全文获取类型
收费全文 | 3313篇 |
免费 | 218篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 83篇 |
妇产科学 | 54篇 |
基础医学 | 382篇 |
口腔科学 | 175篇 |
临床医学 | 318篇 |
内科学 | 631篇 |
皮肤病学 | 126篇 |
神经病学 | 253篇 |
特种医学 | 90篇 |
外科学 | 441篇 |
综合类 | 60篇 |
预防医学 | 253篇 |
眼科学 | 202篇 |
药学 | 300篇 |
中国医学 | 31篇 |
肿瘤学 | 139篇 |
出版年
2024年 | 7篇 |
2023年 | 52篇 |
2022年 | 117篇 |
2021年 | 229篇 |
2020年 | 128篇 |
2019年 | 184篇 |
2018年 | 199篇 |
2017年 | 144篇 |
2016年 | 159篇 |
2015年 | 140篇 |
2014年 | 187篇 |
2013年 | 224篇 |
2012年 | 348篇 |
2011年 | 323篇 |
2010年 | 175篇 |
2009年 | 141篇 |
2008年 | 171篇 |
2007年 | 189篇 |
2006年 | 129篇 |
2005年 | 114篇 |
2004年 | 68篇 |
2003年 | 51篇 |
2002年 | 41篇 |
2001年 | 4篇 |
2000年 | 5篇 |
1999年 | 4篇 |
1998年 | 4篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 2篇 |
排序方式: 共有3549条查询结果,搜索用时 0 毫秒
51.
52.
Aghil Igder Scott Pye Ahmed Hussein Mohammed Al-Antaki Alireza Keshavarz Colin L. Raston Ata Nosrati 《RSC advances》2020,10(25):14761
Polysulfone (PSF) was prepared under high shear in a vortex fluidic device (VFD) operating in confined mode, and its properties compared with that prepared using batch processing. This involved reacting the pre-prepared disodium salt of bisphenol A (BPA) with a 4,4′-dihalodiphenylsulfone under anhydrous conditions. Scanning electron microscopy (SEM) established that in the thin film microfluidic platform, the PSF particles are sheet-like, for short reaction times, and fibrous for long reaction times, in contrast to spherical like particles for the polymer prepared using the conventional batch synthesis. The operating parameters of the VFD (rotational speed of the glass tube, its tilt angle and temperature) were systematically varied for establishing their effect on the molecular weight (Mw), glass transition temperature (Tg) and decomposition temperature, featuring gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA) respectively. The optimal VFD prepared PSF was obtained at 6000 rpm rotational speed, 45° tilt angle and 160 °C, for 1 h of processing with Mw ∼10 000 g mol−1, Tg ∼158 °C and decomposition temperature ∼530 °C, which is comparable to the conventionally prepared PSF.Polysulfone (PSF) was prepared under high shear in a vortex fluidic device (VFD) operating in confined mode. This involved reacting the pre-prepared disodium salt of bisphenol A (BPA) with a 4,4′-dihalodiphenylsulfone under anhydrous conditions. 相似文献
53.
Nosocomial infections are one of the major health problems that increase mortality. Pseudomonas aeruginosa is one of the important causes of nosocomial infections. This bacterium has a gene called the lasB gene, the product of which is a zinc-dependent metalloprotease. This gene plays a central role in the pathogenesis of Pseudomonas spp. This pathogen is highly toxic and destroys tissues and also has a moderating effect on the immune system; on the other hand, it initiates the intracellular pathway of biofilm growth. Although there are methods such as molecular methods for identifying the lasB gene, due to the high cost and the need for specialized personnel, it is necessary to replace them with an appropriate method. In this study, a gold nanoparticle-based DNA diagnostic sensor sensitive to the aggregation states of gold nanoparticles was used to identify amplified and non-amplified lasB genes. The results of the experiment were evaluated both visually and spectrally. The minimum detection value of this method was 10 ng of the amplified lasB gene and 50 ng of the non-amplified lasB gene. This method is very fast, simple, easy and low cost.In this study, a gold nanoparticle-based DNA diagnostic sensor that is sensitive to the aggregation states of gold nanoparticles was used to identify the amplified and non-amplified lasB gene. 相似文献
54.
