的49例精索静脉曲张患者的病情、治疗及临床效果的有关资料。结果手术治疗49例,仅2例症状体征改变不明显。结论精索静脉曲张患者采用高位小切口手术治疗效果明显,且符合微创要求。 相似文献
89.
Abou-Jaoude MM Najm R Shaheen J Nawfal N Abboud S Alhabash M Darwish M Mulhem A Ojjeh A Almawi WY 《Transplantation proceedings》2005,37(7):3025-3028
The effects of the calcineurin inhibitors tacrolimus (FK506) and cyclosporine (Neoral) on graft survival, function, and metabolic profile were evaluated in 69 patients receiving Neoral (group 1) and 54 patients receiving FK506 (group 2) for maintenance immunosuppression following kidney transplantation. Recipient and donor demographics and induction therapy were comparable, except for a higher number of sensitized patients in group 2 (n = 13). Acute rejection timing, severity, and infection rates and types were similar in both groups. During hospitalization, at 6 months, and at 1 year following transplantation, no significant differences were noted between groups in fasting glucose, serum cholesterol levels, triglyceride levels, or need for insulin or antihypertensive therapy. Mean serum creatinine levels on discharge (1.42 mg/dL +/- 0.14 vs 1.68 mg/dL +/- 0.3), at 1 month (1.45 mg/dL +/- 0.1 vs 1.39 mg/dL +/- 0.11), 3 months (1.46 mg/dL +/- 0.09 vs 1.32 mg/dL +/- 0.14), and 1 year (1.29 mg/dL +/- 0.08 vs 1.19 mg/dL +/- 0.09), but not at 6 months (1.42 +/- 0.37 vs 1.10 +/- 0.07; P = .001), were comparable between groups. The 1-year patient and graft survival rates were 98.3% for group 1 and 94.5% for group 2. When evaluated for acute rejection, infection, and metabolic differences, we conclude that both tacrolimus and cyclosporine are effective and safe calcineurin inhibitors for short-term use in kidney transplantation. A similar study is proposed to evaluate the long-term effects of both agents. 相似文献
90.
Musharrafieh UM Jamaleddine GW Taher AT Almawi WY Tabbara ZA 《Journal of thrombosis and thrombolysis》2004,17(2):133-137
A case of progressive shock and multisystem organ failure is reported for an 18 year old Lebanese woman, clinically diagnosed as toxic shock syndrome (TSS). The patient developed cough and dyspnea during hospitalization; chest CT angiography revealed thromboembolism of the pulmonary artery. CBC analysis showed leukocytosis with a white cell count (WCC) with a marked increase in PT and PTT coupled with reduced protein S, antithrombin III, and protein C levels. The patient improved gradually and was discharged from the hospital 7 days later on oral anticoagulation, and was followed up for six months with no disease recurrence or complications. To our knowledge, this is the first reported case in the literature of toxic shock syndrome associated with pulmonary thromboembolism. 相似文献