全文获取类型
收费全文 | 10202篇 |
免费 | 757篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 77篇 |
儿科学 | 293篇 |
妇产科学 | 293篇 |
基础医学 | 1375篇 |
口腔科学 | 233篇 |
临床医学 | 1274篇 |
内科学 | 2031篇 |
皮肤病学 | 259篇 |
神经病学 | 1076篇 |
特种医学 | 184篇 |
外科学 | 893篇 |
综合类 | 64篇 |
一般理论 | 16篇 |
预防医学 | 1302篇 |
眼科学 | 180篇 |
药学 | 680篇 |
中国医学 | 32篇 |
肿瘤学 | 733篇 |
出版年
2023年 | 120篇 |
2022年 | 219篇 |
2021年 | 462篇 |
2020年 | 263篇 |
2019年 | 359篇 |
2018年 | 375篇 |
2017年 | 273篇 |
2016年 | 314篇 |
2015年 | 316篇 |
2014年 | 393篇 |
2013年 | 579篇 |
2012年 | 829篇 |
2011年 | 821篇 |
2010年 | 472篇 |
2009年 | 372篇 |
2008年 | 632篇 |
2007年 | 620篇 |
2006年 | 569篇 |
2005年 | 540篇 |
2004年 | 455篇 |
2003年 | 438篇 |
2002年 | 389篇 |
2001年 | 42篇 |
2000年 | 34篇 |
1999年 | 39篇 |
1998年 | 68篇 |
1997年 | 68篇 |
1996年 | 60篇 |
1995年 | 51篇 |
1994年 | 40篇 |
1993年 | 45篇 |
1992年 | 32篇 |
1991年 | 31篇 |
1990年 | 26篇 |
1989年 | 24篇 |
1988年 | 27篇 |
1987年 | 28篇 |
1986年 | 25篇 |
1985年 | 26篇 |
1984年 | 33篇 |
1983年 | 39篇 |
1982年 | 35篇 |
1981年 | 35篇 |
1980年 | 41篇 |
1979年 | 13篇 |
1978年 | 17篇 |
1977年 | 18篇 |
1975年 | 14篇 |
1973年 | 15篇 |
1970年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
41.
Ioana Maris Sabine Dölle-Bierke Jean-Marie Renaudin Lars Lange Alice Koehli Thomas Spindler Jonathan Hourihane Kathrin Scherer Katja Nemat C. Kemen Irena Neustädter Christian Vogelberg Thomas Reese Ismail Yildiz Zsolt Szepfalusi Hagen Ott Helen Straube Nikolaos G. Papadopoulos Susanne Hämmerling Ute Staden Michael Polz Tihomir Mustakov Ewa Cichocka-Jarosz Renata Cocco Alessandro Giovanni Fiocchi Montserrat Fernandez-Rivas Margitta Worm Network for Online Registration of Anaphylaxis 《Allergy》2021,76(5):1517-1527
Background
Peanut allergy has a rising prevalence in high-income countries, affecting 0.5%–1.4% of children. This study aimed to better understand peanut anaphylaxis in comparison to anaphylaxis to other food triggers in European children and adolescents.Methods
Data was sourced from the European Anaphylaxis Registry via an online questionnaire, after in-depth review of food-induced anaphylaxis cases in a tertiary paediatric allergy centre.Results
3514 cases of food anaphylaxis were reported between July 2007 - March 2018, 56% in patients younger than 18 years. Peanut anaphylaxis was recorded in 459 children and adolescents (85% of all peanut anaphylaxis cases). Previous reactions (42% vs. 38%; p = .001), asthma comorbidity (47% vs. 35%; p < .001), relevant cofactors (29% vs. 22%; p = .004) and biphasic reactions (10% vs. 4%; p = .001) were more commonly reported in peanut anaphylaxis. Most cases were labelled as severe anaphylaxis (Ring&Messmer grade III 65% vs. 56% and grade IV 1.1% vs. 0.9%; p = .001). Self-administration of intramuscular adrenaline was low (17% vs. 15%), professional adrenaline administration was higher in non-peanut food anaphylaxis (34% vs. 26%; p = .003). Hospitalization was higher for peanut anaphylaxis (67% vs. 54%; p = .004).Conclusions
The European Anaphylaxis Registry data confirmed peanut as one of the major causes of severe, potentially life-threatening allergic reactions in European children, with some characteristic features e.g., presence of asthma comorbidity and increased rate of biphasic reactions. Usage of intramuscular adrenaline as first-line treatment is low and needs to be improved. The Registry, designed as the largest database on anaphylaxis, allows continuous assessment of this condition.42.
Lymphocyte Transformation in Syphilis: an In Vitro Correlate of Immune Suppression In Vivo? 总被引:6,自引:10,他引:6 下载免费PDF全文
Daniel M. Musher Ronald F. Schell Ronald H. Jones Alice M. Jones 《Infection and immunity》1975,11(6):1261-1264
Suppression of cellular immunity during primary and secondary infection may explain, in part, the unusual clinical evolution of syphilis. We have previously shown that lymphocytes from normal subjects undergo blastic transformation when exposed in vitro to Treponema refringens. This response was suppressed in patients with syphilis. the suppression being unrelated to serum factors. In the present paper we studied lymphocyte response in vitro to T. refringens, T. reiter, and T. pallidum as well as to monilia and trychophytins. The response to these antigens was suppressed in patients with syphilis although the response to phytohemagglutinin. pokeweed mitogen, and streptolysin was normal. These data support the hypothesis that human infection with T. pallidum is followed by a complex interaction between cellular and humoral immunity, the former being suppressed in primary and secondary stages. 相似文献
43.
