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91.
Stuart Chalew Ricardo Gomez Alfonso Vargas Jodi Kamps Brittney Jurgen Richard Scribner James Hempe 《Journal of diabetes and its complications》2018,32(12):1085-1090
Introduction
Black youth with type 1 diabetes (T1D) have higher HbA1c than whites. To understand HbA1c differences, we examined the relationship of psycho-social factors and glucose testing with HbA1c.Methods
Glucose tests per day (BGs/d) and mean blood glucose (MBG) were calculated from meter data of youth self-identified as black (n?=?33) or white (n?=?53) with T1D. HbA1c, family income, insurance status, concentrated disadvantage (CDI), psychological depression (DSC), mother educational attainment (MEA), and insulin delivery method (IDM) data was were analyzed.Results
Black patients had significantly higher HbA1c, MBG and disadvantage measures compared to whites. BGs/d correlated with HbA1c, MBG, age and CDI. Race (p?<?0.0158), age (p?<?0.0001) and IDM (p?<?0.0036) accounted for 50% of the variability (R2?=?0.5, p?<?0.0001) in BGs/d. Regardless of age, black patients had lower BGs/d than whites. MBG (p?<?0.0001) and BGs/d (p?<?0.0001) accounted for 61% of the variance in HbA1c (p?<?0.0001).Conclusions
BGs/d is easily assessed and closely associated with HbA1c racial disparity. BGs/d is intricately linked with greater social disadvantage. Innovative management approaches are needed to overcome obstacles to optimal outcomes. 相似文献92.
Amanda Hidalgo‐Peréz ángela Fernández‐García Ibai López‐de‐Uralde‐Villanueva Alfonso Gil‐Martínez Alba Paris‐Alemany Josué Fernández‐Carnero Roy La Touche 《International Journal of Sports Physical Therapy》2015,10(6):877-892
Background
Motor control therapeutic exercise (MCTE) for the neck is a motor relearning program that emphasizes the coordination and contraction of specific neck flexor, extensor, and shoulder girdle muscles. Because motor imagery (MI) improves sensorimotor function and it improves several motor aspects, such as motor learning, neuromotor control, and acquisition of motor skills, the authors hypothesized that a combination of MCTE and MI would improve the sensorimotor function of the cervical spine more effectively than a MCTE program alone.Purpose
The purpose of this study was to investigate the influence of MI combined with a MCTE program on sensorimotor function of the craniocervical region in asymptomatic subjects.Study Design
This study was a single‐blinded randomized controlled trial.Methods
Forty asymptomatic subjects were assigned to a MCTE group or a MCTE+MI group. Both groups received the same MCTE program for the cervical region (60 minutes), but the MCTE+MI group received an additional intervention based on MI (15 minutes). The primary outcomes assessed were craniocervical neuromotor control (activation pressure value and highest pressure value), cervical kinesthetic sense (joint position error [JPE]), and the subjective perception of fatigue after effort.Results
Intra‐group significant differences were obtained between pre‐ and post interventions for all evaluated variables (p<0.01) in the MCTE+MI and MCTE groups, except for craniocervical neuromotor control and the subjective perception of fatigue after effort in the MCTE group. In the MCTE+MI group a large effect size was found for craniocervical neuromotor control (d between ‐0.94 and ‐1.41), cervical kinesthetic sense (d between 0.97 and 2.14), neck flexor muscle endurance test (d = ‐1.50), and subjective perception of fatigue after effort (d = 0.79). There were significant inter‐group differences for the highest pressure value, joint position error (JPE) extension, JPE left rotation, and subjective perception of fatigue after effort.Conclusion
The combined MI and MCTE intervention produced statistically significant changes in sensorimotor function variables of the craniocervical region (highest pressure value, JPE extension and JPE left rotation) and the perception of subjective fatigue compared to MCTE alone. Both groups showed statistically significant changes in all variables measured, except for craniocervical neuromotor control and the subjective perception of fatigue after effort in the MCTE groupLevel of Evidence
1b 相似文献93.
