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Goland S Czer LS Siegel RJ Tabak S Jordan S Luthringer D Mirocha J Coleman B Kass RM Trento A 《The Canadian journal of cardiology》2008,24(7):571-574
BACKGROUND:
Although an autoimmune mechanism has been postulated for myocarditis and acute-onset inflammatory dilated cardiomyopathy (DCM), immunomodulatory treatment strategies are still under investigation.METHODS AND RESULTS:
The clinical data of six patients with acute inflammatory DCM referred for evaluation for possible heart transplantation were reviewed. All patients were admitted with acute congestive heart failure and severely impaired left ventricular (LV) function and were treated with high-dose (2 g/kg) intravenous immunoglobulin (IVIG). The diagnosis of acute inflammatory DCM was based on recent onset of congestive heart failure (New York Heart Association functional class III or IV) with severely depressed LV ejection fraction ([LVEF] 30% or lower) occurring shortly after viral-like illness. All patients had inflammation on endomyocardial biopsy or elevated cardiac enzymes, as well as a normal coronary angiogram. All patients were in New York Heart Association class I or II at the time of hospital discharge. The mean LVEF improved from 21.7±7.5% at baseline to 50.3±8.6% at discharge (P=0.005). Four patients had complete recovery (LVEF 50% or higher) and two patients had partial LV recovery. Patients were followed for a median 13.2 months (range two to 24 months) and had a mean LVEF of 53±6% (P not significant versus LVEF at discharge).CONCLUSIONS:
Therapy with intravenous high-dose IVIG may be a potentially useful treatment in selected patients if given early in the course of acute fulminant inflammatory DCM. A randomized, prospective trial is warranted to prove the real benefit of IVIG in this patient population. 相似文献84.
Cibele Almeida Santos Renata Calhes Franco de Moura Roberta Delasta Lazzari Arislander Jonathan Lopes Dumont Luiz Alfredo Ferreira Braun Claudia Santos Oliveira 《Journal of Physical Therapy Science》2015,27(5):1617-1620
[Purpose] The aim of the present study was to perform a systematic review of the
literature on the scales and methods most often used for the evaluation of upper limb
function in individuals with cerebral palsy. [Materials and Methods] Searches were
conducted in the Medline, PEDro, Lilacs, Scielo, and PubMed databases. The following
inclusion criteria were used for the selection of articles: randomized controlled study,
evaluation of upper limb function in individuals with cerebral palsy, and publication
between 2006 and 2014. The methodological quality of the articles was evaluated using the
PEDro evidence scale. [Results] Five articles met the inclusion criteria and achieved 6
points or higher on the PEDro scale of methodological quality. [Conclusion] The studies
analyzed used different evaluation scales, but no consensus has been reached thus far on
which scale is the most appropriate. Thus, further studies are needed to establish an
adequate method for the evaluation of upper limb function in individuals with cerebral
palsy.Key words: Cerebral palsy, Scale function, Upper limbs 相似文献
85.
Does offering human immunodeficiency virus testing at the time of blood donation reduce transfusion transmission risk and increase disclosure counseling? Results of a randomized controlled trial,São Paulo,Brazil 下载免费PDF全文
86.
Effect of Active Music Therapy and Individualized Listening to Music on Dementia: A Multicenter Randomized Controlled Trial 下载免费PDF全文
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Stefano Scarperi Giovanni Pontrelli Colette Campana Martin Steinkasserer Alfredo Ercoli Luca Minelli Valentino Bergamini Marcello Ceccaroni 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2015,19(4)
Background and Objectives:
Symptomatic uterine adenomyosis, unresponsive to medical therapy, is a challenging condition for patients who desire to preserve their uterus. This study was an evaluation of the feasibility and efficacy of laparoscopic radiofrequency thermal ablation of symptomatic nodular uterine adenomyosis.Methods:
Fifteen women with symptomatic nodular adenomyosis, who had no plans for pregnancy but declined hysterectomy, underwent radiofrequency thermal ablation. Ultrasonography was performed at baseline and at postoperative follow-ups at 3, 6, 9, and 12 months. The impact of uterine adenomyosis–related symptoms was assessed according to the visual analog scale.Results:
The median number of nodular lesions treated per patient was 1 (range, 1–2). The median baseline volume of the adenomyosis area was 60 cm3 (range, 18–128). The median reduction in volume was 32, 49.4, 59.6, and 65.4% at 3, 6, 9, and 12 months, respectively. A significant progressive improvement in the symptoms score was observed at the 4 follow-ups.Conclusion:
In this study, laparoscopic radiofrequency thermal ablation reduced uterine adenomyosis–related symptoms and volume, with significant relief of symptoms. 相似文献88.
89.
Enzo Ierardi Claudia Sorrentino Mariabeatrice Principi Floriana Giorgio Giuseppe Losurdo Alfredo Di Leo 《肝胆外科与营养》2015,4(4):289-292
Intestinal microbiota is a “dynamic organ” influencing host metabolism, nutrition, physiology and immune system. Among its several interactions, the role of a phosphatidylcholine metabolite derived by gut flora activity, i.e., trimethylamine-N-oxide (TMAO), allows perceiving a novel insight in the cardiovascular risk scenario, being a strong predictor of this condition. Based on current reports, including the paper of Tang et al., we describe here: the possible role of intestinal microbiota in cardiovascular risk as well as potential interventions to reduce gut flora TMAO production by diet, probiotics and antibiotics. Finally, we highlight the possibility of evaluating, monitoring and modulating TMAO in order to use its serum levels as a marker of cardiovascular risk in the next future, when the need of controlled studies on large series will be satisfied. 相似文献
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