Burzynski GM Nolte IM Osinga J Ceccherini I Twigt B Maas S Brooks A Verheij J Plaza Menacho I Buys CH Hofstra RM 《European journal of human genetics : EJHG》2004,12(8):604-612
Hirschsprung disease (HSCR), a congenital disorder characterized by intestinal obstruction due to absence of enteric ganglia along variable lengths of the intestinal tract, occurs both in familial and sporadic cases. RET mutations have been found in approximately 50% of the families, but explains only a minority of sporadic cases. This study aims at investigating a possible role of RET in sporadic HSCR patients. Haplotypes of 13 DNA markers, within and flanking RET, have been determined for 117 sporadic HSCR patients and their parents. Strong association was observed for six markers in the 5' region of RET. The largest distortions in allele transmission were found at the same markers. One single haplotype composed of these six markers was present in 55.6% of patients versus 16.2% of controls. Odds ratios (ORs) revealed a highly increased risk of homozygotes for this haplotype to develop HSCR (OR>20). These results allowed us to conclude that RET plays a crucial role in HSCR even when no RET mutations are found. An unknown functional disease variant(s) with a dosage-dependent effect in HSCR is likely located between the promoter region and exon 2 of RET. 相似文献
44.
Silva ML Ornellas de Souza MH Ribeiro RC Land MG Boulhosa de Azevedo AM Vasconcelos F Otero L Vasconcelos Z Bouzas LF Abdelhay E 《Cancer Genetics and Cytogenetics》2002,137(2):85-90
We report the cytogenetic analysis of newly diagnosed Brazilian children with acute lymphocytic leukemia (ALL). We investigated 100 ALL cases from four different institutions in Rio de Janeiro. The frequency of chromosomal abnormalities was 92.3%. The karyotype profile and recurrent abnormalities found in this study do not differ essentially from those described by other groups. Although the Brazilian population is usually the product of different ethnic groups, our results show that the frequency of each recurrent abnormality is similar to that found in populations without our degree of diverse ethnic composition. Hence, our results suggest that childhood ALL in Brazil has the same biological features as that in developed countries, supporting the use of similar treatment protocols. We can therefore expect to reach the same survival rates in the coming years, depending possibly on the efficacy of the support therapy and extent of social assistance. 相似文献
45.
46.
Andrulis IL Anton-Culver H Beck J Bove B Boyd J Buys S Godwin AK Hopper JL Li F Neuhausen SL Ozcelik H Peel D Santella RM Southey MC van Orsouw NJ Venter DJ Vijg J Whittemore AS;Cooperative Family Registry for Breast Cancer studies 《Human mutation》2002,20(1):65-73
A number of methods are used for mutational analysis of BRCA1, a large multi-exon gene. A comparison was made of five methods to detect mutations generating premature stop codons that are predicted to result in synthesis of a truncated protein in BRCA1. These included four DNA-based methods: two-dimensional gene scanning (TDGS), denaturing high performance liquid chromatography (DHPLC), enzymatic mutation detection (EMD), and single strand conformation polymorphism analysis (SSCP) and an RNA/DNA-based protein truncation test (PTT) with and without complementary 5' sequencing. DNA and RNA samples isolated from 21 coded lymphoblastoid cell line samples were tested. These specimens had previously been analyzed by direct automated DNA sequencing, considered to be the optimum method for mutation detection. The set of 21 cell lines included 14 samples with 13 unique frameshift or nonsense mutations, three samples with two unique splice site mutations, and four samples without deleterious mutations. The present study focused on the detection of protein-truncating mutations, those that have been reported most often to be disease-causing alterations that segregate with cancer in families. PTT with complementary 5' sequencing correctly identified all 15 deleterious mutations. Not surprisingly, the DNA-based techniques did not detect a deletion of exon 22. EMD and DHPLC identified all of the mutations with the exception of the exon 22 deletion. Two mutations were initially missed by TDGS, but could be detected after slight changes in the test design, and five truncating mutations were missed by SSCP. It will continue to be important to use complementary methods for mutational analysis. 相似文献
47.
48.
Rabon-Stith KM Hagberg JM Phares DA Kostek MC Delmonico MJ Roth SM Ferrell RE Conway JM Ryan AS Hurley BF 《Experimental physiology》2005,90(4):653-661
To determine the influence of the vitamin D receptor (VDR) gene FokI and BsmI genotype on bone mineral density response to two exercise training modalities, 206 healthy men and women (50-81 years old) were studied before and after approximately 5-6 months of either aerobic exercise training (AT) or strength training (ST). A totla of 123 subjects completed AT (51 men, 72 women) and 83 subjects completed ST (40 men, 43 women). DNA was extracted from blood samples of all subjects and genotyping was performed at the VDR FokI and BsmI locus to determine its association to training response. Total body, greater trochanter and femoral neck bone mineral density (BMD) were measured before and after both training programmes using dual-energy X-ray absorptiometry. VDR BsmI genotype was not significantly related to BMD at baseline or after ST or AT. However, VDR FokI genotype was significantly related to ST- but not AT-induced changes in femoral neck BMD (P < 0.05). The heterozygotes (Ff) in the ST group approached a significantly greater increase in femoral neck BMD (P = 0.058) compared to f homozygotes. There were no significant genotype relationships in the AT group. These data indicate that VDR FokI genotype may influence femoral neck BMD response to ST, but not AT. 相似文献
49.
黎程正 《中国心理卫生杂志》1994,8(5):213-216
采用“家长生活调查问卷”对广州市就读专收HAA阳性幼儿园的父母、未有就读任何幼儿园HAA阳性儿童的父母、以及就读普通幼儿园健康儿童父母进行了调查,结果发现HAA阳性儿童的父母由于承受较大的心理压力而出现更多的心理问题、这种压力影响到父母的身心健康。资料为社会保健提供了依据。 相似文献