David Vivas Inmaculada Roldán Raquel Ferrandis Francisco Marín Vanessa Roldán Antonio Tello-Montoliu Juan Miguel Ruiz-Nodar Juan José Gómez-Doblas Alfonso Martín Juan Vicente Llau María José Ramos-Gallo Rafael Muñoz Juan Ignacio Arcelus Francisco Leyva Fernando Alberca Raquel Oliva Ana María Gómez Carmen Montero Andrés Íñiguez 《Revista espa?ola de cardiología》2018,71(7):553-564
During the last few years, the number of patients receiving anticoagulant and antiplatelet therapy has increased worldwide. Since this is a chronic treatment, patients receiving it can be expected to need some kind of surgery or intervention during their lifetime that may require treatment discontinuation. The decision to withdraw antithrombotic therapy depends on the patient's thrombotic risk versus hemorrhagic risk. Assessment of both factors will show the precise management of anticoagulant and antiplatelet therapy in these scenarios. The aim of this consensus document, coordinated by the Cardiovascular Thrombosis Working Group of the Spanish Society of Cardiology, and endorsed by most of the Spanish scientific societies of clinical specialities that may play a role in the patient-health care process during the perioperative or periprocedural period, is to recommend some simple and practical guidelines with a view to homogenizing daily clinical practice.Full English text available from: www.revespcardiol.org/en 相似文献
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97.
Delia Blanco Esther Perez-Herran Mónica Cacho Lluís Ballell Julia Castro Rubén González del Río José Luis Lavandera Modesto J. Remui?án Cindy Richards Joaquin Rullas María Jesús Vázquez-Mu?iz Ermias Woldu María Cleofé Zapatero-González I?igo Angulo-Barturen Alfonso Mendoza David Barros 《Antimicrobial agents and chemotherapy》2015,59(4):1868-1875
One way to speed up the TB drug discovery process is to search for antitubercular activity among compound series that already possess some of the key properties needed in anti-infective drug discovery, such as whole-cell activity and oral absorption. Here, we present MGIs, a new series of Mycobacterium tuberculosis gyrase inhibitors, which stem from the long-term efforts GSK has dedicated to the discovery and development of novel bacterial topoisomerase inhibitors (NBTIs). The compounds identified were found to be devoid of fluoroquinolone (FQ) cross-resistance and seem to operate through a mechanism similar to that of the previously described NBTI GSK antibacterial drug candidate. The remarkable in vitro and in vivo antitubercular profiles showed by the hits has prompted us to further advance the MGI project to full lead optimization. 相似文献
98.
Michael C. Verre Jesus Peinado Eddy R. Segura Jesse Clark Pedro Gonzales Carlos Benites Robinson Cabello Jorge Sanchez Javier R. Lama 《AIDS and behavior》2014,18(10):2030-2039
The association of socialization patterns with unprotected anal intercourse (UAI) and HIV/STI prevalence remains underexplored in men who have sex with men (MSM) and transgender women (TW) in developing country settings. We evaluated the correlation of UAI, HIV, and syphilis with MSM/TW venue attendance and social network size among high-risk MSM and TW in Peru according to self-reported sexual identity. Frequency of venue attendance and MSM/TW social network size were lowest among heterosexual MSM and highest among TW respondents. Attendance (frequent or occasional) at MSM/TW venues was associated with increased odds of insertive UAI among heterosexual participants. Frequent venue attendance was associated with increased odds of receptive UAI among gay/homosexual, bisexual, and TW participants. Further investigation of the differing socialization patterns and associations with HIV/STI transmission within subgroups of Peruvian MSM and TW will enable more effective prevention interventions for these populations. 相似文献
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Voriconazole as a first-line treatment against potentially pathogenic Acanthamoeba strains from Peru
Alfonso Martín Cabello-Vílchez Carmen M. Martín-Navarro Atteneri López-Arencibia María Reyes-Batlle Ines Sifaoui Basilio Valladares José E. Piñero Jacob Lorenzo-Morales 《Parasitology research》2014,113(2):755-759
Pathogenic strains of Acanthamoeba genus are the causative agents of fatal granulomatous amoebic encephalitis and a serious sight-threatening infection of the eye known as Acanthamoeba keratitis. In a previous study, Acanthamoeba strains were isolated from nasal swabs collected from healthy individuals in Peru. In the present study, the pathogenic potential of the isolated strains was established based on temperature and osmotolerance assays as well as the secretion rate of extracellular proteases. Based on these experiments, four strains that showed the highest pathogenic potential were selected for sensitivity assays against two molecules (voriconazole and chlorhexidine) which are currently used for the treatment of Acanthamoeba infections. After performing sensitivity and activity assays, it was found that both drugs were active against the tested strains. However, voriconazole showed higher activity against the studied strains compared to chlorhexidine. Therefore, voriconazole should be established as a first-line treatment against Acanthamoeba infections at least in the studied region of Peru. 相似文献