55.
Rahim Mohammadi Keyvan Amini Mehdi Abdollahi-Pirbazari Alireza Yousefi 《Neurologia medico-chirurgica》2013,53(12):839-846
Local effect of acetyl salicylic acid (ASA) on peripheral nerve regeneration was studied using a rat sciatic nerve transection model. Forty-five male healthy White Wistar rats were divided into three experimental groups (n = 15), randomly: Sham-operation (SHAM), control (SIL), and ASA-treated (SIL/ASA) groups. In SHAM group after anesthesia left sciatic nerve was exposed through a gluteal muscle incision and after homeostasis the muscle was sutured. In SIL group the left sciatic nerve was exposed the same way and transected proximal to tibio-peroneal bifurcation leaving a 10-mm gap. Proximal and distal stumps were each inserted into a silicone tube and filled with 10 μl phosphate buffered solution. In SIL/ASA group defect was bridged using a silicone tube filled with 10 μl acetyl salisylic acid (0.1 mg/ml). Each group was subdivided into three subgroups of five animals each and were studied 4, 8, and 12 weeks after surgery. Data were analyzed statistically by factorial analysis of variance (ANOVA) and the Bonferroni test for pair-wise comparisons. Functional study confirmed faster and better recovery of regenerated axons in SIL/ASA than in SIL group (p < 0.05). Gastrocnemius muscle mass in SIL/ASA was significantly more than in SIL group. Morphometric indices of regenerated fibers showed that the number and diameter of the myelinated fibers in SIL/ASA were significantly higher than in control group. In immuohistochemistry, location of reactions to S-100 in SIL/ASA was clearly more positive than in SIL group. Response to local treatment of ASA demonstrates that it influences and improves functional recovery of peripheral nerve regeneration. 相似文献
56.
57.
58.
59.
Shimada Y Sadr A Nazari A Nakagawa H Otsuki M Tagami J Sumi Y 《Dental materials journal》2012,31(3):409-417
Internal adaptation of restorations to the cavity wall is one of the important topics in clinical dentistry. The purpose of this study was to investigate the possibility to utilize the non-invasive tomographic imaging system for teaching the importance of cavity adaptation at dental school pre-clinical training. Swept-source optical coherence tomography (SS-OCT) was used for detection of marginal and internal defects in the composite resin restorations as an educational device. Class 1 and Class 2 composite restorations to melamine resin molar tooth were assigned to the students and prepared during the skill test, and SS-OCT imaging was performed to evaluate students' works. SS-OCT could detect the internal gaps and voids within the restorations in tomography images synthesized based on the backscatter signal from within the restoration. It is suggested that the SS-OCT is promising diagnostic modality, as well as educational imaging device for the detection of internal gaps in adhesive restorations. 相似文献
60.
This study was aimed to determine the effectiveness of grinding and pre-etching in promotion of adhesion to human intact enamel using the self-etch adhesive (SEA) Adper Easy Bond (3M ESPE). Etch-and-rinse adhesive Adper Single Bond (3M ESPE) served as control. Composite cylinders (AP-X Kuraray) were built and after 24 h micro-shear bond strengths (MSBS) were measured. Bonding interfaces were evaluated under scanning electron microscope (SEM). For evaluation of average roughness (Ra) and morphological analysis, treated enamel surfaces were observed under SEM and confocal laser scanning microscope (CLSM) with 3D surface profiling. Highest bond strengths were obtained by pre-etching and grinding showed a less significant role. Phosphoric acid (PA) etching compare to grinding created significantly rougher surface (Ra: 0.72 and 0.43 μm respectively). Therefore, this study recommends pre-etching the intact enamel prior to application of the adhesive instead of grinding. 相似文献